Tag: M.W=150-200

An article Effect of Cp-Ligand Methylation on Rhodium(III)-Catalyzed Annulations of Aromatic Carboxylic Acids with Alkynes: Synthesis of Isocoumarins and PAHs for Organic Light-Emitting Devices WOS:000516845200010 published article about INTERNAL ALKYNES; BENZOIC-ACIDS; CATALYZED ANNULATION; OXIDATIVE ANNULATION; ARYL IODIDES; COMPLEXES; ELECTRON; ARENE in [Molotkov, Alexander P.; Arsenov, Mikhail A.; Kapustin, Daniil A.; Muratov, Dmitry, V; Shepel’, Nikolay E.; Fedorov, Yury, V; Smol’yakov, Alexander F.; Loginov, Dmitry A.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Ul Vavilova, Moscow 119991, Russia; [Smol’yakov, Alexander F.; Knyazeva, Elena, I] RUDN Univ, Fac Sci, 6 Miklukho Maklaya St, Moscow 117198, Russia; [Smol’yakov, Alexander F.] Plekhanov Russian Univ Econ, Stremyanny Per 36, Moscow 117997, Russia; [Lypenko, Dmitry A.; Dmitriev, Artem, V; Aleksandrov, Alexey E.; Maltsev, Eugeny, I] Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Leninsky Prosp 31,Bld 4, Moscow 119071, Russia in 2020.0, Cited 72.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid

An efficient protocol was developed for the synthesis of pi-extended isocoumarins and polycyclic aromatic hydrocarbons based on the oxidative coupling of aromatic carboxylic acids with internal alkynes catalyzed by (cyclopentadienyl)rhodium complexes. The coupling chemoselectivity strongly depends on whether Cp or the methylated Cp* ligands are used. The pentamethyl derivative [Cp*RhCl2](2) predominantly gives isocoumarins, while the non-methylated complex [CpRhI2](n) produces naphthalene derivatives. The polyaromatic carboxylic acids (such as 1-naphthoic acid, 1-pyrenecarboxylic acid, fluorene-1-carboxylic acid, and dibenzofuran-4-carboxylic acid) are suitable for this approach. A mixture of Cp*H/RhCl3 can be used as a catalyst instead of [Cp*RhCl2](2). The structures of 3,4-diphenylindeno[1,2-h]isochromen-1(11H)-one and 7,10-dimethyl-8,9-diphenylbenzo[pqr]tetraphene were determined by X-ray diffraction. In addition, the optical properties of the prepared compounds were studied. 7,8-Diphenyl-10H-phenaleno[1,9-gh]isochromen-10-one was employed as an emissive layer for OLED manufacturing. The OLED emits yellow-green light with a maximum intensity 1740 cd . m(-2) at 15 V.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 EUR J MED CHEM published article about STEREOSELECTIVE TOTAL-SYNTHESIS; GENERAL DEFINITION; EFFICIENT in [Benedekovic, Goran; Popsavin, Mirjana; Kovacevic, Ivana; Rodic, Marko; Popsavin, Velimir] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad, Serbia; [Kojic, Vesna] Univ Novi Sad, Fac Med, Oncol Inst Vojvodina, Put Dr Goldmana 4, Sremska Kamenica 21204, Serbia; [Popsavin, Velimir] Serbian Acad Arts & Sci, Knez Mihajlova 35, Belgrade 11000, Serbia in 2020.0, Cited 28.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A new, modified total synthesis of (-)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available 1,2-O-isopropylidene-alpha-D-glucofuranose. The synthesis of 1 proceeds in six steps and 67% overall yield, using single-carbon atom degradation of a protected chiral precursor, (Z)-selective Wittig olefination, and acid catalyzed delta-lactonization. A new Lewis acid promoted procedure for one-pot O-debenzylation/O-acylation has been developed to complete the synthesis of natural product 1 and selected analogues. The synthesized compounds were tested in vitro to evaluate their cytotoxicity against K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549, and MRC-5 cell lines. All (-)-cleistenolide analogues exhibited significantly higher cytotoxicity than lead 1 against the majority of cell lines tested. Most of the synthesized compounds are more active than doxorubicin on at least one malignant cell line, but were almost completely inactive against normal MRC-5 cells. The structural features of the tested compounds responsible for their antiproliferative activity have been identified by preliminary SAR analysis. (C) 2020 Elsevier Masson SAS. All rights reserved.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Benedekovic, G; Popsavin, M; Kovacevic, I; Kojic, V; Rodic, M; Popsavin, V or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. Haito, A; Chatani, N in [Haito, Akira; Chatani, Naoto] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan published Rh(i)-Catalyzed [3+2] annulation reactions of cyclopropenones with amides in 2019.0, Cited 28.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Rh(I)-Catalyzed [3+ 2] annulation reactions of cyclopropenones with amides are reported. The reaction provides a direct approach for producing highly substituted alpha, beta-unsaturated gamma-lactam derivatives. The presence of an N(sp(2)) atom in the N-alkyl group of the amide, such as the 2-pyridinylmethyl or 8-aminoquinonyl group, is essential for the success of the reaction.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Haito, A; Chatani, N or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 ANGEW CHEM INT EDIT published article about NATURAL-PRODUCT SYNTHESIS; ELECTROCATALYTIC APPROACH; MULTICOMPONENT REACTIONS; N-ACYL; AMIDES; AMINES; ISOIMIDES; OXIDATION in [Zhang, Xiaofeng; Cui, Ting; Zhao, Xin; Liu, Ping; Sun, Peipei] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China in 2020, Cited 61. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition WOS:000551552600048 published article about PICTET-SPENGLER REACTIONS; SP(3) C-H; INDOLE SYNTHESIS; IODINE(III) REAGENTS; AMINATION; EFFICIENT; FUNCTIONALIZATION; BONDS; TETRAHYDROISOQUINOLINES; ALKYLATION in [Choi, Subin; Oh, Hyeonji; Sim, Jeongwoo; Yu, Eunsoo; Park, Cheol-Min] UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; [Shin, Seunghoon] Hanyang Univ, Dept Chem, Seoul 04763, South Korea in 2020.0, Cited 73.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The synthesis of versatile scaffold indolopyrans based on C-C radical-radical cross-coupling under metal-free conditions is described. The reaction involving single electron transfer between coupling partners followed by cage collapse allows highly selective cross-coupling while employing only equimolar amounts of coupling partners. Moreover, the mechanistic manifold was expanded for the functionalization of enamines to give the stereoselective synthesis of 2,3-dihydrofurans. This iodine-mediated oxidative coupling features mild conditions and fast reaction kinetics.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Choi, S; Oh, H; Sim, J; Yu, E; Shin, S; Park, CM or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. In 2020 J ORG CHEM published article about CIRCULARLY-POLARIZED LUMINESCENCE; PROBES; DERIVATIVES; VERSATILE; SOLVENT; DESIGN; STATE; RED in [Banuelos, Jorge; Arbeloa, Teresa] Univ Basque Country, EHU, Dept Quim Fis, Fac Ciencia & Tecnol, E-48080 Bilbao, Spain; [Ray, Cesar; Schad, Christopher; Moreno, Florencio; Maroto, Beatriz L.; de la Moya, Santiago] Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, E-28040 Madrid, Spain; [Garcia-Moreno, Inmaculada] CSIC, Inst Quim Fis Rocasolano, Dept Sistemas Baja Dimensionalidad Superficies &, E-28006 Madrid, Spain; [Villafuerte, Cassie; Muller, Gilles] San Jose State Univ, Dept Chem, San Jose, CA 95192 USA in 2020, Cited 39. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A general and straightforward method for the synthesis of COO-BODIPYs from F-BODIPYs and carboxylic acids is established. The method is based on the use of boron trichloride to activate the involved substitution of fluorine, which leads to high yields through rapid reactions under soft conditions. This mild method opens the way to unprecedented laser dyes with outstanding efficiencies and photostabilities, which are difficult to obtain by the current methods.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ray, C; Schad, C; Moreno, F; Maroto, BL; Banuelos, J; Arbeloa, T; Garcia-Moreno, I; Villafuerte, C; Muller, G; de la Moya, S or concate me.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. In 2019 CHEM COMMUN published article about H AMIDATION; BOND AMIDATION; FUNCTIONALIZATION; ACTIVATION; AMINATION; 1H-INDAZOLES; COBALT(III); AZIDES; HETEROCYCLES; AZOBENZENES in [Yang, Jingshu; Hu, Xiao; Li, Xueyuan; Liu, Gang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, Beijing Key Lab Active Subst Discovery & Druggabi, Inst Mat Med, Beijing 100050, Peoples R China in 2019, Cited 83. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A Cp*Co-III-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about C-H BONDS; BENZOIC-ACID; MOLECULAR-OXYGEN; N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; METAL-FREE; PHOTOOXIDATION; DERIVATIVES; COBALT; OXIDE, Saw an article supported by the National Key Research and Development Program of China [2017YFC0210900]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Safety of 4-Nitrobenzoic acid

A mild and metal-free procedure is reported for the aerobic oxidation of substituted toluenes to carboxylic acids by using CBr (4) as initiator under irradiation from a 400 nm blue light-emitting diode.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CASCADE REACTIONS; MICHAEL REACTION; CONDENSATIONS; CONSTRUCTION, Saw an article supported by the Shanghai Pujiang ProgramShanghai Pujiang Program [KBH1615505]. Name: 4-Nitrobenzoic acid. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hu, S; Wang, JQ; Huang, GX; Zhu, KJ; Chen, F. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

An organocatalytic asymmetric enantioselective domino oxa-Michael-Mannich-[1,3]-amino rearrangement reaction of N-tosylsalicylimines with a wide range of alpha,beta-unsaturated aldehydes utilizing diarylprolinol silyl ether catalysis is described. The catalytic reactions proceed with excellent enantioselectivity (up to 99% ee) to produce the corresponding chair N-tosylimines-chromenes with a yield of up to 99%, tolerating a range of functional groups. This methodology offers a new method with great potential to further extend the synthetic power and versatility of chiral aminocatalysis.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, S; Wang, JQ; Huang, GX; Zhu, KJ; Chen, F or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease WOS:000491219000019 published article about BETA-AMYLOID AGGREGATION; ACETYLCHOLINESTERASE INHIBITOR; ACID-DERIVATIVES; DIRECTED LIGANDS; DESIGN; PEPTIDE; ASSAY; SITE; BUTYRYLCHOLINESTERASE; NEUROTOXICITY in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India in 2019, Cited 80. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem