Tag: M.W=150-200

An article Tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides: One-pot synthesis of heterocyclemcs WOS:000466451800016 published article about EFFICIENT SYNTHESIS; CRYSTAL-STRUCTURE; STEREOSELECTIVE-SYNTHESIS; CHEMICAL-SYNTHESIS; ISONITRILES; ALPHA; DERIVATIVES; CASCADE; FACILE in [Liu, Ming-Guo; Liu, Na; Xu, Wen-Heng; Wang, Long] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmetall Crystalline & Energy Co, Yichang 443002, Hubei, Peoples R China in 2019.0, Cited 103.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

This paper reports the tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides. According to this strategy, plenty of isocyanides have been synthesized, which is immediately used for the tandem reaction of Passerini/Wittig reaction in one pot. Compared to the previous work, this strategy avoids the separation, purification, and storage of isocyanides, which prominently solves the problems of isocyanide-based multicomponent reaction such as: (a) The environmentally unfriendly (strong foul odor), (a) the labile of isocyanides, (c) high toxicity of isocyanides. In the meantime, in order to expand the application scope of our strategy, 1H-isochromenes and 3H-2-benzoxepin-1-ones have also been synthesized, which undergoes four-step transformations in one-pot. In addition, a relatively credible reaction mechanism has also been proposed, based on a series of control experiments. Furthermore, preliminary testing was performed on biological activity of some obtained compounds; These results showed that the synthesized compounds exhibited certain activity over P. digitatum and P. italicum. (C) 2019 Elsevier Science. All rights reserved. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Liu, MG; Liu, N; Xu, WH; Wang, L or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 CHEM BIODIVERS published article about ANTIOXIDANT ACTIVITIES; ANTIMICROBIAL ACTIVITY; THIOUREA DERIVATIVES; OXIDATIVE STRESS; L. in [Aziz, Hamid; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Khan, Muhammad Aslam; Afridi, Shakeeb] Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan; [Jabeen, Farukh] Laurentian Univ, Dept Biol, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada; [Jabeen, Farukh] Computat Sci Res & Dev Org, 1401,2485 Hurontraio St, Mississauga, ON L5A 2G6, Canada; [Ashfaq-ur-Rehman] Abdul Wali Khan Univ, Dept Biochem, Shankar Campus, Mardan 23200, Khyber Pukhtoon, Pakistan; [Ashfaq-ur-Rehman] Shanghai Jiao Tong Univ, Dept Bioinformat & Biostat, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Hashim, Muhammad] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan in 2020, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

The present study reports the convenient synthesis, spectroscopic characterization, bio-assays and computational evaluation of a novel series of N-acyl-1H-imidazole-1-carbothioamides. The screened derivatives displayed excellent antioxidant activity, moderate antibacterial and antifungal potential. The screened derivatives were found to be highly biocompatible against hRBCs. Molecular docking ascertained the mechanism and mode of action towards the molecular target delineating that ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces in accordance to the corresponding experimental results. Docking simulation provided additional information about the possibilities of inhibitory potential of the compounds against RNA. Computational evaluation predicted that N-acyl-1H-imidazole-1-carbothioamides 5c and 5g can serve as potential surrogates for hit to lead generation and design of novel antioxidant and antibacterial agents.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Aziz, H; Saeed, A; Khan, MA; Afridi, S; Jabeen, F; Ashfaq-ur-Rehman; Hashim, M or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents WOS:000467320000058 published article about SUZUKI CROSS-COUPLINGS; ALLYLIC SUBSTITUTION; HALIDES in [Shinohara, Riku; Morita, Masao; Kobayashi, Yuichi] Tokyo Inst Technol, Dept Bioengn, Midori Ku, Box B-52,Nagatsuta Cho 4259, Yokohama, Kanagawa 2268501, Japan; [Ogawa, Narihito] Meiji Univ, Dept Appl Chem, Tama Ku, 1-1-1 Higashimita, Kawasaki, Kanagawa 2148571, Japan in 2019, Cited 44. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Investigation of the copper-catalyzed coupling reaction of 2-pyridinesulfonates with Grignard reagents revealed that reactions with catalytic Cu(OTf)(2) were completed in <40 min. The results differed from those of the previous CuI-catalyzed reactions of tosylates in the presence of additives (LiOMe and TMEDA) for 12-24 h. It was shown that the preferred coordination of the leaving group to the reagents accelerated the reaction. Successful reagents were MeMgCl and other RMgX. Complete inversion was established. HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Shinohara, R; Morita, M; Ogawa, N; Kobayashi, Y or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. Recently I am researching about ESCHERICHIA-COLI; MICROCYSTIS-AERUGINOSA; ANTIFUNGAL ACTIVITY; RATIONAL DESIGN; DERIVATIVES; COMPONENT; ENZYME; GENES, Saw an article supported by the National Research and Development Plan [2017YFD0200506]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21877047, 21472062, 21877046, 21867011, 21472061, 31701820]; Project of the Science Fund of Jiangxi Education Office [GJJ170672]; Project of Hubei Natural Science Foundation [2017CFB232]; China postdoctoral science foundationChina Postdoctoral Science Foundation [2017M622486]; self-determined research funds of CCNU from the colleges’ basic research and operation of MOE [CCNU18ZDPY02]; Program of Introducing Talents of Discipline to Universities of China (111 program) [B17019]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Cyanobacterial pyruvate dehydrogenase multienzyme complex E1 (PDHc E1) is a potential target enzyme for finding inhibitors to control harmful cyanobacterial blooms. In this study, a series of novel triazole thiamin diphosphate (ThDP) analogs were designed and synthesized by modifying the substituent group of triazole ring and optimizing triazole-benzene linker as potential cyanobacterial PDHc E1 (Cy-PDHc E1) inhibitors. Their inhibitory activities against Cy-PDHc E1 in vitro and algicide activities in vivo were further examined. Most of these compounds exhibited prominent inhibitory activities against Cy-PDHc E1 (IC50 1.48-4.48 mu M) and good algicide activities against Synechocystis PCC6803 (EC50 0.84-2.44 mu M) and Microcystis aeruginosa FACHB905 (EC50 0.74-1.77 mu M). Especially, compound 8d showed not only the highest inhibitory activity against Cy-PDHc E1 (IC50 1.48 mu M), but also the most powerful inhibitory selectivity between Cy-PDHc E1 (inhibitory rate 98.90%) and porcine PDHc E1 (inhibitory rate only 9.54%). Furthermore, the potential interaction between compound 8d and Cy-PDHc E1 was analyzed by a molecular docking method and site-directed mutagenesis and enzymatic analysis and fluorescence spectral analysis. These results indicated that compound 8d could be used as a hit compound for further optimization and might have potential to be developed as a new algicide.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Fascio, ML; Sepulveda, CS; Damonte, EB; D’Accorso, NB in [Fascio, Mirta L.; D’Accorso, Norma B.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, Buenos Aires, DF, Argentina; [Damonte, Elsa B.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Buenos Aires, DF, Argentina; [Fascio, Mirta L.; D’Accorso, Norma B.] Univ Buenos Aires, CONICET, Ctr Invest Hidratos Carbono CIHIDECAR, Buenos Aires, DF, Argentina; [Sepulveda, Claudia S.; Damonte, Elsa B.] Univ Buenos Aires, CONICET, Inst Quim Biol, Fac Ciencias Exactas & Nat IQUIBICEN, Buenos Aires, DF, Argentina published Synthesis and antiviral activity of some imidazo[1,2-b] [1,3,4]thiadiazole carbohydrate derivatives in 2019.0, Cited 21.0. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Herein we describe the synthesis of imidazo [2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junin virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.

Recommanded Product: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Fascio, ML; Sepulveda, CS; Damonte, EB; D’Accorso, NB or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION, Saw an article supported by the DST of India [DST EMR/2015/000285]; UGC, IndiaUniversity Grants Commission, India; Indian Institute of Technology Delhi; DST-FISTDepartment of Science & Technology (India); IIT D. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dolui, P; Hazra, S; Deb, M; Elias, AJ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Synthesis of Diastereoenriched alpha-Aminomethyl Enaminones via a Bronsted Acid-Catalyzed Asymmetric aza-Baylis-Hillman Reaction of Chiral N-Phosphonyl Imines published in 2020, Reprint Addresses Li, GG (corresponding author), Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA.; Li, GG (corresponding author), Nanjing Univ, Sch Chem & Chem Engn, Inst Chem & BioMed Sci, Nanjing 210093, Peoples R China.; Jiang, B (corresponding author), Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

An effective chiral GAP methodology for preparing alpha-aminomethyl enaminones through a (R)-CSA-catalyzed asymmetric aza-Baylis-Hillman reaction is reported. Excellent yields and high diastereoselectivity could be obtained under mild conditions and convenient GAP techniques. The confirmations of the absolute configuration of N-phosphonyl imine and chiral enaminone by X-ray diffraction provides an explicit explanation of the chirality mechanism for GAP chemistry.

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Liu, YX; Ahmed, S; Qin, XY; Rouh, H; Wu, GZ; Li, GG; Jiang, B or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Isothiourea-Catalysed Regioselective Acylative Kinetic Resolution of Axially Chiral Biaryl Diols WOS:000459323700023 published article about ENANTIOSELECTIVE ACYL TRANSFER; ASYMMETRIC ESTERIFICATION; PIVALIC ANHYDRIDE; FACILE SYNTHESIS; DIPHENYLACETIC ACID; CARBOXYLIC-ACIDS; BASICITY SCALE; ALCOHOLS; SECONDARY; DERIVATIVES in [Qu, Shen; Greenhalgh, Mark D.; Smith, Andrew D.] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland in 2019.0, Cited 104.0. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

An operationally simple isothiourea-catalysed acylative kinetic resolution of unprotected 1,1 ‘-biaryl-2,2 ‘-diol derivatives has been developed to allow access to axially chiral compounds in highly enantioenriched form (s values up to 190). Investigation of the reaction scope and limitations provided three key observations: i) the diol motif of the substrate was essential for good conversion and high s values; ii) the use of an alpha,alpha-disubstituted mixed anhydride (2,2-diphenylacetic pivalic anhydride) was critical to minimize diacylation and give high selectivity; iii) the presence of substituents in the 3,3 ‘-positions of the diol hindered effective acylation. This final observation was exploited for the highly regioselective acylative kinetic resolution of unsymmetrical biaryl diol substrates bearing a single 3-substituent. Based on the key observations identified, acylation transition state models have been proposed to explain the atropselectivity of this kinetic resolution.

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Qu, S; Greenhalgh, MD; Smith, AD or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors published in 2020.0, Reprint Addresses Zhang, JJ (corresponding author), China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China.; Yang, Q (corresponding author), Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China.; Yang, Q (corresponding author), Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.

Recommanded Product: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CELECOXIB; DESIGN; APOPTOSIS; ACID; MICE, Saw an article supported by the Science and Technology Planning Program of Guangzhou [201704020146]; Science and Technology Planning Program of Guangdong Province [509164523031]. Application In Synthesis of 4-Nitrobenzoic acid. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the most effective derivative. Compound 11 chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound 11 caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochemical indicators (TNF-alpha, IL-10, SOD and MDA) in a rat MCAO model. The lethal dose (LD50) of compound 11 in mice receiving intraperitoneal injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and intravenous administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and intravenous administration, respectively). Based on these findings, compound 11 may be a promising neuroprotectant for the treatment of ischemic stroke. (C) 2020 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem