Tag: M.W=150-200

Authors Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR in SPRINGER WIEN published article about PASSERINI REACTION; MULTICOMPONENT REACTIONS; MEDIA; GREEN in [Yavari, Issa; Khajeh-Khezri, Aliyeh; Ghorbanzadeh, Meysam] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran; [Halvagar, Mohammad Reza] Chem & Chem Engn Res Ctr Iran, Dept Inorgan Chem, POB 14335-186, Tehran, Iran in 2019, Cited 27. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The Passerini three-component reaction between acenaphthylene-1,2-dione, alkyl isocyanides, and carboxylic acids, leading to the formation of alpha-acyloxyamides in common organic solvents (CH2Cl2, MeOH) and choline chloride-based deep eutectic solvent, is described. The reaction in the latter solvent proceeded faster compared to common organic solvents. The structure of a typical product was confirmed by X-ray crystallography. [GRAPHICS] .

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. I found the field of Chemistry very interesting. Saw the article 1,3,5-Triazinanes as Formaldimine Surrogates in the Ugi Reaction published in 2020, Reprint Addresses Golubev, P (corresponding author), St Petersburg Stare Univ, Inst Chem, 26 Univ Sky Prospect, Peterhof 198504, Russia.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

In the present study, a new synthetic strategy towardsN-acylated glycinamides was developed by the use of 1,3,5-triazinanes as formaldimine surrogates in the Ugi reaction. The targeted products were obtained in a combinatorial, diversity-oriented fashion in good yields. Further modifications allowed us to adapt this procedure for the one-pot two-step syntheses of a local anesthetic druglidocaine and several unsymmetrically substituted diketopiperazines.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Golubev, P; Guranova, N; Krasavin, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. In 2019 FRONT CHEM published article about ANDROGEN RECEPTOR ANTAGONISTS; HYDRAZIDE-HYDRAZONES; ANTIANDROGEN; DYNAMICS; ARN-509 in [Arjun, H. A.; Elancheran, Ramakrishnan; Lakshmithendral, K.; Kabilan, Senthamaraikannan] Annamalai Univ, Dept Chem, Drug Discovery Lab, Chidambaram, India; [Manikandan, N.; Ramanathan, Muthiah] PSG Coll Pharm, Dept Pharmacol, Coimbatore, Tamil Nadu, India; [Bhattacharjee, Atanu] North Eastern Hill Univ, Dept Biotechnol & Bioinformat, Computat Biol Lab, Shillong, Meghalaya, India; [Lokanath, N. K.] Univ Mysore, Dept Phys, Mysore, Karnataka, India in 2019, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late ’50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular docking approach revealed the findings of (E)-N’-((1-chloro-3,4-dihydronaphthalen-2-yl)methylene)benzohydrazide derivatives, where the possible binding modes of the compounds with protein (PDB ID: 3V49) are shown. The compounds (6a-k) were synthesized and characterized by using conventional methods. The compounds, 6g, 6j, and 6k were reconfirmed through single crystal X-ray diffraction (XRD). Further, the compounds (6a-k) and standard drug were evaluated against human prostate cancer cell lines, LNCaP and PC-3 and the non-cancerous cell line, 3T3. Among these compounds, 6g and 6j showed higher cytotoxicity, and 6g exhibited dose-dependent activity and reduced cell viability. The mechanism of action was observed through the induced apoptosis and was further confirmed by western blot and ELISA. Molecular dynamics simulation studies were carried out to calculate the interaction and the stability of the protein-ligand complex in motion. ADME properties were predicted for all the tested compounds. These findings may give vital information for further development.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Arjun, HA; Elancheran, R; Manikandan, N; Lakshmithendral, K; Ramanathan, M; Bhattacharjee, A; Lokanath, NK; Kabilan, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 RSC ADV published article about HIGHLY SELECTIVE DETECTION; METAL-ORGANIC FRAMEWORKS; POLYMER NANOPARTICLES; FLUORESCENT; CHEMOSENSORS; EXPLOSIVES; EMISSION; SENSORS in [Makkad, Sarabjot Kaur] Govt Autonomous NPG Coll Sci, Raipur, Madhya Pradesh, India; [Makkad, Sarabjot Kaur] Natl Chem Lab, CSIR, Pune, Maharashtra, India in 2020.0, Cited 29.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

A solution as well as solid state based sensor has been developed for selective detection of picric acid (PA) in water. Oligo (p-phenylenevinylene) (OPV) incorporated polystyrene nanobeads (PS-OPV-NH2) having an average size of 180 nm have been synthesized through miniemulsion polymerization. Amine (-NH2) functionalization was performed on the nanobead surface to enhance the efficiency of the sensor among a library of other nitro-organics and library of cations and anions.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Makkad, SK or concate me.. COA of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Skok, Z; Durcik, M; Skledar, DG; Barancokova, M; Masic, LP; Tomasic, T; Zega, A; Kikelj, D; Zidar, N; Ilas, J in [Skok, Ziga; Durcik, Martina; Skledar, Darja Gramec; Barancokova, Michaela; Masic, Lucija Peterlin; Tomasic, Tihomir; Zega, Anamarija; Kikelj, Danijel; Zidar, Nace; Ilas, Janez] Univ Ljubljana, Fac Pharm, Askerceva Cesta 7, Ljubljana 1000, Slovenia published Discovery of new ATP-competitive inhibitors of human DNA topoisomerase II alpha through screening of bacterial topoisomerase inhibitors in 2020.0, Cited 50.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Human DNA topoisomerase II is one of the major targets in anticancer therapy, however ATP-competitive inhibitors of this target have not yet reached their full potential. ATPase domain of human DNA topoisomerase II belongs to the GHKL ATPase superfamily and shares a very high 3D structural similarity with other superfamily members, including bacterial topoisomerases. In this work we report the discovery of a new chemotype of ATP-competitive inhibitors of human DNA topoisomerase II alpha that were discovered through screening of in-house library of ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV. Systematic screening of this library provided us with 20 hit compounds. 1,2,4-Substituted N-phenylpyrrolamides were selected for a further exploration which resulted in 13 new analogues, including 52 with potent activity in relaxation assay (IC50 = 3.2 mu M) and ATPase assay (IC50 = 0.43 mu M). Cytotoxic activity of all hits was determined in MCF-7 cancer cell line and the most potent compounds, 16 and 20, showed an IC50 value of 8.7 and 8.2 mu M, respectively.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Skok, Z; Durcik, M; Skledar, DG; Barancokova, M; Masic, LP; Tomasic, T; Zega, A; Kikelj, D; Zidar, N; Ilas, J or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against beta-glucuronidase and their interactions thereof WOS:000572832200005 published article about IN-VITRO EVALUATION; ALPHA-GLUCOSIDASE INHIBITION; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; SCHIFF-BASES; DERIVATIVES; ACETYLCHOLINESTERASE; THIOSEMICARBAZIDES; CHILDREN; ANALOGS in [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Uddin, Nizam] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ali, Muhammad] Univ Nizwa, Nat & Med Sci Res Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman; [Anouar, El Hassane] Prince Sattam bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Chem, Al Kharj 11942, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Gulraiz] Imam Abdulrahman Bin Faisal Univ, Environm Engn Dept, Coll Engn Bldg A13,POB 1982, Dammam 31441, Saudi Arabia; [Farooq, Rai Khalid] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Neurosci Res, POB 1982, Dammam 31441, Saudi Arabia; [Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, Coll Comp Sci & Informat Technol CCSIT, Dept Comp Informat Syst, POB 1982, Dammam 31441, Saudi Arabia; [Iqbal, Naveed] Univ Poonch Rawalakot AJK, Dept Chem, Rawalakot, Pakistan; [Farooq, Muhammad] Hazara Univ, Dept Phys, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan in 2020, Cited 54. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

beta-Glucuronidase is responsible for the catalytic deconjugation of beta-D-glucuronides. beta-Glucuronidase has evolved to be a viable molecular target for numerous therapeutic treatments. It plays a pivotal role in the metabolism of drugs and endogenous substances. Herein, we report the inhibitory potentials of newly developed and modular benzimidazole-triazolothiadiazole hybrids spaced through a phenyl linker (1-26) and their interactions with the beta-glucuronidase. All analogues showed IC50 values in the range of 1.30 +/- 0.10 to 44.10 +/- 0.80 mu M, and hence were found to have outstanding inhibitory potential as compare to the standard D-saccharic acid 1,4-lactone (IC50 = 48.4 +/- 1.25 mu M). These modular hybrids were successfully synthesized, rigorously characterized through various spectroscopic techniques. Molecular docking studies further revealed the potential interactions between the inhibitor and active amino acid site in beta-glucuronidase. These findings helped in identifying the potential for new drug candidates. A Plausible structure activity relationship (SAR) were established which suggested that variation in the inhibitory potential was mainly based upon the substituents attached to the phenyl ring. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Taha, M; Uddin, N; Ali, M; Anouar, E; Rahim, F; Khan, G; Farooq, RK; Gollapalli, M; Iqbal, N; Farooq, M; Khan, KM or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about COUPLINGS; ANTIBIOTICS; LIGAND, Saw an article supported by the JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [16H05097, 18H04599]; Hokkaido University; Global Facility Center (GFC); Pharma Science Open Unit (PSOU); MEXT under Support Program for Implementation of New Equipment Sharing System, the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research; BINDS) from the Japan A. Formula: C7H5NO4. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kitahata, S; Katsuyama, A; Ichikawa, S. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A synthesis strategy for the production of a key synthetic intermediate of gulmirecin A was described. The key reaction in the preparation of the 12-membered macrolactone is the Ni(0)-mediated reductive cyclization reaction of ynal using an N-heterocyclic carbene ligand and silane reductant. In addition, the alpha-selective glycosylation reaction of the macrolactone was performed to demonstrate the synthesis of gulmirecin and disciformycin precursors.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Kitahata, S; Katsuyama, A; Ichikawa, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Mannich base Cu(II) complexes as biomimetic oxidative catalyst WOS:000469408500017 published article about CATECHOL OXIDASE ACTIVITY; GALACTOSE-OXIDASE; SCHIFF-BASE; DICOPPER(II) COMPLEXES; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; POLYPHENOL OXIDASE; METAL-COMPLEXES; MONONUCLEAR; DINUCLEAR in [Kundu, Bidyut Kumar; Ranjan, Rishi; Mobin, Shaikh M.; Mukhopadhyay, Suman] Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Khandwa Rd, Indore 453552, Madhya Pradesh, India; [Mukherjee, Attreyee] Ananda Mohan Coll, Dept Chem, Kolkata 700009, India; [Mukhopadhyay, Suman] Indian Inst Technol Indore, Sch Engn, Discipline Biosci & Biomed Engn, Khandwa Rd, Indore 453552, Madhya Pradesh, India in 2019.0, Cited 58.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Galactose Oxidase (GOase) and catechol oxidase (COase) are the metalloenzymes of copper having monomeric and dimeric sites of coordination, respectively. This paper summarizes the results of our studies on the structural, spectral and catalytic properties of new mononuclear copper (II) complexes [CuL(OAc)] (1), and [CuL2] (2), (HL = 2,4-dichloro-6-{[(2′-dimethyl-aminoethyl)methylamino]methyl}-phenol) which can mimic the functionalities of the metalloenzymes GOase and COase. The structure of the compounds has been elucidated by X-ray crystallography and the mimicked Cu(II) catalysts were further characterized by EPR. These mimicked models were used for GOase and COase catalysis. The GOase catalytic results were identified by GC MS and, analyzed by HPLC at room temperature. The conversion of benzyl alcohol to benzaldehyde were significant in presence of a strong base, Bu4NOMe in comparison to the neutral medium. Apart from that, despite of being monomeric in nature, both the homogeneous catalysts are very prone to participate in COase mimicking oxidation reaction. Nevertheless, during COase catalysis, complex 1 was found to convert 3,5-ditertarybutyl catechol (3,5-DTBC) to 3,5-ditertarybutyl quinone (3,5-DTBQ) having greater rate constant, k(cat) or turn over number (TON) value over complex 2. The generation of reactive intermediates during COase catalysis were accounted by electrospray ionization mass spectrometry (ESI-MS). Through mechanistic approach, we found that H2O2 is the byproduct for both the GOase and COase catalysis, thus, confirming the generation of reactive oxygen species during catalysis. Notably, complex 1 having mono-ligand coordinating atmosphere has superior catalytic activity for both cases in comparison to complex 2, that is having di-ligand environment.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kundu, BK; Ranjan, R; Mukherjee, A; Mobin, SM; Mukhopadhyay, S or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity published in 2020, Reprint Addresses Jiang, C (corresponding author), China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

LDH1A1, one of 19 NAD(P)(+)-dependent aldehyde dehydrogenases, participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes. In this study, a series of 1,3-di-methylpyrimidine-2,4-diones were designed, synthesized and evaluated as novel selective aldehyde dehy-drogenase 1A1 inhibitors. Among them, compounds 46, 50, 53, 56 and 57 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low nanomolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Furthermore, in vitro study demonstrated that compound 57 effectively improved glucose consumption in HepG2 cells compared to compound 1 (CM026).

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, ZH; Jiang, L; Li, GX; Liang, DL; Li, LF; Liu, L; Jiang, C or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ruthenium-Catalyzed Regioselective Olefin Migration of Dihydropyran Acetals: A De Novo Strategy toward beta-2,6-Dideoxypyranoglycosides WOS:000526331100013 published article about STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; GLYCOSYLATION; 2-DEOXY-BETA-GLYCOSIDES; DIGITOXIN; SUGARS; ANTIBIOTICS; DONORS in [Seo, Kyeongdeok; Rhee, Young Ho] POSTECH, Dept Chem, Pohang 37673, South Korea in 2020.0, Cited 47.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Here, we report a de novo synthetic strategy toward beta-2,6-dideoxypyranoglycosides. The key event is the ruthenium-catalyzed regioselective olefin migration of dihydropyran allylic acetals to homoallylic acetals. In combination with other metal-catalyzed reactions, this new protocol led to the synthesis of beta-2,6-dideoxypyranoglycosides in a highly efficient manner. Using this sequential metal catalysis, various mono-, di-, and trisaccharide forms of beta-2,6-dideoxypyranoglycosides were prepared.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Seo, K; Rhee, YH or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem