Tag: M.W=150-200

An article Palladium-Catalyzed C(sp(2))-H Activation for the Formation of C-N Bonds: Rapid Access to Benzimidazoquinazolines WOS:000461576000019 published article about DIRECTING GROUP; COPPER; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; QUINAZOLINES; CHEMISTRY; ARYLATION; DESIGN in [Guo, Xiaolong; Hu, Jing; Zhang, Mengmeng; Wang, Luyao] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China in 2019.0, Cited 51.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

A convenient and effective method for Pd-catalyzed cross-dehydrogenative C(sp(2))-H/N-H couplings to synthesize fused N-heterocyclic benzimidazoquinazoline derivatives was developed. The reaction employs Pd(OAc)(2) as the catalyst and Cu(OAc)(2) or O-2 (from the air) as the terminal oxidant. The strategy uses simple and easily accessible substrates. This method provides a route to azole-fused heterocycles.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG BIOMOL CHEM published article about COMBINATORIAL BIOSYNTHESIS; ACYLTRANSFERASE DOMAIN; SUBSTRATE-SPECIFICITY; SYNTHASE MODULE; ASSEMBLY LINES; THIOESTERASE; MECHANISM; PRODUCT; KETOSYNTHASE; MONENSIN in [Grote, Marius; Kushnir, Susanna; Pryk, Niclas; Moeller, David; Erver, Julian; Ismail-Ali, Ahmed; Schulz, Frank] Ruhr Univ Bochum, Fak Chem & Biochem, AG Nat Stoffchem & Biochem, Organ Chem 1, Univ Str 150, D-44780 Bochum, Germany in 2019.0, Cited 64.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

The concept of combinatorial biosynthesis promises access to compound libraries based on privileged natural scaffolds. Ever since the elucidation of the biosynthetic pathway towards the antibiotic erythromycin A in 1990, the predictable manipulation of type I polyketide synthase megaenzymes was investigated. However, this goal was rarely reached beyond simplified model systems. In this study, we identify the intermediates in the biosynthesis of the polyether monensin and numerous mutated variants using a targeted metabolomics approach. We investigate the biosynthetic flow of intermediates and use the experimental setup to reveal the presence of selectivity filters in polyketide synthases. These obstruct the processing of non-native intermediates in the enzymatic assembly line. Thereby we question the concept of a truly modular organization of polyketide synthases and highlight obstacles in substrate channeling along the cascade. In the search for the molecular origin of a selectivity filter, we investigate the role of different thioesterases in the monensin gene cluster and the connection between ketosynthase sequence motifs and incoming substrate structures. Furthermore, we demonstrate that the selectivity filters do not apply to new-to-nature side-chains in nascent polyketides, showing that the acceptance of these is not generally limited by downstream modules.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT in [Shouksmith, Andrew E.; Gawel, Justyna M.; Nawar, Nabanita; Sina, Diana; Raouf, Yasir S.; Bukhari, Shazreh; He, Liying; Johns, Alexandra E.; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O.; Cabral, Aaron D.; Sedighi, Abootaleb; de Araujo, Elvin D.; Gunning, Patrick T.] Univ Toronto Mississauga, Dept Chem & Phys Sci, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada published Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia in 2020.0, Cited 25.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24% 5-year survival rate. Through screening of low-molecular-weight analogues derived from the previously discovered novel HDAC inhibitor, AES-135, compound 51 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. Compound 51 also demonstrated improved oral bioavailability compared to SAHA in mouse models. A broad spectrum of experiments, including FACS, ELISA, and Western blotting, were performed to support our hypothesis that 51 dose-dependently triggers apoptosis in AML cells through HDAC inhibition.

HPLC of Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D in SPRINGER BIRKHAUSER published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ELLIPTICINE DERIVATIVES; AMIDE DERIVATIVES; POTENT; INHIBITORS; ANALOGS; DISCOVERY; BINDING; SERIES in [Kala, Pruthu; Khasim Sharif, Syed; Ramachandran, Dittakavi] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India; [Murali Krishna, CH.] Adikavi Nannaya Univ, Dept Chem, Rajamahendravaram 533296, Andhra Pradesh, India in 2020, Cited 57. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a-j) were synthesized and their structures were confirmed by H-1 NMR, (CNMR)-C-13 and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kala, P; Sharif, SK; Krishna, CM; Ramachandran, D or send Email.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors published in 2019.0, Reprint Addresses Zhu, Y (corresponding author), China Pharmaceut Univ, Sch Sci, Dept Organ Chem, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China.; Lu, T (corresponding author), China Pharmaceut Univ, Sch Sci, Lab Mol Design & Drug Discovery, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Histone deacetylase (HDAC) inhibitors as an important epigenetic therapeutic strategy affect signaling networks and act synergistically with kinase inhibitors for the treatment of cancer. Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays. This work may lay the foundation for developing novel dual Raf/HDAC inhibitors as potential anticancer therapeutics.

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Geng, AX; Cui, H; Zhang, LY; Chen, X; Li, HM; Lu, T; Zhu, Y or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Liang, DL; Fan, YZ; Yang, Z; Zhang, ZG; Liu, MY; Liu, L; Jiang, C in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about ACETALDEHYDE; ADDUCTS; DNA in [Liang, Dailin; Yang, Zhou; Zhang, Zhenguo; Jiang, Cheng] China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Liang, Dailin; Yang, Zhou; Zhang, Zhenguo; Liu, Meiyang; Jiang, Cheng] China Pharmaceut Univ, Dept Med Chem, Tongjiaxiang 24, Nanjing 210009, Peoples R China; [Fan, Yazhou; Liu, Li] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Tongjiaxiang 24, Nanjing 210009, Peoples R China in 2020.0, Cited 26.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) is associated with the occurrence and development of obesity and insulin resistance. Herein, a series of coumarin-based ALDH1A1 inhibitors were designed, synthesized and evaluated. Among them, compounds 10, 14 and 26 exhibited potent inhibitory activity against ALDH1A1 and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Optimized compound 10 showed markedly improved pharmacokinetic characters and ADME profiles comparing to the lead compound 1. In vitro study demonstrated that 10 alleviated palmitic acid-induced impairment of glucose consumption in HepG2 cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 62-23-7, If you have any questions, you can contact Liang, DL; Fan, YZ; Yang, Z; Zhang, ZG; Liu, MY; Liu, L; Jiang, C or send Email.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Rh(III)-Catalyzed Intramolecular Oxidative Annulation of Propargyl Amino Phenyl Benzamides to Access Pyrido/ Isoquinolino Quinoxalinones published in 2019. Computed Properties of C7H5NO4, Reprint Addresses Reddy, MS (corresponding author), CSIR, OSPC Div, Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India.; Reddy, MS (corresponding author), Acad Sci & Innovat Res, New Delhi 110001, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A rhodium catalyzed copper mediated double oxidative annulation of propargylamino phenyl benzamides is developed. A quick assembly of tri, tetra and penta cyclic pyrido/isoquinolo-quinoxilines are thus achieved from readily available linear substrates. The reaction is shown to be very general by accommodating a large variety of substrates in the transformation. A mechanism through an amide directed C-H bond activation followed by an intramolecular alkyne activation/annulation followed by an oxidation is postulated.

Welcome to talk about 62-23-7, If you have any questions, you can contact Kumar, GR; Kumar, R; Rajesh, M; Sridhar, B; Reddy, MS or send Email.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 EUR J MED CHEM published article about MATRIX-METALLOPROTEINASE INHIBITORS; CANCER-CELL INVASION; BREAST-CANCER; MATRIX-METALLOPROTEINASE-9 ACTIVITY; CRYSTAL-STRUCTURES; TUMOR-GROWTH; DESIGN; ROLES; MULTICOMPONENT; OVEREXPRESSION in [Ayoup, Mohammed Salah; Fouad, Manar Ahmed; Abdel-Hamid, Hamida; Ramadan, El Sayed] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt; [Abu-Serie, Marwa M.] City Sci Res & Technol Applicat SRTA City, Genet Engn & Biotechnol Res Inst, Med Biotechnol Dept, Alexandria, Egypt; [Noby, Ahmed] Pharos Univ Alexandria, Fac Pharm, Dept Microbiol & Immunol, Alexandria 21311, Egypt; [Teleb, Mohamed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt in 2020.0, Cited 84.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ORGANIC ELECTROOPTIC MATERIALS; NONLINEAR-OPTICAL-PROPERTIES; STABILITY; THIAZOLE; DESIGN; THIOPHENE; MONOMERS, Saw an article supported by the UGC, New Delhi under the CPEPA Program [8-2/2008(NS/PE)]; DST-PURSE-Phase-II Program [SR/PURSE Phase 2/12(G)]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Doddamani, RV; Rachipudi, PS; Pattanashetti, NA; Kariduraganavar, MY. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. SDS of cas: 62-23-7

This paper emphasizes the preparation of nonlinear optical (NLO) responsive chromophores and their corresponding polymers. Initially, the carboxyl acid group-based precursors of the chromophores containing strong acceptors such as nitro-substituted thiazole and thiadiazole groups were prepared and subjected to condensation reactions with a monomer to yield a series of polymers. Prior to the synthesis of the polymers, a thermally crosslinkable monomer, 2,6-di-(octy-1-nyl)-p-phenylenediamine, was synthesized by a Sonogashira coupling reaction. All the synthesized precursors, the monomer and their corresponding polymers were characterized using FTIR, H-1 NMR, and CHN analyses and UV-Vis spectrophotometry. Simultaneously, the molecular structures of the precursors were designed and optimized using the Gaussian 16 (Revision A.03) program. The dipole moments, energy band gaps between the HOMO and LUMO, polarizabilities and first order hyperpolarizabilities of the precursors were calculated theoretically using the DFT approach; the values were in the ranges of 9.4321-15.3354 D, 1.3709-1.4146 eV, 53.40-64.80 x 10(-24) esu and 3703.35-5254.90 x 10(-32) esu, respectively. The inherent viscosities (eta inh) of the polymers were measured by an Ubbelohde viscometer and were in the range of 0.2453-0.2860 dl g(-1). The thermal behavior of the polymers was investigated using DSC and TGA. The glass transition temperatures of the polymers were in the range of 190-218 degrees C. The thicknesses and refractive indices of the thin films were determined by ellipsometry, and the values were in the range of 0.100-0.127 mu m and 1.211-1.426, respectively. The molecular orientations in the thin polymer films were induced by corona poling and were ascertained using both a UV-Vis spectrophotometer and an atomic force microscope. The second harmonic generations (SHGs) of the poled polymers were determined using an Nd-YAG laser. The SHG coefficients (d(33)) ranged between 98.30 and 106.04 pm V-1 at 532 nm. Among the synthesized polymers, the polymer containing dinitro-substituted thiazole demonstrated an excellent SHG coefficient as high as 106.04 pm V-1. Furthermore, none of the polymers showed SHG decay below 100 degrees C, and they retained 95% of their SHG values even up to 600 h. Based on its enhanced NLO efficiency and long temporal stability, the polymer containing dinitro-substituted thiazole can be a particularly promising candidate for photonic devices.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article One-pot and regioselective synthesis of polysubstituted 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by sequential Ugi/Staudinger/aza-Wittig reaction WOS:000458708500011 published article about FACILE SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS; COUPLING REACTION; DERIVATIVES; CYCLIZATION; ACCESS; SERIES; ROUTE; CELLS in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China in 2019.0, Cited 59.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem