Tag: M.W:200-300

Reference of 53242-88-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 53242-88-9, molcular formula is C15H11ClN2O, introducing its new discovery.

PHTHALAZINONE DERIVATIVES

The use of a compound of the formula:and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of PARP, wherein: A and B together represent an optionally substituted. fused aromatic ring; Rc is represented by -L-RL, where L is of formula: -(CH2)N1-QN2-(CH2)N3- wherein n1, n2 and n3 are each selected from 0, 1, 2 and 3, the sum of n1, n2 and n3 is 1, 2 or 3 and Q is selected from O, S, NH or C(=O); and RL is an optionally 0 substituted C5-20 aryl group; and RN is selected from hydrogen, optionally substituted C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone. Novel compounds, and their use as pharmaceuticals, are also disclosed

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 53242-88-9 is helpful to your research. Reference of 53242-88-9

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N719 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 53242-88-9, name is 4-(4-Chlorobenzyl)phthalazin-1(2H)-one, introducing its new discovery. Formula: C15H11ClN2O

Aminocarboxylic acid derivatives having antiallergic/antiasthmatic effect and a process for their preparation

6-amino carboxylic acid derivatives having antiasthmatic and antiallergic properties which can be used for the preparation of medicaments. The compounds have the formula: STR1 wherein R1 and R2 represent hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms, benzyl or phenylethyl, R3 represents hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms or benzyl, X represents hydrogen, halogen, C1 -C6 -alkyl or C1 -C6 -alkoxy, Y1 and Y2 represent hydrogen, halogen, C1 -C6 -alkyl or C1 -C6 -alkoxy, where m, n and o can assume the values from 0-4.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 53242-88-9, and how the biochemistry of the body works.Formula: C15H11ClN2O

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N717 – PubChem

152265-57-1, Name is 7-Bromophthalazin-1(2H)-one, belongs to phthalazine compound, is a common compound. COA of Formula: C8H5BrN2OIn an article, once mentioned the new application about 152265-57-1.

Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8

The rhodium(III) catalyst tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate ([Cp*Rh(MeCN)3](SbF6)2) reacts with 1-(2H)-phthalazinones to promote a C-H functionalization event at C8. Preparation of a set of compounds arising from oxidative alkenylation with olefins, hydroarylation with alkynes, and iodination with N-iodosuccinimide is reported here. Oxidative alkenylation proceeds in very good yield, and the scope and limitations of the hydroarylation and halogenation reactions are discussed. Notably, this strategy enables rapid preparation of C8-substituted phthalazinones without requiring phthalazinone ring synthesis starting from a prefunctionalized arene.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 152265-57-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N712 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C8H5BrN2O, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 19064-73-4, Name is 4-Bromophthalazin-1(2H)-one, molecular formula is C8H5BrN2O

A […] ketone compound and its preparation method and application (by machine translation)

The invention discloses […] compounds, the compounds have the formula I structure: in the formula I: R is cyclopropyl, cyclopentyl, cyclohexyl, 4 N – methyl piperidinyl or 2, 2, 6, 6 – tetramethyl piperidine nitrogen-oxygen free radical; R ‘ is 1 – methyl – 1 H – pyrazolyl – 3, 1 – methyl – 1 H – pyrazole 3 – amino or 5 – methyl – 1 H – pyrazole 3 – amino; and its production method and application. The class of compounds HeLa human cervical carcinoma cells, human non-small cell lung cancer A549, human liver cancer cell HepG2, human colon cancer cell LoVo and HCT116 five cancer cell growth to have prominent inhibit function, can be used for preparing a pharmaceutical for the treatment of cancer, in particular in the preparation for treating cervical cancer, lung cancer, liver cancer and colon cancer of the application of the medicament. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C8H5BrN2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 19064-73-4, in my other articles.

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N695 – PubChem

Related Products of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

A phthalazinone derivative and its preparation method and medical use (by machine translation)

The present invention provides a phthalazinone derivative and its preparation method and medical use. In order to O-aldehyde benzoic acid as the raw material, by reaction with methyl (3 – oxo – 1, 3 – ISO-benzofuran – 1 – yl) phosphonic acid dimethyl ester, the compound with 3 – cyano – 4 – fluorophenyl with formaldehyde in the presence of triethylamine to produce (Z, E) – 2 – fluoro – 5 – [(3 – oxoisoindoline benzofuran – 1 (3 H) – ylidene) methyl] benzonitrile, it is hydrazine hydrate is reduced to 2 – fluoro – 5 – [(4 – oxo – 3, 4 – […] – 1 – yl) methyl] benzoic acid; benzene formaldehyde or substituted aryl formaldehyde or furfural as raw materials, with malonic acid in the Knoevenagel reaction, the obtained acrylic acid or substituted the acrylic acid or furan – 2 – acrylic acid, with 1 – tert-butoxycarbonyl piperazine generating amide reaction, the product in the presence of trifluoroacetic acid takes off uncle butoxycarbonyl, the obtained product with 2 – fluoro – 5 – [(4 – oxo – 3, 4 – […] – 1 – yl) methyl] benzoic acid generating amide reaction, to obtain a series of (E)- 4 – {3 – [4 – [(3 – substituted aromatic) acryloyl] piperazine – 1 – carbonyl] – 4 – fluorobenzyl} – 2 H – phthalazine – 1 – one derivatives. The initial pharmacological activity screening results show, the invention of the general formula of the compounds have certain in vitro PARP – 1 inhibition ability and the in vitro anti-tumor cell proliferation activity. The said compound of general structure is as follows: In the above formula: Ar selected from or R1 , R2 , R3 , R3 , R4 , R5 Can be a hydrogen atom, a fluorine atom, chlorine atom, bromine atom, methyl, methoxy, trifluoromethyl, nitro. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N754 – PubChem

Reference of 70724-23-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 70724-23-1, 1-Chloro-6,7-dimethoxyphthalazine, introducing its new discovery.

Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines

1-(3- or 4-substituted piperidino)phthalazines of the formula wherein R is C1-6 alkyl; Y is a 3- or 4-position substituent and is -X-(CHR1)m-Z wherein R1 is hydrogen or C1-6 alkyl; m is 1 or 2; X is oxygen or a direct link provided that when m is 1, X is a direct link; and Z is -N(R2)COR3, -N(R2)COOR3, -N(R2)SO2R3, -N(R2)SO2NR4R5, -N(R2)SOR3, -N(R2)CONR4R5 or -OCONR4R5, wherein R2 and R5 are each independently hydrogen or C1-6 alkyl; R3 is C1-6 alkyl, phenethyl, benzyl, C3-7 cycloalkyl, phenyl or pyridyl; R4 is hydrogen or R3; provided that when X is a direct link, R3 or R4 is C3-7 cycloalkyl; the pharmaceutically acceptable acid addition salts thereof; processes for their preparation; and their use as cardiac stimulants and phosphodiesterase inhibitors

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 70724-23-1. In my other articles, you can also check out more blogs about 70724-23-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N692 – PubChem

Synthetic Route of 53242-88-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53242-88-9, Name is 4-(4-Chlorobenzyl)phthalazin-1(2H)-one, molecular formula is C15H11ClN2O. In a Article£¬once mentioned of 53242-88-9

Synthesis of 2-Fluoroalkyl 4-Substituted Azepanes

Synthesis of di- and tri-substituted fluoroalkylated azepanes was achieved by ring expansion of pyrrolidines via a regioselective attack of nucleophiles on a bicyclic azetidinium intermediate. A broad scope of azepanes, substituted at C4 and bearing a alpha-trifluoromethyl, alpha-difluoromethyl or alpha-perfluorobutyl group, can be synthesized by this method by using a wide variety of nucleophiles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 53242-88-9. In my other articles, you can also check out more blogs about 53242-88-9

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N728 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery. Computed Properties of C16H11FN2O3

DUAL INHIBITORS OF PARP1 AND CDK

Disclosed herein, in various embodiments, are compounds having dual activity as PARP1 and CDK inhibitors, and pharmaceutical compositions comprising the same. In some embodiments, the present disclosure provides for methods of treating diseases or conditions in a subject in need thereof, comprising administering one or more compounds disclosed herein. In some embodiment, the disease is cancer, including breast cancer.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Computed Properties of C16H11FN2O3

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N737 – PubChem

Reference of 763114-26-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 763114-26-7, 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery.

LOW AFFINITY POLY(AD-RIBOSE) POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS

The present disclosure provides compounds of Formula (I) or (II), pharmaceutically acceptable salt, isotopic variant, stereoisomer, or a mixture thereof. Also provided are pharmaceutical compositions comprising a compound, methods of treating a poly(ADP-ribose)polymerase-1-mediated disease or disorder in a subject, methods of detecting a poly(ADP-ribose)polymerase-1-mediated neurodegenerative disease or disorder, or methods of monitoring cancer treatment in a subject. In some embodiments, the poly(ADP-ribose)polymerase-1-mediated disease or disorder is a neurodegenerative disease or cancer.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 763114-26-7. In my other articles, you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N751 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C8H5BrN2O, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 152265-57-1, Name is 7-Bromophthalazin-1(2H)-one, molecular formula is C8H5BrN2O

2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS

There is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula (1), and the use of a compound of Formula (1) as a medicament and in the treatment of cancer

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C8H5BrN2O, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 152265-57-1

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N706 – PubChem