Tag: M.W:200-300

Electric Literature of 108-36-1, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 108-36-1, Name is 1,3-Dibromobenzene, SMILES is BrC1=CC(Br)=CC=C1, belongs to phthalazines compound. In a article, author is El-Faham, Ayman, introduce new discover of the category.

Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride-ethanol (1/1), C15H17ClN4OS

C15H17ClN4OS, triclinic, P1 (no. 2), a = 7.5069(2) angstrom, b = 9.4329(3)angstrom, c = 11.9723(4)angstrom, beta = 81.6963(11)degrees, gamma = 78.2307(9)degrees, g = 86.700(1)degrees, V = 820.91(4) angstrom(3), Z = 2, R-gt(F) = 0.0621, wR(ref)(F-2) = 0.1923, T = 100 K.

Electric Literature of 108-36-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 108-36-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yu, Hai-Ling, once mentioned the application of 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N, molecular weight is 207.2704, MDL number is MFCD00799420, category is phthalazines. Now introduce a scientific discovery about this category, Application In Synthesis of 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile.

Effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine on Anticoagulation in Mice and the Inhibition of Experimental Thrombosis in Rats

Thrombosis is a major complication that could be fatal in acute or chronic cardio-cerebral-vascular diseases. Therefore, the development of novel agents for anticlotting and the prevention of thrombosis and cardiovascular diseases are clinically significant. This study aimed to evaluate the anticoagulant and antithrombotic effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine (Q808), a new phthalazine tetrazole derivative. Bleeding time, clotting time, and serum calcium ion (Ca2+) concentration were assessed in mice, whereas arteriovenous thrombus weight and plasma prothrombin time were evaluated in rats, and platelets Ca2+ influx was determined in rabbit. Daily oral administration of Q808 at 25, 50, or 100 mg/kg for 3 days significantly delayed bleeding time and clotting time in mice compared with controls. Q808 administration at 50 mg/kg significantly reduced experimental thrombus weight by 62.6% and delayed plasma prothrombin time by 58.7% in rats, whereas 50 and 100 mg/kg of Q808 daily significantly increased serum Ca2+ concentration in mice. Q808 at 0.2, 0.4, and 0.8 mg/mL significantly inhibited thrombin-induced Ca2+ influx in rabbit platelets. Our results suggest that Q808 at 25-200 mg/kg daily exerts anticoagulant and antithrombotic effects, and its mechanisms of action may involve both the intrinsic and extrinsic coagulation pathways that inhibit certain coagulation factors and platelet functions.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 1878-68-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, belongs to phthalazines compound. In a article, author is Wang, Yuxiang, introduce new discover of the category.

Cascade Oxidation/Halogenoaminocyclization Reaction of Trifluoromethylated Homoallylic N-Acylhydrazines: Metal-free Synthesis of CF3-Substituted Pyrazolines

An efficient and practical cascade oxidation/halogenoaminocyclization of trifluoromethylated homoallylic N-acylhydrazines is developed. The protocol enables an efficient access to various biologically interesting CF3-containing pyrazoline compounds from readily accessible trifluoromethylated homoallylic N-acylhydrazines in good to excellent yields under mild conditions without any other additives or catalysts. The produced pyrazoline compounds can be further manipulated to other more complicated derivatives through transformation of residual halogen atom.

Application of 1878-68-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1878-68-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, molecular formula is C6H10ClN3O2S. In an article, author is El-Shamy, Ibrahim E.,once mentioned of 17852-52-7, Category: phthalazines.

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

1-Chloro-4-(2,4,6-trimethylphenyl) phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using H-1 NMR, C-13 NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Interested yet? Keep reading other articles of 17852-52-7, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, molecular formula is C13H13NO2S2. In an article, author is Pouramiri, Behjat,once mentioned of 201611-92-9.

One-pot, four-component synthesis of new 3,4,7,8-tetrahydro-3,3-dimethyl-11-aryl-2H-pyridazino[1,2-a]indazole-1,6,9(11H)-triones and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using an acidic ionic liquid N,N-diethyl-N-sulfoethanammonium chloride ([Et3N-SO3H]Cl) as a highly efficient and recyclable catalyst

A rapid and efficient one-pot, four-component protocol for the synthesis of novel 2H-pyridazino[1,2-a]indazole-1,6,9(11H)-triones (6) and 2H-indazolo[2,1-b]phthalazine-1,6,11-triones (7) has been developed using a stable and reusable Bronsted acidic ionic liquid N,N-diethyl-N-sulfoethanammonium chloride ([Et3N-SO3H]Cl). A range of diverse aldehydes were successfully applied and the corresponding products obtained in good to excellent yields without any by-products. (C) 2016 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7524-50-7, Name is H-Phe-OMe.HCl, molecular formula is C10H14ClNO2. In an article, author is Yu, Li-Jun,once mentioned of 7524-50-7, HPLC of Formula: C10H14ClNO2.

Was Compound BM-1 Worth for Further Research and Development?

In a previous research, we found a compound named 6-(3-(trifluoromethyl)-benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (BM-1) much more effective in the maximal electroshock (MES) model for mouse and much safer in the neurotoxicity (NT) screening, which indicated that it may be used as antiepileptic drug. But, those evaluations were too rough. So in this study, we did more work to assess the anticonvulsant activity and the toxicity about BM-1. The peak times of protection of BM-1 after intraperitoneal injection (ip) and oral administration (po) were determined using the MES test, and the anticonvulsant activity of it was compared with the reference drug, carbamazepine, at these peak times. The rotarod test was applied to measure its neurotoxicity. When compared with the reference drug in the maximal electroshock (MES) test at the time to peak effect, it showed that BM-1 was much more effective and safer than reference drug Carbamazepine with ED50 of 11.2 mg/kg, TD50 of 72.2 mg/kg and PI of 6.5 after administration of ip, while when administered orally, that values of ED50, TD50 and PI of BM-1-1, BM-1-2 and BM-1-3 were much better than Carbamazepine and BM-1 after po. The compound BM-1 has more effective anticonvulsant activity and lower neurotoxicity administered by both ip and po. So BM-1 could may be used instead of the prescribed antiepileptic drugs (AEDs) in the future.

Interested yet? Keep reading other articles of 7524-50-7, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H14ClNO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, begins with the direct observation of nature¡ª in this case, of matter.402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazines compound. In a document, author is Carbonell, E., introduce the new discover.

Acid-base behaviour and binding to double stranded DNA/RNA of benzo[g]phthalazine-based ligands

The affinity and the binding mode of two benzo[g]phthalazine compounds, functionalized with one or two 2-(imidazole-4-yl)-ethylamine groups, to DNA and RNA models have been evaluated by means of UV-Vis, fluorescence and circular dichroism (CD) spectroscopies in combination with viscometry and molecular dynamics. Both organic molecules bind strongly to all nucleic acid models via the intercalation mode in the duplex structure, especially compound 1. Intriguingly, 1 exhibits different emission responses depending on the base composition of duplex DNA/RNAs, which points out the possibility of using it as a base selective nucleic acid probe. Moreover, the acid-base behaviour of both compounds has been studied by pH-metric titrations and UV-Vis and emission fluorescence techniques to investigate the unexplored basicity of this type of compound. 1 behaves as a triprotic base whilst 2 is a diprotic base with the protonation of the benzo[g]phthalazine moiety occurring in the physiological pH range.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 402-49-3. Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 618-88-2, Name is 5-Nitroisophthalic acid. In a document, author is Lavrenova, L. G., introducing its new discovery. Formula: C8H5NO6.

Mono- and heteroligand iron(II) complexes with tris(3,5-dimethylpyrazol-1-yl)methane

Coordination compounds of iron(II) thiocyanate with tris(3,5-dimethylpyrazol-1-yl)methane (HC(3,5-Me(2)Pz)(3)), [Fe(HC(3,5-Me(2)Pz)(3))(2)](NCS)(2)] (I) and [Fe(HC(3,5-Me(2)Pz)(3))(D hz)(NCS)(2)] center dot H2O (II), where D hz is phthalazine, are synthesized. The complexes are studied by X-ray diffraction analysis, diffuse reflectance and IR spectroscopy, and static magnetic susceptibility measurements. The single crystals are obtained, and the molecular and crystal structures of complex II and compounds [Fe(HC(3,5-Me(2)Pz)(3))(3,5-Me(2)Pz)(NCS)(2)] center dot D2H5OH (III), where 3,5-Me(2)Pz is 3,5-dimethylpyrazole, and [Fe(HC(3,5-Me(2)Pz)(3))(2)][Fe(HC(3,5-Me(2)Pz)(3))(NCS)(3)](2) (IV) are determined (CIF files CCDC 1415452 (II), 1415453 (III), and 1415454 (IV)). The study of the temperature dependence mu(eff)(D cent) in a range of 2-300 K shows exchange interactions of the antiferromagnetic character between the iron(II) ions in complexes I and II.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 618-88-2 help many people in the next few years. Formula: C8H5NO6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1878-68-8, Name is 4-Bromophenylacetic acid, molecular formula is C8H7BrO2. In an article, author is Fandzloch, Marzena,once mentioned of 1878-68-8, COA of Formula: C8H7BrO2.

Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi

Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cisfactRuCl(2)(clinso)(3)(tmtP)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]center dot 2H(2)O (2) and fac,cis-[RuCl3(H2O)(tmtp)(2)] (3). Their structures were characterized using X-ray and spectroscopic methods (IR, NMR or EPR). The stability of the synthesized complexes 1-3 in various buffered solutions (pH = 3-7.4) was monitored using conventional and stopped-flow techniques. The in vitro antiproliferative activity of all ruthenium complexes against promastigote forms of Leishmania spp. (L. infarztum, L. braziliensis, and L. donovani) and epimastigote forms of Trypanosoma cruzi was investigated. Notably, the results showed that the activity of 1 against L. brasiliensis was more than three-fold higher than that of glucantime, and 1 showed no appreciable toxicity towards J774.2 macrophages. Additionally, 2 displayed even 141-fold lower toxicity against host cells than glucantime, demonstrating significantly higher selectivity than the reference drug. Therefore, 1 and 2 appear to be excellent candidates for further development as potential drugs for the effective treatment of leishmaniasis and Chagas disease. All novel complexes were also shown to be potent inhibitors of Fe-SOD in the studied species, while their effects on human CuZn-SOD were very low.

Interested yet? Keep reading other articles of 1878-68-8, you can contact me at any time and look forward to more communication. COA of Formula: C8H7BrO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 102089-74-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 102089-74-7, Name is Boc-D-Phenylglycinol, SMILES is [C@@H](NC(OC(C)(C)C)=O)(C1=CC=CC=C1)CO, belongs to phthalazines compound. In a article, author is Khalili, Akram, introduce new discover of the category.

Synthesis and characterization of 4-methyl-1-(3-sulfopropyl)pyridinium hydrogen sulfate as a new ionic liquid immobilized on silica nanoparticles: A recyclable nanocomposite ionic liquid for the production of various substituted phthalazine-ones

4-Methyl-1-(3-sulfopropyl)pyridinium hydrogen sulfate ([MSPP][HSO4]) as a new acidic ionic liquid was prepared in a quick and easy process, and characterized by some techniques such as H-1 NMR, C-13 NMR and FT-IR analysis. Then, [MSPP][HSO4] was immobilized on silica nanoparticles by impregnation method to afforded heterogeneous acidic ionic liquid ([MSPP]HSO4@nSiO(2)) and characterized by elemental analysis (CHNS), FT-IR, and SEM. The worthiness of [MSPP]HSO4@nSiO(2) has been investigated for the synthesis of various substituted phthalazine-ones as well as selective synthesis of mono- and bis-phthalazine-ones as imperative biologically active compounds. The reaction has been carried out under solvent-free conditions, simple work-up procedure and the products were obtained in excellent to good yields. Moreover, the catalyst was reused five times without decay in catalytic activity performance. (C) 2018 Elsevier B.V. All rights reserved.

Application of 102089-74-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 102089-74-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem