Tag: M.W:200-300

Reference of 23928-47-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.23928-47-4, Name is 1,4-Dichloro-5-fluorophthalazine, molecular formula is C8H3Cl2FN2. In a article£¬once mentioned of 23928-47-4

PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3] triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 23928-47-4

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N679 – PubChem

Application of 763114-26-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid,introducing its new discovery.

HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a heterocyclic-imidazole derivative, a preparation method therefor, and a medical use thereof, and particularly to a new heterocyclic-imidazole derivative of general Formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof as a therapeutic agent, particularly as a poly(ADP-ribose)polymerase (PARP) inhibitor.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Application of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N738 – PubChem

Related Products of 53242-88-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 53242-88-9, Name is 4-(4-Chlorobenzyl)phthalazin-1(2H)-one,introducing its new discovery.

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-imidazolyl)alkyl]- 1(2H)-phthalazinones

A number of 4-substituted 2-[omega-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2 synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 53242-88-9, and how the biochemistry of the body works.Related Products of 53242-88-9

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N732 – PubChem

Synthetic Route of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

Simple preparation method 4 -substituted-methyl -1 – (2H) phthalazinone (by machine translation)

The invention relates to a simple preparation method. 4 -substituent methyl -1 – (2H) phthalazinone (I). The method utilizes diG substituted benzene (II) and a compound III compound in the presence of a solvent A and an alkali, and the compound, the compound of formula IV or the compound of formula IV and hydrazine hydrate are condensed to prepare 4 – (pyridin -4 – yl) methyl -1 – (2H) phthalazinone (IA) or 4 – (4 – fluoro -3 – carboxyphenyl) methyl -1 – (2H) phthalazinone (IB), respectively. The method can be used for preparing taditinib and ornisonil. The method is simple in technological process, high in reaction repeatability, easy to operate, good in product stability, and high in purity. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Synthetic Route of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N759 – PubChem

Electric Literature of 70724-23-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 70724-23-1, Name is 1-Chloro-6,7-dimethoxyphthalazine,introducing its new discovery.

Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase

Aldehyde oxidase is a molybdenum-containing enzyme distributed throughout the animal kingdom. Although this enzyme is capable of metabolizing a wide range of aldehydes and N-heterocyclic compounds, there is no reported detailed study of physicochemical requirements of the enzyme-substrate interactions. The aim of this study, therefore, was to investigate quantitatively the relationships between the kinetic constants of aldehyde oxidase-catalyzed oxidation of some phthalazine and quinazoline derivatives (as substrates) and their structural parameters. Multiple regression and stepwise regression analyses showed that polarity of phthalazines (expressed as dipole moment mu, cohesive energy density deltaT and an indicator variable for hydrogen-bond acceptor ability of R1 substituent, HBA) had a negative effect on the enzyme activity (leading to the reduction of Vmax and increase of Km). Electron withdrawing substituents in the quinazoline series are favorable for interaction with the enzyme. This finding and also the relationships of 1/Km of phthalazines with the energy of the lowest unoccupied molecular orbital and log Vmax/logKm of phthalazines with degree of bonding of the two nitrogen atoms in the molecules are consistent with the mechanism of action. The reaction involves a nucleophilic attack on an electron-deficient sp2-hybridized carbon atom and formation of an epoxide intermediate following the disruption of the aromatic structure.

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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N693 – PubChem

Electric Literature of 19064-73-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 19064-73-4, 4-Bromophthalazin-1(2H)-one, introducing its new discovery.

Imidazo[4,5-b]pyridyl quinolone cardiac stimulants

A series of novel heterobicyclic substituted 2-(1H)-quinolone compounds have been prepared, including the 3,4-dihydro derivatives thereof, wherein the heterobicyclic ring moiety is an optionally-substituted indolyl, phthalizinyl, benzimidazolyl, imidazopyridinyl, quinolinyl or isoquinolinyl group attached by an nitrogen or carbon atom of said group to the 6-position of the quinolone ring. The optional substituent is a C1 -C14 alkyl group located on either of the two heterobicyclic rings and/or an oxo group situated on the heterocyclic portion of said heterobicyclic ring system. These particular compounds are useful in therapy as cardiac stimulants and therefore, are of value in the treatment of various cardiac conditions. 6-{1(H)-Imidazo[4,5-b]pyridin-6-yl}-8-methyl-2-(1H)-quinolone represents a typical and preferred member compound. Methods for preparing these compounds from known starting materials are provided.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 19064-73-4. In my other articles, you can also check out more blogs about 19064-73-4

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Phthalazine – Wikipedia,
Phthalazine | C8H6N694 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C15H11ClN2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 53242-88-9

Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

If you are interested in 53242-88-9, you can contact me at any time and look forward to more communication. COA of Formula: C15H11ClN2O

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N729 – PubChem

Related Products of 1242156-59-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1242156-59-7, molcular formula is C12H13FN2O, introducing its new discovery.

INHIBITORS OF BRUTON’S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1242156-59-7 is helpful to your research. Related Products of 1242156-59-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N684 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C15H11ClN2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 53242-88-9

Ring-rearrangement during the Mitsunobu alkylation of phthalazinones and indazolols

The Mitsunobu alkylation of substituted phthalazinones and indazolols with cyclic hydroxy- and hydroxymethyl-substituted amines was investigated. In addition to the expected derivatives ring-narrowed and ring-enlarged rearrangement products were isolated and characterized by NMR spectroscopy. The occurence of these products can be explained by the existence of a bicyclic intermediate. The results of the reaction of phthalazinones with optically active amine compounds show a stereospecific reaction mechanism. The reaction of the phthalazinones leads to N-substituted products, while in the case of the indazolols O-substituted derivatives were isolated. A postulated bicyclic intermediate, 1-methyl-1-azoniabicyclo[3.2.0]heptane, was synthesized as chloride. VCH Verlagsgesellschaft mbH, 1996.

If you are interested in 53242-88-9, you can contact me at any time and look forward to more communication. COA of Formula: C15H11ClN2O

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N727 – PubChem

Synthetic Route of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

A method for preparing high-purity aurar handkerchief Nepal (by machine translation)

The invention discloses a method for preparing high-purity aurar handkerchief Nepal, is a 2-fluoro-5 – [(4-oxo -3,4-dihydrodi nitrogen phenodiazine-1-yl) methyl] benzoic acid as the starting material, is activated, aminolysis to obtain high-purity aurar handkerchief Nepal after crystallization, wherein the activation is to contain 2-fluoro-5 – [(4-oxo -3,4-dihydrodi nitrogen phenodiazine-1-yl) methyl] benzoic acid is added to a solution of carbonyl diimidazole activator, active amide intermediates made; without separation and purification of active amide intermediate, direct and 1-cyclopropanecarboxylic formyl piperazine aminolysis crystallization, aurar handkerchief Nepal prepared. The method of the invention the purity of the aurar handkerchief Nepal preparation of greater than 99.8%, the craft is simple, high yield, low cost, is more suitable for industrial production. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Synthetic Route of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N776 – PubChem