Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. HPLC of Formula: C12H14O3, 93-28-7, Name is Eugenol Acetate, SMILES is CC(OC1=CC=C(CC=C)C=C1OC)=O, in an article , author is Lamera, Esma, once mentioned of 93-28-7.

Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1H-indazolo[1,2-b] phthalazine-1,6,11-trione

The title compound, C21H16N2O3, consists of an indazolone moiety, bearing a phenyl group, fused to a phthalazine ring system (r. m. s. deviation = 0.018 angstrom). The phenyl ring is almost normal to the mean plane of the five-membered ring of the indazolone moiety, making a dihedral angle of 89.64 (7)degrees. The six-membered ring of the indazolone moiety has an envelope conformation, with the central methylene C atom as the flap. In the crystal, molecules are linked via C-H center dot center dot center dot O hydrogen bonds, forming slabs parallel to the bc plane. The slabs are linked via C-H center dot center dot center dot pi and pi-pi interactions [the shortest intercentroid distance involving rings of pyrazolophthalazine moieties is 3.6430 (8) angstrom], forming a three-dimensional structure.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 93-28-7, you can contact me at any time and look forward to more communication. HPLC of Formula: C12H14O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

618-88-2, Name is 5-Nitroisophthalic acid, molecular formula is C8H5NO6, belongs to phthalazines compound, is a common compound. In a patnet, author is Sen, Supriti, once mentioned the new application about 618-88-2, Recommanded Product: 5-Nitroisophthalic acid.

EFFICIENT AND CONVENIENT METHODS FOR SYNTHESIS OF SOME PHTHALAZINE DERIVATIVES AND THEIR EVALUATION OF CYTOTOXICITY

A systematic study of the reaction of 1,4-dihydrazinophthalazine (DHPH) with 1,3-dicarbonyls [viz., acetylacetone (acac), dibenzoylmethane (bzbz), and 1-benzoylacetone (bzac)] varying the reaction conditions was carried out to obtain the phthalazine derivatives (1-4). One-pot reaction of DHPH with acac led to the formation of two compounds 1 and 2, with various factors such as the presence of the acid or base, amount of the acac, time of reflux, and the temperature. The reaction conditions of DHPH with bzbz or bzac are sort of different to isolate the products 3 and 4, respectively. The derivatives (1-4) have been characterized by elemental analyses, H-1 NMR, and electrospray ionization-mass spectrometry (ESIMS) and the cytotoxic activity of the compounds 1-4 was evaluated on HeLa cell line. [Supplementary materials are available for this article. Go to the publisher’s online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 618-88-2. The above is the message from the blog manager. Recommanded Product: 5-Nitroisophthalic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Safety of N-Cbz-D-Asparagine, 4474-86-6, Name is N-Cbz-D-Asparagine, SMILES is O=C(N)C[C@H](C(O)=O)NC(OCC1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is Shaterian, Hamid Reza, introduce the new discover.

Mild basic ionic liquids catalyzed new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

A new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using three weak basic ionic liquids such as 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate, pyrrolidinium formate, and pyrrolidinium acetate as efficient catalysts for condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes under ambient and solvent-free conditions in excellent yields is described. (C) 2012 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4474-86-6 is helpful to your research. Safety of N-Cbz-D-Asparagine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, COA of Formula: C7H5BrFNO2, begins with the direct observation of nature¡ª in this case, of matter.502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazines compound. In a document, author is Veisi, Hojat, introduce the new discover.

Protic ionic liquid [TMG][Ac] as an efficient, homogeneous and recyclable catalyst for one-pot four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones and dihydro-1H-pyrano[2,3-c]pyrazol-6-ones

The mildly basic ionic liquid N,N,N,N-tetramethylguanidinium acetate [TMG][Ac] was found to be a very effective basic catalyst for the one-pot, four-component synthesis of 2H-indazolo[2,1-b] phthalazinetriones by condensation of phthalic anhydride, hydrazinium hydroxide, aromatic aldehydes, and dimedone in high yields at 80 degrees C. [TMG][Ac] catalyzed simple and efficient one-pot four-component reaction of Meldrums acid, ethyl acetoacetate, hydrazine hydrate, and aromatic aldehydes to give dihydro-1H-pyrano[2,3-c] pyrazol-6-ones is reported. The ionic liquid could be recycled several times without loss of efficiency with regards to the reaction times and yields.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 502496-34-6. COA of Formula: C7H5BrFNO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 2215-77-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2215-77-2, Name is 4-Phenoxybenzoic acid, SMILES is OC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1, belongs to phthalazines compound. In a article, author is Mozafari, Roya, introduce new discover of the category.

Phosphotungstic acid supported on SiO2@NHPhNH2 functionalized nanoparticles of MnFe2O4 as a recyclable catalyst for the preparation of tetrahydrobenzo[b]pyran and indazolo[2,1-b]phthalazine-triones

MnFe2O4@SiO2@NHPhNH2-phosphotungstic acid was synthesized by the reaction of diamine-modified silica coated manganese ferrite nanoparticles with H3PW12O40, the Keggin-type heteropoly acid. This is the first time that H3PW12O40 supported on diamine functionalized MnFe2O4 nanoparticles has been reported. The synthesized catalyst was characterized by various techniques, including Fourier Transform Infrared Spectroscopy (FTIR), Transmission electron-microscopy (TEM), X-ray Powder Diffraction (XRD), Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), Thermogravimetric Analysis (TGA), and Vibrating Sample Magnetometer (VSM). The synthesized nanoparticle was examined as the heterogenous nanocatalyst for the synthesis of tetrahydrobenzo[b]-pyran derivatives and 2H-indazolo-[2,1-b]-phthalazine-triones under the solvent-free heating or ultrasonic irradiation conditions. This method offers several advantages including high yield, low reaction times, and the simple work up procedure due to the presence of the magnetic nanoparticles in this catalyst, so that, it can be easily recovered and reused for at least six successive times without the loss of its high catalytic activity, suggesting its great Potential for industrial applications. (C) 2019 Elsevier Ltd. All rights reserved.

Related Products of 2215-77-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, in an article , author is Maheswari, Cinnathambi Subramani, once mentioned of 81-16-3, Recommanded Product: 81-16-3.

Antibacterial Evaluation of Some 3-Amino-1H-Pyrazolo[1,2-b]Phthalazine-2-Carboxamides by using Fish Scale Hydroxyapatite as a Heterogeneous Catalyst

Fish scale hydroxyapatite (FS-HAP) has been used as an efficient catalyst for the synthesis of 3-amino-1H-pyrazolo[1,2-b]phthalazine-2-carboxamide derivatives via the one-pot, three-component cyclocondensation reactions of aromatic aldehydes with cyanoacetamide and phthalhydrazide under solvent-free condition. FS-HAP has been characterized by FT-IR, XRD, SEM and EDS techniques. The synthesized compounds were evaluated for their in vitro antibacterial activity against gram-positive (Bacillus cereus, Bacillus aryabhattai, Bacillus megaterium, Staphylococcus aureus) and gram-negative (Serratia marcescens, Bacillus Pseudomonas putida, Escherichia coli, Enterobacter cloacae) bacteria. Tetracycline and erythromycin were used as standard antibiotics in this investigation. In the present protocol, we have achieved remarkable yields of the product in shorter reaction time and the catalyst was easily recovered and reused.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 81-16-3, you can contact me at any time and look forward to more communication. Recommanded Product: 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], belongs to phthalazines compound. In a document, author is Ayala, Gerardo, introduce the new discover, Safety of Sodium 2-formylbenzenesulfonate.

Copper(I) thiocyanate networks with aromatic diimine ligands

A total of five new CuSCN-LL complexes with aromatic diimine ligands, LL = quinoxaline (Qox), quinazoline (Qnz), phthalazine (Ptz), 2-aminopyrazine (2-NH(2)Pyz), and 2-methoxypyrazine (2-MeOPyz) have been prepared and characterized by crystallographic methods. The following compounds are reported: (CuSCN)(2)(Qox) (1), (CuSCN)(Qnz) (2), (CuSCN)(2)(Ptz) (3), (CuSCN)(2)(2-NH2Pyz) (4), and (CuSCN)(2-MeOPyz) (5). Compounds 1-4 were prepared using an extended aqueous reflux method in the presence of KSCN and ammonia. Compound 5 was prepared by directly reacting solid CuSCN with the liquid ligand. In complexes 2 and 5, LL is monodentate, while in others LL is bridging bidentate. All network structures are 2-D sheets, consisting of mu(2)-LL-crosslinked CuSCN ladders for 1 and 4, LL-decorated CuSCN sheets for 2 and 5, and unusual mu(2)-LL-stapled sheets for 3. (C) 2016 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1008-72-6 is helpful to your research. Safety of Sodium 2-formylbenzenesulfonate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn, HPLC of Formula: C13H17NO4, Especially from a beginner¡¯s point of view. Like 1149-26-4, Name is Z-L-Val-OH, molecular formula is C7H13NO2, belongs to esters-buliding-blocks compound. In a document, author is Khaleghi Abbasabadi, Masoud, introducing its new discovery.

beta-Alanine-functionalized magnetic graphene oxide quantum dots: an efficient and recyclable heterogeneous basic catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 2,3-dihydroquinazolin-4(1H)-one derivatives

In this research, we report a novel synthesis of magnetic beta-alanine-functionalized-graphene oxide quantum dots Fe3O4@GOQDs-N-(beta-alanine) as a recyclable and eco-friendly heterogeneous nanocatalyst. The catalytic efficiency of these nanosheets was explored as a basic catalyst for a one-pot three-component synthesis of various 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 2,3-dihydroquinazolin-4(1H)-one derivatives. The reactions proceeded smoothly under mild and green conditions to afford the respected products in excellent yields. The structure of this newly fabricated catalyst was successfully confirmed by different analytical techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, field emission-scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, and thermogravimetric analysis. The stability and recyclability of the catalyst were examined by performing the model reaction in six consecutive runs. The recovered catalyst from the first run was directly used for the next runs with no significant loss of catalytic activity.

If you are hungry for even more, make sure to check my other article about 1149-26-4, HPLC of Formula: C13H17NO4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of Ethyl 3-aminobenzoate methanesulfonate, 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, SMILES is O=C(OCC)C1=CC=CC(N)=C1.CS(=O)(O)=O, belongs to phthalazines compound. In a document, author is Thiel, Oliver R., introduce the new discover.

Process Research and Development for Heterocyclic p38 MAP Kinase Inhibitors

The need to access different heterocyclic cores as part of p38 MAP kinase inhibitors led to the discovery and development of several efficient approaches to three separate classes of heterocycles, namely phthalazines, pyrazolopyridinones, and triazolopyridines. This account summarizes our studies in this field in a comprehensive fashion. 1 Introduction 2 Synthesis of Phthalazine-Based p38 Inhibitors 2.1 Synthesis of Clinical Candidate 2 2.2 Synthesis of Clinical Candidate 3 3 Synthesis of Pyrazolopyridinone-Based p38 Inhibitors 4 Synthesis of Triazolopyridine-Based p38 Inhibitors 4.1 Synthesis through Pd-Catalyzed Benzhydrazide Couplings 4.2 Synthesis through Pd-Catalyzed Benzhydrazone Couplings 5.0 Conclusions

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 886-86-2. Quality Control of Ethyl 3-aminobenzoate methanesulfonate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Turkes, Cuneyt, once mentioned the application of 886-86-2, HPLC of Formula: C10H15NO5S, Name is Ethyl 3-aminobenzoate methanesulfonate, molecular formula is C10H15NO5S, molecular weight is 261.29, MDL number is MFCD00013176, category is phthalazines. Now introduce a scientific discovery about this category.

Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors

The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically preferential scaffolds, endowed with versatile pharmacological activity, such as anti-inflammatory, cardiotonic vasorelaxant, anticonvulsant, antihypertensive, antibacterial, anti-cancer action. The compounds were investigated for the inhibition against the cytosolic hCA I, II and AChE. Most screened sulfonamides showed high potency in inhibiting hCA II, widely involved in glaucoma, epilepsy, edema, and other pathologies (K(i)s in the ranging from 6.32 +/- 0.06 to 128.93 +/- 23.11 nM). hCA I was inhibited with K(i)s in the range of 6.80 +/- 0.10-85.91 +/- 7.57 nM, whereas AChE in the range of 60.79 +/- 3.51-249.55 +/- 7.89 nM. ADME prediction study of the designed N-substituted phthalazine sulfonamides showed that they are not only with carbonic anhydrase and acetylcholinesterase inhibitory activities but also with appropriate pharmacokinetic, physicochemical parameters and drug-likeness properties. Also, in silico docking studies were investigated the binding modes of selected compounds, to hCA I, II, and AChE.

Interested yet? Read on for other articles about 886-86-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H15NO5S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem