Tag: M.W:200-300

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazines compound. In a document, author is Taslimi, Parham, introduce the new discover, COA of Formula: C10H9NO3S.

Cholinesterases, alpha-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer’s disease and diabetes mellitus

In this study, using the Cu(OTf)(2) catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzymes with K-i values in the range of 4.88-15.94 nM for hCA I, 7.04-20.83 nM for hCA II, 68.25-158.27 for AChE, 60.17-91.27 for BChE and 0.36-2.36 nM for alpha-Gly, respectively. In silico studies were performed on the molecules inhibiting hCA I, hCA II, AChE, BChE and alpha-Gly receptors. When we evaluated the data obtained in this work, we determined the inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors. Reference inhibitors were used for all enzymes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. COA of Formula: C10H9NO3S.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 789-25-3, Name is Triphenylsilane, molecular formula is C18H16Si, belongs to phthalazines compound, is a common compound. In a patnet, author is Amin, Kamilia M., once mentioned the new application about 789-25-3, Safety of Triphenylsilane.

Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity

Efforts to develop new antitumor agents are now directed towards multitarget therapies that are believed to have high potency and low tendency to resistance compared to conventional drugs. Herein, we highlighted the synthesis and antitumor activity of five series of phthalazine-based compounds featuring a variety of bioactive chemical fragments at position 1 of the phthalazine nucleus. The antitumor activity of the target compounds was performed against fourteen cancer cell lines where all compounds were active in the nanomolar level. In addition, the mechanism of action of the target compounds was investigated through an enzymatic inhibitory assay against VEGFR-2 and EGFR kinases, revealing potent and preferential activity toward VEGFR-2. Binding mode of the most active compounds was studied using docking experiment. (C) 2016 Elsevier Masson SAS. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 789-25-3. The above is the message from the blog manager. Safety of Triphenylsilane.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 7507-86-0, Name is 2-Bromo-5-methoxybenzaldehyde, formurla is C8H7BrO2. In a document, author is Pouramiri, Behjat, introducing its new discovery. Product Details of 7507-86-0.

Acidic ionic liquids: highly efficient catalysts for one-pot four-component synthesis of pyrazolo [1,2-b] phthalazines under solvent-free conditions

A series of novel pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives has been synthesized via one-pot four-component reaction of aromatic aldehyde, ethyl or methyl acetoacetate, hydrazine hydrate, and phthalic anhydride in the presence of acidic ionic liquids such as 3-methyl-1-sulfo-1H-imidazol-3-ium chloride, 1,3-disulfo-1H-imidazol-3-ium chloride, and triethyl(sulfo)ammonium chloride as the catalyst. This method involves particular advantages such as environmentally benign catalysts, high yields of product, reusability of ionic liquids with high activity, short reaction times, no hazardous solvent, and easy workup.

If you are hungry for even more, make sure to check my other article about 7507-86-0, Product Details of 7507-86-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, belongs to phthalazines compound. In a document, author is Safaei-Ghomi, J., introduce the new discover, Formula: C8H7BrO2.

CuFe2O4 and ZrP2O7 nanoparticles as highly efficient catalysts for the one-pot synthesis of phthalazine derivatives under solvent-free conditions

ZrP2O7 and CuFe2O4 nanoparticles as efficient and reusable heterogeneous catalysts have been used for the preparation of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones, respectively, under solvent-free conditions in good to excellent yields and short reaction times. (C) 2016 Sharif University of Technology. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1878-68-8. Formula: C8H7BrO2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 886-86-2, Name is Ethyl 3-aminobenzoate methanesulfonate, SMILES is O=C(OCC)C1=CC=CC(N)=C1.CS(=O)(O)=O, belongs to phthalazines compound. In a document, author is Han, Yi, introduce the new discover, Product Details of 886-86-2.

Ag NPs on chitosan-alginate coated magnetite for synthesis of indazolo [2,1-b]phthalazines and human lung protective effects

Biocomposite nanomaterials have been evolved as the new generation catalysts and therapeutic supplement in these days. Magnetically isolation has added new features to this category. This has encouraged us to synthesize a novel Ag NP adorned chitosan-alginate dual bio-polysaccharide (two of the more versatile polysaccharides) modified core-shell magnetic nanocomposite (Fe3O4/CS-Alg/Ag NPs). The material was meticulously characterized following different physicochemical techniques, such as, FT-IR, ICP-OES, FESEM, EDX, atomic mapping, TEM, VSM, XRD and XPS studies. The as synthesized material was catalytically explored in the one-pot multicomponent synthesis of biologically potent 2H-indazolo[2,1-b]phthalazine-trione derivatives involving a wide range of substrates. The reactions were ended up with excellent yields under solvent-free heating conditions. The catalyst recyclability, heterogeneity and leaching tests were performed to ensure its high stability and robustness. It could be reused as much as 10 times in succession with almost unchanged catalytic performances. In the lung protective part of the present research, the human lung toxicity was induced by alpha-Guttiferin. The cell viability of lung MRC-5, CCD-19Lu, WI-38, and BEAS-2B cell lines was measured by trypan blue assay. Caspase-3 activity was assessed by the caspase activity colorimetric assay kit and mitochondrial membrane potential of lung cells was studied by Rhodamine123 fluorescence dye. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) test was used to show DNA fragmentation and apoptosis of lung cells. Also, the Rat inflammatory cytokine assay kit was used to measure the concentrations of inflammatory cytokines. The catalyst-treated cell cutlers significantly (p <= 0.01) reduced the DNA fragmentation, caspase-3 activity, and inflammatory cytokines concentrations, and raised the mitochondrial membrane potential and cell viability in the high concentration of alpha-Guttiferin-treated lung MRC-5, CCD-19Lu, WI-38, and BEAS-2B cells. The best result of lung protective properties of catalyst against alpha-Guttiferin was seen in the high dose of catalyst i.e., 4 mu g. DPPH test revealed similar antioxidant potentials for catalyst and butylated hydroxytoluene. The catalyst inhibited half of the DPPH molecules in the concentration of 171 mu g/mL. According to the above results, catalyst can be administrated as a lung protective drug for the treatment of lung diseases after approving in the clinical trial studies in humans. (C) 2020 Elsevier B.V. All rights reserved. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 886-86-2 is helpful to your research. Product Details of 886-86-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 81-16-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazines compound. In a article, author is Berber, Nurcan, introduce new discover of the category.

Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

Electric Literature of 81-16-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 81-16-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, molecular formula is C10H18N2O6S, belongs to phthalazines compound. In a document, author is Bakherad, Mohammad, introduce the new discover, Quality Control of 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate.

Synthesis of New Derivatives of 1,2,3-Triazole-Linked Phthalazine-1,4-dionein Water: Experimental Aspects and Molecular Docking Calculations

A new series of phthalazine-based 1,2,3-triazole derivatives are synthesized by the reaction of 2-methyl-3-(prop-2-yn-1-yl)-2,3dihydro- phthalazine-1,4-dione or 2,3-bis(prop-2-yn-1-yl)-2,3-dihydrophthalaz- ine-1,4-dione with aromatic azides via coppercatalyzed azide-alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high-to-excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their antibacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti-bacterial activity of the synthesized compounds was investigated using molecular docking calculations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 54381-16-7. Quality Control of 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 502496-34-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazines compound. In a article, author is Wang Wang, introduce new discover of the category.

An improved procedure for the three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using basic ionic liquid

An efficient and green method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been achieved through the one-pot, three-component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and phthalhydrazide in the presence of 1-butyl-3-methyl imidazolium hydroxide ([bmim]OH) as catalyst in EtOH. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid can be recovered and recycled for subsequent reactions. Moreover, this protocol has the advantages of easy work-up, short reaction time, mild reaction conditions and environmentally benign procedures compared with the reported methods.

Related Products of 502496-34-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 502496-34-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 7524-50-7, Name is H-Phe-OMe.HCl, SMILES is N[C@@H](CC1=CC=CC=C1)C(OC)=O.[H]Cl, in an article , author is Wang Chaojie, once mentioned of 7524-50-7, Quality Control of H-Phe-OMe.HCl.

Synthesis and Antitumor Activity Evaluation of 3,6-Substituted-1,2,4-triazolo[3,4-a]phthalazine Derivatives

With the aim of obtaining potential antitumor candidates with more efficiency and more economic value. A series of 3,6-substituted-1,2,4-triazolo[3,4-a]phthalazine derivatives were synthesized. The target products were obtained via cyclization, chlorination, substitution, cyclization, substituted with phthalic anhydride used as the starting material. The structures of target products are confirmed by H-1 NMR, C-13 NMR, HRMS. A series of 3,6-substituted-1,2,4-triazolo[3,4-a] phthalazine derivatives was evaluated for anticancer activity on four human cancer cell lines including EC-9706, HeLa and MCF-7 by MTT assay. Among them, compound 5d was more cytotoxic against EC-9706 and HeLa cell lines, with IC50 values ranging from 3.9 to 4.5 mu mol.L-1, which are superior or comparable to 5-Fuorouracil. Flow cytometry analysis indicated that compound 5d induced the cellular early apoptosis and cell cycle arrest in G2/M phase in EC-9706.

Interested yet? Read on for other articles about 7524-50-7, you can contact me at any time and look forward to more communication. Quality Control of H-Phe-OMe.HCl.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 83-53-4, Name is 1,4-Dibromonaphthalene, formurla is C10H6Br2. In a document, author is El-Shamy, Ibrahim E., introducing its new discovery. Computed Properties of C10H6Br2.

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxo-phthalazin-2yl] acetic acid hydrazide derivatives

The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16,19 in good yields. Furthermore, cc-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their corresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds. (C) 2014 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 83-53-4, Computed Properties of C10H6Br2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem