Tag: M.W:200-300

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is , belongs to phthalazines compound. In a document, author is Popovici, Lacramioara, Quality Control of (S)-2-(4-Aminobenzamido)pentanedioic acid.

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives

Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolo[1,2-b]pyridazine or a pyrrolo[2,1-a]phthalazine moiety was introduced in place of the 3 ‘-hydroxy-4 ‘-methoxyphenyl ring of phenstatin have been synthesised and their structure-activity relationship (SAR) was studied. Fourteen of the new compounds were evaluated for their in vitro cytotoxic activity by National Cancer Institute (NCI) against 60 human tumour cell lines panel. The best five compounds in terms of in vitro growth inhibition were screened in the second stage five dose-response studies, three of them showing a very good antiproliferative activity with GI(50)<100 nM on several cell lines including colon, ovarian, renal, prostate, brain and breast cancer, melanoma and leukemia. Docking experiments on the biologically active compounds showed a good compatibility with the colchicine binding site of tubulin. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4271-30-1, in my other articles. Quality Control of (S)-2-(4-Aminobenzamido)pentanedioic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1676-73-9, Name is H-Glu(OBzl)-OH, molecular formula is C12H15NO4. In an article, author is Aljaar, Nayyef,once mentioned of 1676-73-9, Name: H-Glu(OBzl)-OH.

Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines

The reaction of 2-(bromomethyl)benzaldehydes with arylhydrazines employing K2CO3 as a base and FeCl3 as a catalyst in CH3CN at 100 degrees C delivers 2-aryl-1,2-dihydrophthalazines with yields ranging from 60 to 91%. The transformation is considered to proceed as an intermolecular condensation/intramolecular nucleophilic substitution.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5. In an article, author is Machura, B.,once mentioned of 4474-86-6, COA of Formula: C12H14N2O5.

Syntheses, structures, thermal and luminescent properties of cadmium(II) complexes based on quinazoline and phthalazine

Six cadmium(II) compounds [Cd(Qnz)(2)(SCN)(2)](n) (1), [Cd(Qnz)(2)(dca)(2)](n) (2), [Cd(Qnz)(2)(N-3)(2)]}(n) (3), [Cd-2(mu-SCN-kappa N-2:S)(2)(SCN)(2)(Ptz)(4)(H2O)(2)] (4), [Cd(Ptz)(2)(dca)(2)](n) (5) and [Cd(Ptz)(MeOH)(N-3)(2)](n) (6) were successfully synthesized and characterized by single-crystal diffraction. Additionally, the samples were characterized by powder X-ray diffraction (PXRD), thermal analysis and IR spectroscopy. The fluorescence properties of 1, 2, 3, 5 and 6 were studied in solid state, while emission spectrum of 4 was recorded in methanolic solution. All they were compared with the fluorescence properties of the free ligands. Additionally, the electronic spectrum of 4 was investigated at the TDDFT level employing B3LYP functional in combination with LANL2DZ. (C) 2013 Elsevier Ltd. All rights reserved.

Interested yet? Keep reading other articles of 4474-86-6, you can contact me at any time and look forward to more communication. COA of Formula: C12H14N2O5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 4474-86-6, 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5, belongs to phthalazines compound. In a document, author is Atar, Amol B., introduce the new discover.

beta-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with beta-cyclodextrine-SO3H as a recyclable catalyst for the first time. [GRAPHICS] .

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4474-86-6. SDS of cas: 4474-86-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, SDS of cas: 622-88-8, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, molecular formula is C6H8BrClN2, belongs to phthalazines compound. In a document, author is Berber, Nurcan.

Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 622-88-8, in my other articles. SDS of cas: 622-88-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Zinczenko, Wiktoria, once mentioned the application of 886-86-2, Product Details of 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is C10H15NO5S, molecular weight is 261.29, MDL number is MFCD00013176, category is phthalazines. Now introduce a scientific discovery about this category.

Azines and Azoloazines, Part 1: Reactions of Triazolo[3,4-a]phthalazine and Its Derivatives with Carbanions

Triazolo[3,4-a]phthalazine as well as their chloro and nitro derivatives were subjected to the reactions with the carbanions typical for the vicarious nucleophilic substitution (VNS) of hydrogen. The reactions were strongly dependent on the substituents present on the triazolo[3,4-a]phthalazine ring and resulted not only in the substitution of hydrogen but also in exchange of chlorine atom and pyridazine ring scission; the latter process dominated for the unsubstituted triazolophthalazine. Two of the products showed promising stimulating activity towards the central nervous system with no significant toxic effects.

If you are interested in 886-86-2, you can contact me at any time and look forward to more communication. Product Details of 886-86-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 102089-74-7, Name is Boc-D-Phenylglycinol, formurla is C13H19NO3. In a document, author is Seo, Dong Wan, introducing its new discovery. Application In Synthesis of Boc-D-Phenylglycinol.

Preparation and properties of phosphoric acid doped sulfonated poly(tetra phenyl phthalazine ether sulfone) copolymers for high temperature proton exchange membrane application

Phosphoric acid-doped sulfonated poly(tetra phenyl phthalazine ether sulfone) (PA-SPTPPES) copolymers were successfully synthesized by the 4,4′-dihydroxydiphenylsulfone with 1,2-bis(4-fluorobenzoyl)-3,4,5,6-tetraphenylbenzene (BFBTPB) and 4,4′-difluorodiphenylsulfone in sulfolane. Poly(tetra phenyl phthalazine ether sulfone)s (PTPPESs) were prepared via an intramolecular ring-closure reaction of dibenzoylbenzene of precursor and hydrazine. The sulfonated poly(tetra phenyl phthalazine ether sulfone) (SPTPPES) membranes were obtained by sulfonation under concentrated sulfuric acid, and followed phosphoric acid-doped by immersion in phosphoric acid. Different contents of doped and sulfonated unit of PA-SPTPPES (10, 15, 20 mol% of BFBTPB) were studied by FT-IR, H-1 NMR spectroscopy, and thermo gravimetric analysis (TGA). The ion exchange capacity (IEC) and proton conductivity of SPTPPESs and PA-SPTPPESs were evaluated with increase of degree of sulfonation and doping level. The PA-SPTPPESs membranes exhibit proton conductivities (80 degrees C, relative humidity 30%) of 41.3 similar to 74.1 mS/cm and the maximum power densities of PA-SPTPPES 10, 15, and 20 were about 294, 350, and 403 mW/cm(2). Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 102089-74-7 help many people in the next few years. Application In Synthesis of Boc-D-Phenylglycinol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 80382-23-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazines compound. In a article, author is Ghahremani, Mahboubeh, introduce new discover of the category.

Synthesis of phthalazine compounds using heterogeneous base catalyst based on silica nanoparticles obtained from rice husk

In this study, the nanoparticles of amorphous silica were easily extracted from low-cost rice husk ash. They were functionalized with 3-(chloropropyl) trimethoxysilane by incorporating chloropropyl groups directly through the condensation of nanosilica and 3-chloropropyl trimethoxysilane. The target composite was synthesized by nucleophilic substitution of 1,4-diazabicyclo[2.2.2]octane (DABCO) onto the propyl groups. The effective required extent of this nanocomposite for the preparation of phthalazine-trione and phthalazine-dione derivatives is surprising under reflux conditions via the one-pot three-component condensation reaction of phthalhydrazide, aromatic aldehydes, and diketones. This green catalyst is easily recovered and re-utilized for the next reaction at least four runs without having any considerable influence on the yields. This simple green methodology not only improves the purity of the product, but also provides environmental and economic advantages. Furthermore, H-1 and C-13 chemical shift values, X-ray spectra, and the structural characteristics of phthalazine-dione compounds have been investigated in detail. The obtained values from DFT calculations including chemical shifts and structural parameters were compared with the corresponding experimental data. The calculated H-1 and C-13 chemical shifts and X-ray spectra are in good agreement with experimental ones.

Synthetic Route of 80382-23-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 80382-23-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 402-49-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazines compound. In a article, author is Kidwai, Mazaahir, introduce new discover of the category.

A Rapid and an Efficient Route to the One-pot, Multicomponent Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Ring Systems

CAN is found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via one-pot coupling reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in PEG as solvent. The major attributes of this synthetic protocol are the use of nontoxic, inexpensive, and readily available catalyst, mild conditions, easy work up, improved yields, and the PEG 400 as solvent that is environmentally benign as well as recyclable.

Reference of 402-49-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 402-49-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Fandzloch, Marzena, once mentioned the application of 608141-42-0, Safety of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, molecular weight is 273.3486, MDL number is MFCD22677268, category is phthalazines. Now introduce a scientific discovery about this category.

Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi

Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cisfactRuCl(2)(clinso)(3)(tmtP)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]center dot 2H(2)O (2) and fac,cis-[RuCl3(H2O)(tmtp)(2)] (3). Their structures were characterized using X-ray and spectroscopic methods (IR, NMR or EPR). The stability of the synthesized complexes 1-3 in various buffered solutions (pH = 3-7.4) was monitored using conventional and stopped-flow techniques. The in vitro antiproliferative activity of all ruthenium complexes against promastigote forms of Leishmania spp. (L. infarztum, L. braziliensis, and L. donovani) and epimastigote forms of Trypanosoma cruzi was investigated. Notably, the results showed that the activity of 1 against L. brasiliensis was more than three-fold higher than that of glucantime, and 1 showed no appreciable toxicity towards J774.2 macrophages. Additionally, 2 displayed even 141-fold lower toxicity against host cells than glucantime, demonstrating significantly higher selectivity than the reference drug. Therefore, 1 and 2 appear to be excellent candidates for further development as potential drugs for the effective treatment of leishmaniasis and Chagas disease. All novel complexes were also shown to be potent inhibitors of Fe-SOD in the studied species, while their effects on human CuZn-SOD were very low.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem