Tag: M.W=150-200

An article Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists WOS:000460692100009 published article about ABA-INDEPENDENT INHIBITION; 2C PROTEIN PHOSPHATASES; MOLECULAR-BASIS; MECHANISM; ANALOGS; INSIGHTS; KINASES; COMPLEX; BINDING; CELL in [Mikame, Yu; Hirai, Go; Sodeoka, Mikiko] RIKEN Cluster Pioneering Res, Synthet Organ Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; [Mikame, Yu; Nagasawa, Kazuo] Tokyo Univ Agr & Technol, Dept Life Sci & Biotechnol, 2-24-16 Naka Cho, Koganei, Tokyo 1848588, Japan; [Yoshida, Kazuko; Hirai, Go; Osada, Hiroyuki; Sodeoka, Mikiko] RIKEN Ctr Sustainable Resource Sci, 2-1 Hirosowa, Wako, Saitama 3510198, Japan; [Hashizume, Daisuke] RIKEN Ctr Emergent Matter Sci, 2-1 Hirosowa, Wako, Saitama 3510198, Japan; [Hirai, Go; Sodeoka, Mikiko] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Category: phthalazines

The PYR/PYL/RCAR protein families have recently emerged as receptors of the phytohormone abscisic acid (ABA, 1), which regulates plant responses to environmental stress. These families have multiple members with different physiological actions, and so selective agonists or antagonists are needed both as tools to elucidate functional differences and as lead compounds for agrochemicals. We previously identified RK460 (rac-3 a) as a PYR1-selective antagonist, and showed that it possesses five stereocenters on a 6,5-cis-bicyclo skeleton. Here, we synthesized all the stereoisomers of RK460 and evaluated their activity towards a panel of receptors. Relative stereochemistry as well as absolute stereochemistry was important for selective action.

Welcome to talk about 62-23-7, If you have any questions, you can contact Mikame, Y; Yoshida, K; Hashizume, D; Hirai, G; Nagasawa, K; Osada, H; Sodeoka, M or send Email.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Unprecedented Mechanism of an Organocatalytic Route to Conjugated Enynes with a Junction to Cyclic Nitronates published in 2019. SDS of cas: 62-23-7, Reprint Addresses Gschwind, RM (corresponding author), Univ Regensburg, Fac Chem & Pharm, Univ Str 31, D-93053 Regensburg, Germany.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Conjugated enynes as well as cyclic nitronates are crucial building blocks for numerous natural products and pharmaceuticals. However, so far, no common and metal-free synthetic route to both conjugated enynes and cyclic nitronates has been reported. Herein, in situ NMR, labelling studies and theoretical calculations were combined to investigate the mechanism of the unusual triple bond formation towards conjugated enynes. Starting from nitroalkene dimers, first an isoxazolidine-2,5-diol derivative is formed as central intermediate. From this, enynes were generated by a combination of oxidation, dehydration, and retro 1,3-dipolar cycloaddition, whereas for nitronates a base induced intramolecular reorganization is proposed. While the product distribution could be controlled and high yields of nitronate were achieved, only medium to good yields for enynes were obtained due to polymerization losses. Nevertheless, we hope that these mechanistic investigations may provide a basis for further developments of organocatalytic or metal-free preparations of conjugated enynes and nitronates.

Welcome to talk about 62-23-7, If you have any questions, you can contact Streitferdt, V; Haindl, MH; Hioe, J; Morana, F; Renzi, P; von Rekowski, F; Zimmermann, A; Nardi, M; Zeitler, K; Gschwind, RM or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Mayhew, AW; Topping, DO; Hamilton, JF in AMER CHEMICAL SOC published article about PREDICTION; SCALE; BEWARE; MODEL; V1.0 in [Mayhew, Alfred W.; Hamilton, Jacqueline F.] Univ York, Dept Chem, Wolfson Atmospher Chem Labs, York YO10 5DD, N Yorkshire, England; [Topping, David O.] Univ Manchester, Manchester M13 9PL, Lancs, England in 2020, Cited 31. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Electrospray ionization (ESI) is widely used as an ionization source for the analysis of complex mixtures by mass spectrometry. However, different compounds ionize more or less effectively in the ESI source, meaning instrument responses can vary by orders of magnitude, often in hard-to-predict ways. This precludes the use of ESI for quantitative analysis where authentic standards are not available. Relative ionization efficiency (RIE) scales have been proposed as a route to predict the response of compounds in ESL In this work, a scale of RIEs was constructed for 51 carboxylic acids, spanning a wide range of additional functionalities, to produce a model for predicting the RIE of unknown compounds. While using a limited number of compounds, we explore the usefulness of building a predictor using popular supervised regression techniques, encoding the compounds as combinations of different structural features using a range of common fingerprints. It was found that Bayesian ridge regression gives the best predictive model, encoding compounds using features designed for activity coefficient models. This produced a predictive model with an R-2 score of 0.62 and a root-mean-square error (RMSE) of 0.362. Such scores are comparable to those obtained in previous studies but without the requirement to first measure or predict the physical properties of the compounds, potentially reducing the time required to make predictions.

Welcome to talk about 62-23-7, If you have any questions, you can contact Mayhew, AW; Topping, DO; Hamilton, JF or send Email.. Recommanded Product: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. In 2020 ANGEW CHEM INT EDIT published article about NATURAL-PRODUCT SYNTHESIS; ELECTROCATALYTIC APPROACH; MULTICOMPONENT REACTIONS; N-ACYL; AMIDES; AMINES; ISOIMIDES; OXIDATION in [Zhang, Xiaofeng; Cui, Ting; Zhao, Xin; Liu, Ping; Sun, Peipei] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China in 2020, Cited 61. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

Welcome to talk about 62-23-7, If you have any questions, you can contact Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP or send Email.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Dolui, P; Hazra, S; Deb, M; Elias, AJ in AMER CHEMICAL SOC published article about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION in [Dolui, Pritam; Hazra, Susanta; Deb, Mayukh; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2019.0, Cited 68.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

Welcome to talk about 62-23-7, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or send Email.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ultrasound-Assisted Synthesis of N -Acylcyanamides and N -Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine WOS:000526694900012 published article about CATALYZED CARBONYLATIVE SYNTHESIS; FACILE SYNTHESIS; CYANAMIDES; INHIBITORS; POTENT; TRIPHENYLPHOSPHINE; ISOTHIOCYANATES; QUINAZOLINONES; TRANSFORMATION; LEUCETTINES in [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Ctr Excellence Innovat Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Res Ctr Chem Dev Hlth Promoting Prod Northern Res, Chiang Mai 50200, Thailand in 2020, Cited 46. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Welcome to talk about 62-23-7, If you have any questions, you can contact Phakhodee, W; Yamano, D; Pattarawarapan, M or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 CHEMISTRYSELECT published article about BIOLOGICAL EVALUATION; PHARMACOLOGICAL-ACTIVITIES; INHIBITORS; POTENT; TRIAZOLOTHIADIAZINES; THIENOPYRIMIDINES; 1,2,4-TRIAZOLES; THIADIAZOLES; THIOPHENE in [Settypalli, Triloknadh; Chunduri, Venkata Rao; Kerru, Nagaraju; Nallapaneni, Hari Krishna] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Chintha, Venkata Ramaiah; Daggupati, Trinath; Yeguvapalli, Suneetha; Wudayagiri, Rajendra] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India in 2019, Cited 55. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid

In pursuit of neuroprotective and antimicrobial agents, a series of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole incorporated thieno[2,3-d]pyrimidine derivatives 10 a-l has been designed, synthesized. The final target compounds were screened for neuroprotective, neurotoxic and antibacterial activities. The compounds derived from 4-methylphenyl (10 a) and 4-nitrophenyl (10 c) have showed good neuroprotective activity against H2O2 induced PC12 cell death at respective EC50 values of 10.44, 14.12 mu g/mL. However 10 b and 10 k showed superior neurotoxic effects than rest of the compounds with respective CC50 values of 100.16, 120 mu g/mL. Potent antibacterial activity was shown by 10 f (R=-Me, R-2=-OMe), 10 h (R=-Me, R-2=-Cl) against the four bacterial pathogens such as S.aureus, B.subtilis, E.coli and P.aeruginosa at low minimum inhibitory concentration (MIC) range. Further, in silico docking studies were performed for all the synthesized compounds with C(30) carotenoid dehydrosqualene synthase, Gyrase A and LpxC bacterial proteins. Interestingly, 10 f, 10 h showed good binding affinities with target proteins and these results are in good compliance with the in vitro activity profile data.

Welcome to talk about 62-23-7, If you have any questions, you can contact Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R or send Email.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Semi-synthesis and anti-tumor activity of novel 25-OCH3-PPD derivatives incorporating aromatic moiety WOS:000454616600012 published article about IN-VITRO; NATURAL-PRODUCT; PANAX-GINSENG; CANCER; GINSENOSIDES; 20(S)-25-METHOXYL-DAMMARANE-3-BETA; 20-TRIOL; 12-BETA; VIVO in [Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; [Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 26. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Previously we have reported that 25-OCH3-PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC50 < 15 mu M, 5-fold to 10-fold increases than 25-OCH3-PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC50 = 6.7 +/- 0.8, 4.3 +/- 0.8 and 5.8 +/- 0.6 mu M, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds. Welcome to talk about 62-23-7, If you have any questions, you can contact Qu, FZ; Xiao, SN; Wang, XD; Zhang, Y; Su, GY; Zhao, YQ or send Email.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 J ORG CHEM published article about EFFICIENT SYNTHESIS; N-ALKYLATION; SOLVENT-FREE; REDUCTIVE FUNCTIONALIZATION; KETONE SYNTHESIS; BOND FORMATION; AMINES; ALDEHYDES; ESTERS; THIOESTERS in [Xuan, Maojie; Liu, Meina] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Xuan, Maojie; Lu, Chunlei; Lin, Bo-Lin] ShanghaiTech Univ, SPST, Shanghai 201210, Peoples R China; [Lu, Chunlei; Lin, Bo-Lin] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2019, Cited 63. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

Direct thioesterification of carboxylic acids with thiols using nontoxic activation agents is highly desirable. Herein, an efficient and practical protocol using safe and inexpensive industrial waste polymethylhydrosiloxane as the activation agent and K3PO4 with 18-crown-6 as a catalyst is described. Various functional groups on carboxylic acid and thiol substituents can be tolerated by the present system to afford thioesters in yields of 19-100%.

Welcome to talk about 62-23-7, If you have any questions, you can contact Xuan, MJ; Lu, CL; Liu, MN; Lin, BL or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM in AMER CHEMICAL SOC published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Welcome to talk about 62-23-7, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem