Tag: M.W=150-200

I found the field of Chemistry very interesting. Saw the article A 4-OTBS benzyl-based protective group for carboxylic acids published in 2019.0. Recommanded Product: 4-Nitrobenzoic acid, Reprint Addresses Xie, HX (corresponding author), East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Reported herein is a novel 4-OTBS benzyl-based protective group for carboxylic acids. This protective group can be removed in the presence of TBAF or TFA with high efficiency, which makes it compatible with base-sensitive or acid-sensitive substrates. With this protective group, a near-infrared fluorogenic probe for the detection of gamma-glutamyltranspeptidase activities was readily prepared. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Fang, ZJ; Li, YY; Xie, HX or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Helman, G; Patlewicz, G; Shah, I in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Helman, G.] ORISE, Oak Ridge, TN USA; [Helman, G.; Patlewicz, G.; Shah, I] US Environm Protect Agcy, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC USA in 2019.0, Cited 35.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Computational approaches have recently gained popularity in the field of read-across to automatically fill data-gaps for untested chemicals. Previously, we developed the generalized read-across (GenRA) tool, which utilizes in vitro bioactivity data in conjunction with chemical descriptor information to derive local validity domains to predict hazards observed in in vivo toxicity studies. Here, we modified GenRA to quantitatively predict point of departure (POD) values obtained from US EPA’s Toxicity Reference Database (ToxRefDB) version 2.0. To evaluate GenRA predictions, we first aggregated oral Lowest Observed Adverse Effect Levels (LOAEL) for 1,014 chemicals by systemic, developmental, reproductive, and cholinesterase effects. The mean LOAEL values for each chemical were converted to log molar equivalents. Applying GenRA to all chemicals with a minimum Jaccard similarity threshold of 0.05 for Morgan fingerprints and a maximum of 10 nearest neighbors predicted systemic, developmental, reproductive, and cholinesterase inhibition min aggregated LOAEL values with R-2 values of 0.23, 0.22, 0.14, and 0.43, respectively. However, when evaluating GenRA locally to clusters of structurally-similar chemicals (containing 2 to 362 chemicals), average R-2 values for systemic, developmental, reproductive, and cholinesterase LOAEL predictions improved to 0.73, 0.66, 0.60 and 0.79, respectively. Our findings highlight the complexity of the chemical-toxicity landscape and the importance of identifying local domains where GenRA can be used most effectively for predicting PODs.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Helman, G; Patlewicz, G; Shah, I or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2019.0 CHEMCATCHEM published article about CHEMOSELECTIVE HYDROGENATION; PD NANOPARTICLES; NITRO-COMPOUNDS; REDUCTION; PERFORMANCE; NITROAROMATICS; EXPLORATION; INTERFACES; HYDRAZINE; COMPOSITE in [Tian, Haimeng; Li, Yunong; Wang, Yiming; Liu, Lei; Hu, Ze-Nan; Li, Jifan; Guo, Rongxiu; Liu, Zhibo; Sun, Hong-bin] Northeastern Univ, Dept Chem, Shenyang 110819, Liaoning, Peoples R China; [Zhou, Junjie] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China; [Ai, Yongjian; Liang, Qionglin] Tsinghua Univ, Ctr Synthet & Syst Biol, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem,Minist Educ, Beijing 100084, Peoples R China in 2019.0, Cited 55.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Modifying the surface of metal catalyst is a crucial subject for improving the heterogeneous metal catalysts. It is still a great challenge to understand the structure-activity relationship (SAR) between the surface supporting groups and the metal particles. Herein, Rh NPs supported on the magnetic silica sphere with various functional groups (-NH2, -SH, -SO3H, -N=CH2, -Cl, -NHCOCH3 and -NHCH2Ph) have been prepared for catalytic hydrogenation of nitroarenes under atmospheric pressure at room temperature. We discover that the chemical state of Rh NPs depends on the supporting groups significantly. The electron-donating functionalities can effectively elevate the Rh-0/Rh3+ ratio, which increase the catalytic performance both in conversion and selectivity. The amino group decorated catalyst has such a good selectivity that no dechlorination reaction is observable in the hydrogenation of 2-chloro-3-nitropyridine. What’s more, by introducing magnetic Fe3O4 nuclei and mesoporous silica encapsulating layer, the catalyst can be recovered conveniently by an external magnet, and can be reused 10 cycles without any loss of activity.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Tian, HM; Zhou, JJ; Li, YN; Wang, YM; Liu, L; Ai, YJ; Hu, ZN; Li, JF; Guo, RX; Liu, ZB; Sun, HB; Liang, QL or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q in [Wang, Dan; Lu, Bing; Song, Yan-Ling; Sun, Hong-Mei; Shen, Qi] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China published Fe(III)-catalyzed oxidative coupling of alkylnitriles with aromatic carboxylic acids: Facile access to cyanomethyl esters in 2019, Cited 78. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The first oxidative coupling of alkylnitriles with aromatic carboxylic acids using di-tert-butyl peroxide (DTBP) as oxidant was achieved under the catalysis of ionic Fe(III) complexes bearing an imidazolinium cation. This protocol features nontoxic iron catalysis, direct alpha-C(sp(3))-H bond oxidative esterification of alkylnitriles, non-prefunctionalized starting materials, and a broad substrate scope with outstanding steric hindrance tolerance, providing a novel, straightforward, and green approach toward cyanomethyl ester synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Rhodium-catalysed synthesis of fused pyrimidine derivatives employing N-sulfonyl-1,2,3-triazoles as a 1-aza-[4C] synthon WOS:000474321900010 published article about DIELS-ALDER REACTIONS; ALPHA,BETA-UNSATURATED IMINES; TANDEM REACTION; 1,2,3-TRIAZOLES; TRANSANNULATION; CYCLOADDITION; 2H-AZIRINES; ANNULATION; ALKYNES; 1-SULFONYL-1,2,3-TRIAZOLES in [Xu, Ze-Feng; An, Yuehui; Chen, Yidian; Duan, Shengguo] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Peoples R China; [Xu, Ze-Feng] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019, Cited 59. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A new synthetic application of N-sulfonyl-1,2,3-triazoles acting as a 1-aza-[4C] synthon via the 1,2-shift reaction of an alpha-imine rhodium carbene was developed for the synthesis of fused pyrimidine derivatives. The high reactivity of the strained three-membered 2H-azirine ring facilitated the unusual cyclization of electron-deficient dienes with electron-deficient dienophiles. The compatibility was good with common functionalities tolerated. Excellent chemoselectivity was observed, and no reactions occurred between the rhodium carbene and 2H-azirine. The products could be converted into seven-membered multi-functionalized 1H-1,4-diazepine derivatives, illustrating the potential application of the protocol in medium-sized N-heterocycle synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, ZF; An, YH; Chen, YD; Duan, SG or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J MED CHEM published article about MULTIDRUG-RESISTANT; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; ANTITUBERCULOSIS ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; TUBERCULOSIS; THIADIAZOLES; CYTOTOXICITY; BEDAQUILINE in [Patel, Harun; Jadhav, Harsha; Ansari, Iqrar; Pawara, Rahul; Surana, Sanjay] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur, India in 2019, Cited 33. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

In the present study, a series of substituted 1,3,4-thiadiazole derivatives 4(a-o), 5(a-m) and 6(a-j) were synthesized and characterized by IR, H-1 NMR, C-13 NMR and mass spectroscopic technique. The synthesized compounds were evaluated for their in vitro anti-mycobacterial activity against the Mycobacterium tuberculosis H37Rv and resistance MDR-TB strain. Among the compounds tested N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)furan-2-carboxamide (4h) showed significant inhibitory activity with MIC of 9.87 mu M (H37Rv strain) and 9.87 mu M (MDR-TB strain) compared to isoniazide (MIC of 3.64 mu M (H37Rv) and >200 mu M (MDR-TB strain)] and rifampin [MIC of 0.152 mu M (H37Rv) and 128 mu M (MDR-TB strain)]. In addition, these compounds have also been assessed for their cyto-toxicity to a mammalian Vero cell line using the MTT assay. The result shows that these compounds exhibit anti-tubercular activity at non-cytototoxic concentrations. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Patel, H; Jadhav, H; Ansari, I; Pawara, R; Surana, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Novel Pyrazolo[3,4-d]pyrimidine-Containing Amide Derivatives: Synthesis, Molecular Docking, In Vitro and In Vivo Antidiabetic Activity WOS:000490895800027 published article about BIOLOGICAL EVALUATION; DIABETES-MELLITUS; INHIBITORS; ANTIBACTERIAL; PYRIMIDINE; DIET in [Reddy, Bijivemula N.; Pathak, Madhvesh] Vellore Inst Technol, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Ruddarraju, Radhakrishnam Raju] Factory Plot 79-B&C, Patancheru 502307, Andhra Pradesh, India; [Ruddarraju, Radhakrishnam Raju] Jawaharlal Nehru Technol Univ, Hyderabad 500085, Telangana, India; [Kiran, Gangarapu] Anurag Grp Inst, Dept Pharmaceut Anal & Chem, Sch Pharm, Ghatkesar M, Telangana, India; [Reddy, Anreddy Rama Narsimha] Jyothishmathi Inst Pharmaceut Sci, Dept Pharmacol, Karimnagar 505481, Telangana, India in 2019, Cited 45. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A new series of Pyrazolo[3,4-d]pyrimidine containing amide derivatives (8 a-l) were designed, synthesized, and evaluated for their in vitro alpha-amylase inhibitory activity. The IC50 values of the target compounds ranged from 1.60 +/- 0.48 to 2.04 +/- 1.20 mu M as compared to the standard acarbose 1.73 +/- 0.05 mu M. All the Pyrazolo[3,4-d]pyrimidine amide derivatives displayed good inhibitory activities, while seven analogs (8 d, 8 f, 8 g, 8 h, 8 i, 8 j and 8 k) exhibited more or less equipotent activity with IC50 values 1.77 +/- 2.84, 1.65 +/- 0.45, 1.66 +/- 2.24, 1.73 +/- 0.37, 1.60 +/- 0.48, 1.75 +/- 0.36 and 1.64 +/- 0.03 mu M respectively. Further, the most potent alpha-amylase inhibitors 8 d and 8 k were also screened for their in vivo antidiabetic activity against alloxan induced diabetic rat model at the dose of 25 and 50 mg/kg. Oral administration of these tested compounds significantly reduced the fasting blood glucose levels in dose dependent manner. The hypoglycemic effects of these compounds were more evident at 3 h and 5 h after administration of tested compounds which was similar to the effect displayed by the positive control. In addition, the binding energies calculated from the docking studies with the alpha-amylase enzyme (PDB ID: 1HNY) and biological activities indicate that the compounds containing nitro moiety on the phenyl group contributed significantly towards the antidiabetic activity.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Reddy, BN; Ruddarraju, RR; Kiran, G; Pathak, M; Reddy, ARN or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

He, ZL; Liu, J; Wang, QJ; Zhao, W; Wen, ZP; Chen, J; Manoj, D; Xie, CY; Xi, JB; Yu, JX; Tang, CY; Bai, ZW; Wang, S in [He, Zhaolin; Liu, Jin; Zhao, Wang; Wen, Zhipan; Chen, Jun; Xi, Jiangbo; Yu, Junxia; Bai, Zhengwu] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China; [Wang, Qijun; Manoj, Devaraj; Xie, Chuyi; Wang, Shuai] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Hubei, Peoples R China; [Tang, Chunyan] Guangxi Univ, Sch Comp Elect & Informat, Nanning 530004, Guangxi, Peoples R China published Metal-free carbocatalyst for catalytic hydrogenation of N-containing unsaturated compounds in 2019.0, Cited 53.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Eco-friendly carbocatalyst is extremely desirable in organic catalysis and wastewater treatment. Herein, we reported a one-pot synchronous hydrothermal process to synthesize a highly efficient N doped holey graphene (NHG) carbocatalyst, in which graphene oxide nanosheets are self-assembled, reduced, chemically etched, and simultaneously doped with nitrogen to form a graphene hydrogel in the presence of H2O2 and NH4OH. Benefiting from the good hydrophilicity, unique hierarchical porous structure, large specific surface area (322.1 m(2)g(-1)), and high N content (9.77 at. %), the resultant NHG carbocatalyst exhibits an excellent catalytic performance for the hydrogenation of N-containing unsaturated compounds. In 4-nitrophenol reduction reaction, the NHG carbocatalyst delivers a turnover frequency of 3.32 x 10(-2) min(-1). This catalytic activity is superior to that of the commercial Pd/C (5.0 wt%), other previously reported carbocatalysts, and many noble-metal-based catalysts. Furthermore, the molecular structure analysis combined with density functional theory calculations elucidate metal-free catalytic mechanism of hydrogenation reaction for unsaturated chromophore groups in N-containing organic dyes. (C) 2019 Elsevier Inc. All rights reserved.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact He, ZL; Liu, J; Wang, QJ; Zhao, W; Wen, ZP; Chen, J; Manoj, D; Xie, CY; Xi, JB; Yu, JX; Tang, CY; Bai, ZW; Wang, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation WOS:000471912700036 published article about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China in 2019, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article A Unified Synthetic Approach to Optically Pure Curvularin-Type Metabolites WOS:000471212000062 published article about STEREOSELECTIVE TOTAL-SYNTHESIS; SYNTHASE EXPRESSION; (S)-CURVULARIN; CONSTRUCTION; AETHERAMIDES; MACROLIDES; INHIBITORS in [Allu, Srinivasa Rao; Banne, Sreenivas; Jiang, Jia; Qi, Na; Guo, Jian; He, Yun] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China; [Qi, Na] Chongqing Univ, Coll Bioengn, Biomed & Hlth Engn Lab, Chongqing 401331, Peoples R China in 2019.0, Cited 40.0. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A unified and concise approach to the synthesis of nine curvularin-type metabolites and two analogues has been developed with few steps and high yields. Among them, sumalactones A-D were synthesized for the first time. The key steps in this approach included esterification, Friedel-Crafts acylation, and ring-closing metathesis (or cross metathesis).

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Allu, SR; Banne, S; Jiang, J; Qi, N; Guo, J; He, Y or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem