Tag: M.W=150-200

An article Design, Synthesis, and Biological Evaluation of (E)-N’-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents WOS:000474717400001 published article about ANDROGEN RECEPTOR ANTAGONISTS; HYDRAZIDE-HYDRAZONES; ANTIANDROGEN; DYNAMICS; ARN-509 in [Arjun, H. A.; Elancheran, Ramakrishnan; Lakshmithendral, K.; Kabilan, Senthamaraikannan] Annamalai Univ, Dept Chem, Drug Discovery Lab, Chidambaram, India; [Manikandan, N.; Ramanathan, Muthiah] PSG Coll Pharm, Dept Pharmacol, Coimbatore, Tamil Nadu, India; [Bhattacharjee, Atanu] North Eastern Hill Univ, Dept Biotechnol & Bioinformat, Computat Biol Lab, Shillong, Meghalaya, India; [Lokanath, N. K.] Univ Mysore, Dept Phys, Mysore, Karnataka, India in 2019, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late ’50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular docking approach revealed the findings of (E)-N’-((1-chloro-3,4-dihydronaphthalen-2-yl)methylene)benzohydrazide derivatives, where the possible binding modes of the compounds with protein (PDB ID: 3V49) are shown. The compounds (6a-k) were synthesized and characterized by using conventional methods. The compounds, 6g, 6j, and 6k were reconfirmed through single crystal X-ray diffraction (XRD). Further, the compounds (6a-k) and standard drug were evaluated against human prostate cancer cell lines, LNCaP and PC-3 and the non-cancerous cell line, 3T3. Among these compounds, 6g and 6j showed higher cytotoxicity, and 6g exhibited dose-dependent activity and reduced cell viability. The mechanism of action was observed through the induced apoptosis and was further confirmed by western blot and ELISA. Molecular dynamics simulation studies were carried out to calculate the interaction and the stability of the protein-ligand complex in motion. ADME properties were predicted for all the tested compounds. These findings may give vital information for further development.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Arjun, HA; Elancheran, R; Manikandan, N; Lakshmithendral, K; Ramanathan, M; Bhattacharjee, A; Lokanath, NK; Kabilan, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones WOS:000482917600008 published article about AMINO-ACIDS; 1,3-DIPOLAR CYCLOADDITION; SELECTIVE INHIBITOR; DIRECT CONVERSION; NITRILE OXIDES; ALKENES; ALKYNES; POTENT; DIPOLAROPHILES; CONSTRUCTION in [Lin, Yifan; Zhang, Ke; Gao, Mingchun; Jiang, Zheyi; Liu, Jiajie; Ma, Yurui; Wang, Haoyu; Tan, Qitao; Xiao, Junjie; Xu, Bin] Shanghai Univ, Qianweichang Coll, Sch Life Sci, Innovat Drug Res Ctr,Dept Chem, Shanghai 200444, Peoples R China; [Xu, Bin] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 61.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through C = C bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, YF; Zhang, K; Gao, MC; Jiang, ZY; Liu, JJ; Ma, YR; Wang, HY; Tan, QT; Xiao, JJ; Xu, B or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Gao, EJ; Wu, SY; Wang, J; Zhu, MC; Zhang, Y; Fedin, VP in [Gao, Enjun] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Lab Coordinat Chem, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Fedin, Vladimir P.] Nikolaev Inst Inorgan Chem, Lavrentiev Ave 3, Novosibirsk 630090, Russia published Water-Stable Lanthanide Coordination Polymers with Triple Luminescent Centers for Tunable Emission and Efficient Self-Calibration Sensing Wastewater Pollutants in 2020.0, Cited 86.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Conventional luminescent sensors relying on single emission responsive to analytes demonstrate limited sensitivity and selectivity and developing novel self-calibration probes is highly required. A series of water-stable coordination polymers (CPs) with three emitting centers for tunable emissions is reported. They are facilely synthesized by simultaneously doping red-emitting Eu3+ and green-emitting Tb3+ into the same framework. The versatile Eu0.67Tb0.33-CP is applied to conveniently distinguishing different nitroaromatics pollutants and multidimensional ratiometric sensing CrO42-/Cr2O72-. Specific nitroaromatics can cause unique changes to the ligand -> Eu3+/Tb3+ energy transfer efficiency, while CrO42-/Cr2O72- intriguingly quench the three emissions at different rates. Each nitroaromatic exhibits notably correlation to a unique combination of the two ligand -> Eu3+/Tb3+ emission intensity ratios, enabling a 2D fingerprint recognition. Furthermore, the concentration-dependent evolution of the two ratios upon exposure to CrO42-/Cr2O72- can be mapped out, achieving a 3D code recognition. As a result, the sensor demonstrates selective recognition of 4-nitrophenol and CrO42-/Cr2O72- with high sensitivity and selectivity as well as great recycling ability. Both the synthetic and sensing strategies present a promising strategy to develop facile and effective ratiometric sensors.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, EJ; Wu, SY; Wang, J; Zhu, MC; Zhang, Y; Fedin, VP or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes WOS:000515216200046 published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Ghosh, S; Banerjee, J; Ghosh, R; Chattopadhyay, SK in [Ghosh, Subhankar; Banerjee, Jeet; Ghosh, Rajat; Chattopadhyay, Shital K.] Univ Kalyani, Dept Chem, Kalyani 741235, W Bengal, India published A metal-free iodine-mediated conversion of hydroxamates to esters in 2020, Cited 38. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A metal-, oxidant-, and additive-free conversion of hydroxamates to esters have been achieved using molecular iodine as the reagent using a novel but not-so-explored heron-type rearrangement. The reaction proceeds with almost equal facility with substrates having either electron-donating or electron-withdrawing substituent. Similarly, alpha,ss-unsaturated, and sterically hindered ortho-substituted hydroxamates also undergo the desired transformation smoothly.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ghosh, S; Banerjee, J; Ghosh, R; Chattopadhyay, SK or concate me.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about STEREOSELECTIVE-SYNTHESIS; CYTOTOXIC MACROLIDES; REGIOSELECTIVE-SYNTHESIS; STRUCTURAL ELUCIDATION; N-VINYLAMIDES; ENAMIDES; AMIDES; ISOMERIZATION; AMINO; CYCLIZATION, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP15H05848, JP16K05719, JP18K19079, JP18H01977, JP19K05455]; Frontier Research Base for Global Young Researchers, Osaka University, of the MEXT program; Mitsui Chemicals Award in Synthetic Organic Chemistry; Shorai Foundation for Science and Technology. Category: phthalazines. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Suzuki, K; Nishimoto, Y; Yasuda, M. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The reaction of alpha-(carbonylamino)allylic stannanes and alkyl halides using Et3B as a radical initiator selectively afforded (E)-enamides. A radical mechanism enables the E selectivity, which is unusual in a reaction using alpha-aminoallylic metals. In addition, this reaction system achieved a wide degree of functional group tolerance and an efficient chiral transfer reaction.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Suzuki, K; Nishimoto, Y; Yasuda, M or concate me.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Xu, YW; Xu, XZ; Wu, B; Gan, CL; Lin, XY; Wang, J; Ke, F in WILEY-V C H VERLAG GMBH published article about NONACTIVATED CARBOXYLIC-ACIDS; CHEMISTRY RESEARCH AREAS; DIRECT AMIDATION; ALPHA,BETA-UNSATURATED AMIDES; C-O; AMINES; SUBSTITUTION; PERSPECTIVE; GENERATION; AMINATION in [Xu, Yiwen; Xu, Xiuzhi; Wu, Bin; Gan, Chenling; Lin, Xiaoyan; Wang, Jin; Ke, Fang] Fujian Med Univ, Inst Mat Med, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Fuzhou 350122, Peoples R China in 2020, Cited 77. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A visible-light-catalyzed radical N-acylation of amines with carboxylic acids was achieved by means of eosin Y as the photocatalyst under aqueous medium without any transition-metal-based catalytic systems. The new method takes advantages of visible-light photocatalysis to generate the amides under mild conditions. A variety of amides have been synthesized in good to excellent yields. Moreover, the strategy was successfully applied in the preparation of paracetamol.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, YW; Xu, XZ; Wu, B; Gan, CL; Lin, XY; Wang, J; Ke, F or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Retention of acidic and basic analytes in reversed phase column using fluorinated and novel eluent additives for liquid chromatography-tandem mass spectrometry published in 2020.0. HPLC of Formula: C7H5NO4, Reprint Addresses Kipper, K (corresponding author), Univ Tartu, Inst Chem, 14a Ravila St, EE-50411 Tartu, Estonia.; Kipper, K (corresponding author), St Georges Univ London, Analyt Serv Int, Cranmer Terrace, London SW17 0RE, England.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

This research focuses on retention mechanisms in a LC column with C18 stationary phase when novel eluent additives (HFIP, HFTB and TFE as well as NFTB and perfluoropinacol) are used. The retention factors between novel eluent additives and conventional ones like ammonium acetate and ammonium bicarbonate at different eluent pH values were compared. A simple set of drug-like molecules, widely spread over different logP values, containing protonated and deprotonated acids and bases was selected for this investigation. HFIP, HFTB, NFTB and PP demonstrated strong influence on basic polar analytes in basic medium. These additives drastically increased retention. A decrease in retention was observed for acidic analytes when novel eluent additives were used. Additionally, for the first time, the absolute pH (pH(abs)) scale was used for expressing the mobile phase pH. (C) 2020 The Authors. Published by Elsevier B.V.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Veigure, R; Lossmann, K; Hecht, M; Parman, E; Born, R; Leito, I; Herodes, K; Kipper, K or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors WOS:000503782700038 published article about CYCLOADDITION REACTIONS; ENANTIOSELECTIVE CYCLOADDITION; CATALYSTS; BACKBONE; DESIGN in [Ghosh, Arun K.; Grillo, Alessandro; Kovela, Satish; Brindisi, Margherita] Purdue Univ, Dept Chem, 560 Oval Dr, W Lafayette, IN 47907 USA; [Ghosh, Arun K.] Purdue Univ, Dept Med Chem & Mol Pharmacol, 560 Oval Dr, W Lafayette, IN 47907 USA; [Brindisi, Margherita] Univ Naples Federico II, Dept Excellence Pharm, Naples, Italy in 2019.0, Cited 29.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Name: 4-Nitrobenzoic acid

We describe here our investigation of the asymmetric Diels-Alder reaction of chiral 3-(acyloxy)acryloyl oxazolidinones as dienophiles in various Lewis-acid promoted reactions with cyclopentadiene. The resulting highly functionalized cycloadducts are useful intermediates for the synthesis, particularly for the optically active synthesis of 6-5-5 tricyclic hexahydro-4H-3,5-methanofuro[2,3-b]pyranol (3) with five contiguous chiral centers. This stereochemically defined crown-like heterocyclic derivative is an important high affinity ligand for a variety of highly potent HIV-1 protease inhibitors. Among the various dienophiles and Lewis acid-mediated reactions surveyed, 3-(4-methoxybenzoyl)acryloyl oxazolidinone as the dienophile and diethylaluminum chloride as the Lewis-acid provided the desired endo product with excellent diastereoselectivity. The cycloaddition was carried out in multi-gram scale and the cycloadduct was efficiently converted to alcohol 3 with high enantiomeric purity. The optically active ligand was then transformed into potent HIV-1 protease inhibitor 2.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ghosh, AK; Grillo, A; Kovela, S; Brindisi, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. I found the field of Chemistry; Materials Science very interesting. Saw the article Synthesis and Characterization of Hybrid Glycolipids as Functional Organogelators and Hydrogelators published in 2019.0, Reprint Addresses Wang, GJ (corresponding author), Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Carbohydrate-based low-molecular-weight gelators are useful and versatile compounds for the preparation of soft materials. Using N-acetyl-D-glucosamine as the starting material, we synthesized and characterized 15 glycolipids containing an amide with different ester functional groups. These include aliphatic derivatives with varying chain lengths and aromatic derivatives. Most of the hybrid amide-esters have molecular weights less than 500 D. These glycolipids were found to be effective gelators for several organic solvents, water, and aqueous solutions. Two efficient hydrogelators were also obtained at low concentrations. A few representative gels were characterized using optical microscopy, atomic force microscopy, and rheology to obtain information on their morphology and gel stability. Three gelators were also used to encapsulate naproxen sodium and toluidine blue. The sustained release of the drug from the gel to the aqueous phase was monitored by UV-vis spectroscopy. These gelators have structural flexibility that can be stimuli responsive. The esters can be hydrolyzed and several gels were converted to solutions under basic conditions. These rationally designed gelators could be utilized as stimuli-responsive smart materials with controlled release properties.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Morris, J; Kozlowski, P; Wang, GJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem