Tag: M.W:200-300

763114-26-7, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 763114-26-7

Phthalazinone derivatives pro or its pharmaceutically acceptable salt and its pharmaceutical composition and application (by machine translation)

The invention belongs to the technical field of pharmaceutical chemistry, in particular to a phthalazinone derivative pro or its pharmaceutically acceptable salt, also relates to a pharmaceutical composition and in the preparation of an anti-tumor drug. The present invention provides compounds having the structural formula (I) Of the phthalazinone derivatives prodrugs of good solubility in vivo, after administration into the body, by the metabolic release phthalazine ketone drug molecules, thereby greatly improving the phthalazine ketone group in vivo bioavailability of drug molecules, the phthalazine ketone drug molecules with the in vivo enzyme PARP to not reversible way binding to exert the drug efficacy, anti-tumor activity is prominent. (by machine translation)

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Phthalazine – Wikipedia,
Phthalazine | C8H6N739 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. 763114-26-7, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 763114-26-7

Synthesis method of (by machine translation)

The invention discloses a synthesis method of ornafinil, which: comprises oxo – 1111,3-dihydroisobenzofuran – 1 (3 – 1-yl methyl) benzoyl chloride ;(3 – fluoro – 5-dihydroisobenzofuran -) 1 1-yl 2 – methyl- yl 2 – methyl-yl-)-methylbenzoyl chloride reacted with oxalyl chloride to react with] oxalyl ;2 – benzoyl-benzoic acid reaction) to form oxironicol], 2 – [( ()-oxo) – 3333,]-2 – dihydrodiazonaphthalene – 1 1])-)- 93%. (by machine translation)

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Phthalazine – Wikipedia,
Phthalazine | C8H6N733 – PubChem

763114-26-7, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery.

A method for preparing aurar handkerchief Nepal (by machine translation)

The invention discloses a method for preparing aurar handkerchief Nepal, in order to 5?aospaceao(Bromomethyl)?2?Fluorobenzoic acid methyl ester as the raw material, and catechol borane to borated reaction to obtain compound 3;aospaceaocompound 3 obtained by the Suzuki coupling reaction of compound 5;aospaceaocompound 5 obtained by the hydrolysis reaction of compound 6;aospaceaocompound 6 under the action of catalyst in the CDI, with compound 7 aurar handkerchief Nepal obtained by the reaction. The raw materials of this invention is easy to obtain, route is short, operation and after treatment is simple, the mild reaction conditions in each step, each step of the reaction yield is 90% aospaceaoor more, of the prior art the total yield of 49% aospaceaoto 82.3%, high purity, is friendly to the environment, is suitable for industrial production. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.763114-26-7, you can also check out more blogs about763114-26-7

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Phthalazine – Wikipedia,
Phthalazine | C8H6N748 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 763114-26-7. In a patent£¬Which mentioned a new discovery about 763114-26-7, molcular formula is C16H11FN2O3, introducing its new discovery.

HETEROCYCLIC DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF

Disclosed are heterocyclic derivatives, methods for making them, compositions containing the same and uses thereof. Particularly, their pharmaceutical use as inhibitors of PARP is disclosed

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 763114-26-7, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 763114-26-7

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Phthalazine – Wikipedia,
Phthalazine | C8H6N740 – PubChem

152265-57-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 152265-57-1, molecular formula is C8H5BrN2O, introducing its new discovery.

CONDENSED RING DERIVATIVE, AND PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.152265-57-1, you can also check out more blogs about152265-57-1

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Phthalazine – Wikipedia,
Phthalazine | C8H6N710 – PubChem

763114-26-7, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery.

A 4 – piperidyl ketone compound and its preparation method and application (by machine translation)

The invention discloses a 4 – piperidine ketone compound and its preparation method and application. The compounds have the following general structure , Wherein the benzene ring is substituted Ar emulsifying heterocyclic. 5 – [(3, 4 – Dihydro – 4 – oxo – 1 – taitai qin base) methyl] – 2 – fluoro benzoic acid first with 4 – piperidone hydrochloride condensation, then condensation with an aromatic aldehyde under alkaline conditions to obtain the compound. The compound or its pharmaceutically acceptable salt has potent PARP1 inhibitory activity, can be used for treating diseases or cancer drug used for prevention and/or treating PARP1 related diseases. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.763114-26-7, you can also check out more blogs about763114-26-7

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Phthalazine – Wikipedia,
Phthalazine | C8H6N771 – PubChem

678193-44-7, In an article, published in an article,authors is Carling, Robert W., once mentioned the application of 678193-44-7, Name is 1,4-Dichloro-5-methylphthalazine,molecular formula is C9H6Cl2N2, is a conventional compound. this article was the specific content is as follows.

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity gamma-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with alpha2, alpha3, and alpha5-Subtype Binding Selectivity over alpha1

Studies with our screening lead 5 and the literature compound 6 led to the identification of 6-benzyloxy-3-(4-methoxy)phenyl-1,2,4-triazolo[3,4-a]phthalazine 8 as a ligand with binding selectivity for the gamma-aminobutyric acid-A (GABA-A) alpha3- and alpha5-containing receptor subtypes over the GABA-A alpha1 subtype (Ki: alpha2 = 850 nM, alpha3 = 170 nM, alpha5 = 72 nM, alpha1 = 1400 nM). Early optimization studies identified the close analogue 10 (Ki: alpha2 = 16 nM, alpha3 = 41 nM, alpha5 = 38 nM, alpha1 = 280 nM) as a suitable lead for further study. High-affinity ligands were identified by replacing the 6-benzyloxy group of compound 10 with 2-pyridylmethoxy (compound 29), but binding selectivity was not enhanced (K i: alpha2 = 1.7 nM, alpha3 = 0.71 nM, alpha5 = 0.33 nM, alpha1 = 2.7 nM). Furthermore, on evaluation in xenopus oocytes, 29 was discovered to be a weak to moderate inverse agonist at all four receptor subtypes alpha1, -7%; alpha2, -5%; alpha3, -16%; alpha5, -5%). Replacement of the 3-phenyl group of 29 with alternatives led to reduced affinity, and smaller 3-substituents led to reduced efficacy. Methyl substitution of the benzo-fused ring of 29 at the 7-, 8-, and 10-positions resulted in increased efficacy although selectivity was abolished. Increased efficacy and retention of selectivity for alpha3 over alpha1 was achieved with the 7,8,9,10-tetrahydro-(7,10-ethano)-phthalazine 62. Compound 62 is currently one of the most binding selective GABA-A alpha3-benzodiazepine-site partial agonists known, and although its selectivity is limited, its good pharmacokinetic profile in the rat (33% oral bioavailability after a 3 mg/kg dose, reaching a peak plasma concentration of 179 ng/mL; half-life of 1 h) made it a useful pharmacological tool to explore the effect of a GABA-A alpha2/alpha3 agonist in vivo.

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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N677 – PubChem

763114-26-7, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 763114-26-7

Phthalazinone derivatives, and preparation method and application thereof (by machine translation)

The invention belongs to the field, relating to the field of pharmaceutical chemistry, and relates to an application of phthalazinones, geometric isomers or pharmaceutically acceptable salts, as shown in general formula (I), and a preparation method and application thereof in preparation of drugs for preventing or treating polyadenine diphosphoribose polymerase chain resistance related diseases. (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 763114-26-7, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 763114-26-7

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Phthalazine – Wikipedia,
Phthalazine | C8H6N765 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, 763114-26-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Article, authors is Reilly, Sean W.£¬once mentioned of 763114-26-7

Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant

Poly(ADP-ribose)polymerase-1 inhibitor (PARPi) AZD2461 was designed to be a weak P-glycoprotein (P-gp) analogue of FDA approved olaparib. With this chemical property in mind, we utilized the AZD2461 ligand architecture to develop a CNS penetrant and PARP-1 selective imaging probe, in order to investigate PARP-1 mediated neuroinflammation and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Our work led to the identification of several high-affinity PARPi, including AZD2461 congener 9e (PARP-1 IC50 = 3.9 ¡À 1.2 nM), which was further evaluated as a potential 18F-PET brain imaging probe. However, despite the similar molecular scaffolds of 9e and AZD2461, our studies revealed non-appreciable brain-uptake of [18F]9e in non-human primates, suggesting AZD2461 to be non-CNS penetrant.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 763114-26-7

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Phthalazine – Wikipedia,
Phthalazine | C8H6N795 – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 763114-26-7, molcular formula is C16H11FN2O3, introducing its new discovery. 763114-26-7

HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER

Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R 1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 763114-26-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N752 – PubChem