Tag: M.W=150-200

Bertrand, X; Paquin, JF in [Bertrand, Xavier; Paquin, Jean-Francois] Univ Laval, Dept Chim, PROTEO, CCVC, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada published Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination in 2019.0, Cited 27.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Bertrand, X; Paquin, JF or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. In 2019 MOLECULES published article about STANDARD MOLAR ENTHALPY; STRUCTURE-PROPERTY RELATIONSHIPS; THERMODYNAMIC PROPERTIES; IONIC LIQUIDS; THERMOPHYSICAL PROPERTIES; TEMPERATURE-RANGE; GROUP ADDITIVITY; VAPOR-PRESSURES; THERMAL-ANALYSIS; COMPUTATIONAL THERMOCHEMISTRY in [Naef, Rudolf] Univ Basel, Dept Chem, CH-4003 Basel, Switzerland in 2019, Cited 287. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Naef, R or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH in [Liu, Qingbo; Li, Wei; Asada, Yoshihisa; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan; [Liu, Qingbo] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan; [Huang, Li; Chen, Chin-Ho] Duke Univ, Med Ctr, Dept Surg, Surg Sci, Durham, NC 27710 USA published Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents in 2019, Cited 21. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gnidimacrin derivatives were synthesized and evaluated in assays for HIV replication and latency activation to establish which molecular structures must be maintained and which can tolerate changes that may be needed for better pharmacological properties. The results indicated that hydroxyl substituents at C-5 and C-20 are essential, while derivatives modified at 3-OH with aromatic esters retain anti-HIV replication and latent activation activities. The half-lives of the potent GM derivatives are over 20 h, which implies that they are stable in the plasm even though they contain ester linkages. The established structure activity relationship should be useful in the development of gnidimacrin or structurally related compounds as clinical trial candidates.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. I found the field of Chemistry very interesting. Saw the article Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2 published in 2019.0, Reprint Addresses Audisio, D (corresponding author), Univ Paris Saclay, CEA, DRF, SCBM,JOLIOT, F-91191 Gif Sur Yvette, France.; Cantat, T (corresponding author), Univ Paris Saclay, CNRS, CEA, NIMBE, F-91191 Gif Sur Yvette, France.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [C-14]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early C-14-based ADME studies supporting drug development.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Destro, G; Loreau, O; Marcon, E; Taran, F; Cantat, T; Audisio, D or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 CHEM ENG J published article about PERSONAL CARE PRODUCTS; GRAPHITIC CARBON NITRIDE; WATER TREATMENT PLANTS; ELECTRONIC-STRUCTURE; HYDROGEN EVOLUTION; PHARMACEUTICALS; PERFORMANCE; CHARGE; HETEROJUNCTION; G-C3N4 in [Jiang, Runren; Lu, Guanghua; Yan, Zhenhua; Wu, Donghai; Zhou, Ranran; Bao, Xuhui] Hohai Univ, Coll Environm, Minist Educ, Key Lab Integrated Regulat & Resources Dev Shallo, Nanjing 210098, Jiangsu, Peoples R China; [Lu, Guanghua] Tibet Agr & Anim Husb Univ, Water Conservancy Project, Linzhi 860000, Peoples R China; [Lu, Guanghua] Tibet Agr & Anim Husb Univ, Civil Engn Coll, Linzhi 860000, Peoples R China in 2019.0, Cited 50.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

The development of a novel Z-scheme system with a high separation efficiency of the charge carriers for remarkably enhanced photocatalytic activity is highly desirable. Herein, a carbon quantum dot-modified SnNb2O6/BiOCl (CQD-SNO/BOC) Z-scheme system, in which the CQDs acted as a bridge for the charge carriers, was successfully synthesized. As expected, the CQDs acted as a bridge for the charge carriers that could separate and accumulate electrons from SnNb2O6 and holes from BiOCl by promoting the transfer of the photoinduced charge carriers, which enabled the BiOCl holes to maintain their high oxidation capability. Additionally, the CQDs not only endowed the SNO/BOC Z-scheme system with a large specific surface area that provided a greater number of active sites but also noticeably improved its visible light absorption capacity. Therefore, the CQDSNO/BOC Z-scheme system showed an improved photocatalytic performance for the degradation of benzocaine (BC), which was over 20 times, 10 times and 2 times greater than those of BiOCl, SnNb2O6 and SNO/BOC Z-scheme systems, respectively. In addition, the effects of catalyst concentration, pH value, different anions, and humic acid (HA) concentration on the photodegradation of BC were investigated in depth. Simultaneously, a four-stage pathway for the degradation of BC was proposed based on the degradation products that were identified, and the accuracy of this pathway was further verified based on biotoxicity assessments and toxicity predictions of the products. According to the ESR spectra and active species trapping experiments, a mechanism for the CQD-SNO/BOC Z-scheme system was proposed, in which the CQD bridge accelerated charge transfer. Based on these results, the CQD-modified Z-scheme system could be an efficient and promising photocatalyst for the degradation of PPCPs in water.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Jiang, RR; Lu, GH; Yan, ZH; Wu, DH; Zhou, RR; Bao, XH or concate me.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Janetka, JW; Hopper, AT; Yang, ZP; Barks, J; Dhason, MS; Wang, QL; Sibley, LD in AMER CHEMICAL SOC published article about SELECTIVE-INHIBITION; GONDII; IDENTIFICATION; TRANSMISSION; ENCEPHALITIS; MECHANISM; DIAGNOSIS; INVASION; THERAPY; STRAINS in [Janetka, James W.] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA; [Barks, Jennifer; Dhason, Mary Savari; Wang, Qiuling; Sibley, L. David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; [Hopper, Allen T.; Yang, Ziping] Vyera Pharmaceut, New York, NY 10016 USA in 2020, Cited 56. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidine-4-amine (PP) compounds that are bulky ATP mimetics. Here we rationally designed, synthesized, and tested a series of novel PP analogs that were evaluated for inhibition of CDPK1 enzyme activity in vitro and parasite growth in cell culture. Optimal substitution on the PP scaffold included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing the ribose-binding pocket. Further optimization of the series led to identification of the lead compound 3a that displayed excellent potency, selectivity, safety profile, and efficacy in vivo. The results of these studies provide a foundation for further work to optimize CDPK1 inhibitors for the treatment of acute and chronic toxoplasmosis.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Janetka, JW; Hopper, AT; Yang, ZP; Barks, J; Dhason, MS; Wang, QL; Sibley, LD or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. In 2020 ADV SYNTH CATAL published article about H BOND ACETOXYLATION; HYPERVALENT IODINE(III); NENITZESCU REACTION; C(SP(3))-H; MECHANISM; HETEROCYCLES; IMPACT; ACID in [Jeyakannu, Palaniraja; Chiang, Chun-Hsien; Kumar Dhandabani, Ganesh; Chang, Yu-Ching; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan; [Chandru Senadi, Gopal] SRM Inst Sci & Technol, Fac Engn & Technol, Dept Chem, Chennai 603203, Tamil Nadu, India; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan in 2020, Cited 67. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Versatile role of lambda(3)-iodanes has been identified between the reaction of hydroquinone and beta-enaminones for the synthesis of 5-acyloxy-4-hydroxy indoles. The reaction is proposed to proceed through an intermolecular C-C bond formation, intramolecular cyclization, acyloxylation and 1,4-acyl migration. The important features of this work include various acyloxylation from lambda(3)-iodanes and broad functional group tolerance to deliver 34 examples in moderate to good yields.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Jeyakannu, P; Senadi, GC; Chiang, CH; Dhandabani, GK; Chang, YC; Wang, JJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Ohtawa, M; Yano, K; Miyao, A; Hiura, T; Sugiyama, K; Arima, S; Kita, K; Omura, S; Nagamitsu, T in PERGAMON-ELSEVIER SCIENCE LTD published article about INHIBITORS; HARZIANOPYRIDONE; NBRI23477; MECHANISM; POTENT in [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Dept Synthet Nat Prod Chem, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Med Res Labs, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Kita, Kiyoshi] Nagasaki Univ, Sch Trop Med & Global Hlth, Nagasaki 1088641, Japan; [Omura, Satoshi] Kitasato Univ, Kitasato Inst Life Sci, Tokyo 1088641, Japan in 2019.0, Cited 18.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We designed and synthesized new atpenin A5 analogs for SAR study. Most of the analogs lacked one or several functional groups in the side chain of atpenin A5, and the stereoisomers proved to be weak nematode complex 11 inhibitors. However, we determined that 4-epi-atpenin A5 was a potent nematode complex II inhibitor comparable to atpenin A5. Therefore, 4-epi-atpenin A5 is expected to become a new lead compound in nematicide development. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ohtawa, M; Yano, K; Miyao, A; Hiura, T; Sugiyama, K; Arima, S; Kita, K; Omura, S; Nagamitsu, T or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 ANTI-CANCER DRUG published article about INHIBITORS; DISCOVERY; POTENT; ANGIOGENESIS; SAR in [Huang, Yuanzheng; Zhang, Yang; Li, Jiaming; Ma, Xiaodong; Hu, Mengqi; Yang, Yu; Gao, Sufan] Anhui Acad Chinese Med, Sch Pharm, Dept Pharmaceut Chem, Hefei, Anhui, Peoples R China; [Li, Jiaming; Ma, Xiaodong] Anhui Acad Chinese Med, Dept Med Chem, Hefei, Anhui, Peoples R China in 2019, Cited 18. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of VEFGR-2 signaling. As a consequence, compounds 9k and 9s exhibited comparable or superior cytotoxic activity to that of gefitinib against the tested three cell lines, including A549, MCF-7, and PC-3. Importantly, both of them downregulated the expression of VEGFR-2, and inhibited VEGFR-2 phosphorylation at the concentration of 0.5 or 1.0 mu mol/ l. Besides, they suppressed human umbilical vein endothelial cell tube formation at the concentration of 4.0 mu mol/ l. Considering their capability of down-regulating VEGFR-2 expression and inhibiting VEGFR-2 phosphorylation, 9k and 9s may serve as suppressors of angiogenesis for further investigation. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Huang, YZ; Zhang, Y; Li, JM; Ma, XD; Hu, MQ; Yang, Y; Gao, SF or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about DIELS-ALDER REACTIONS; MANNICH-TYPE REACTION; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY; STEREOCENTERS; 2-OXINDOLES; SCAFFOLD; BEARING; DESIGN; JOINS, Saw an article supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry and Natural Science Foundation of Shanghai [16ZR1413800]. Recommanded Product: 4-Nitrobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs) has been developed. A wide range of 3-substituted oxindoles and enals were successfully used, giving the corresponding 3,3-disubstituted oxindoles containing vicinal stereogenic carbon centers in good yields with good to excellent enantioselectivities and moderate to good diastereoselectivities (up to 89% yield, 99% ee and 99 : 1 dr).

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem