Tag: M.W:200-300

Application of 201611-92-9, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, SMILES is CC(SC(C1=CC=CC=C1)=S)(C#N)CCC(O)=O, belongs to phthalazine compound. In a article, author is Azarifar, Davood, introduce new discover of the category.

Tetrakis(acetonitrile) copper(I) hexafluorophosphate, [Cu(CH3CN)(4)]PF6, was explored as an efficient catalyst to promote the three-component reaction of aryl aldehydes, dimedone and urazole or phthalhydrazide to afford the corresponding triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione derivatives respectively in high yields. The reactions were conducted at 80-100 degrees C under solvent-free conditions. The catalyst was easily prepared from available and inexpensive materials and was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity.

Application of 201611-92-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 201611-92-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of Sodium 2-formylbenzenesulfonate, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Zhao, Xiao-Na, introduce new discover of the category.

A highly efficient magnetic CoFe2O4 chitosan sulfonic acid nanoparticle (CoFe2O4-CS-SO3H) was prepared and applied for one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones by condensation of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione and aldehydes under solvent-free conditions at 80 degrees C. The magnetic nanocatalyst could be readily recovered by applying an external magnet and recycled several times without significant loss of its catalytic activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1008-72-6. Application In Synthesis of Sodium 2-formylbenzenesulfonate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, belongs to phthalazine compound. In a document, author is Chate, Asha V., introduce the new discover, Category: phthalazines.

An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol% beta-cyclodextrinvia a one-pot multicomponent reaction of aldehyde, dimedone, hydrazine hydrate with succinic anhydrideiphthalic anhydride in water at 80 degrees C for first time. The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains. The outcome of the screening study showed that compound 6d, 6f and 7n exhibited excellent activity against E. coil. Whereas, compound 6f and 6 h exhibited excellent activity against P. aeurginosa, and compound 6c, and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S. aureus and B. subtilis when compared with Ampicillin (standard control). The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 1,3-Dibromobenzene, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 108-36-1, Name is 1,3-Dibromobenzene, SMILES is BrC1=CC(Br)=CC=C1, belongs to phthalazine compound. In a article, author is Azarifar, Davood, introduce new discover of the category.

Novel urea-functionalized silica-coated magnetic core-shell Fe3-x Ti (x) O-4 nanoparticles were prepared and fully characterized by different methods such as Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction, and thermogravimetric analyses. These magnetic nanoparticles have been explored as highly efficient and recoverable heterogeneous nanocatalyst for one-pot three-component reactions under mild conditions for the synthesis of diverse range of 5-oxo-dihydropyrano[3,2-c]chromenes known as coumarins and 1H-pyrazolo[1,2-b] phthalazine-5,10-diones in high yields. Simple isolation of the products, use of green solvent, and magnetically easy isolation and reusability of the catalyst with no significant loss of activity are the main advantages of the present method.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 108-36-1. Application In Synthesis of 1,3-Dibromobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, in an article , author is Soheilizad, Mehdi, once mentioned of 402-49-3, Synthetic Route of 402-49-3.

An efficient and simple method for the synthesis of aliphatic and aromatic 1H-indazolo[2,1-b]phthalazinetrione derivatives through a one-pot three-component condensation of phthalhydrazide, aldehyde, and dimedone in the presence of boron sulfonic acid as a reusable and efficient catalyst under solvent-free conditions is described. The reusability of catalyst, good to excellent yields, short reaction times, and the avoidance of harsh reagents are the main advantages of this method. .

Synthetic Route of 402-49-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 402-49-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 80382-23-6, We’ll be discussing some of the latest developments in chemical about CAS: 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is Shalkouhi, Somaye Nikzad, introduce new discover of the category.

The surface of Fe3O4 magnetic nanoparticles (MNPs) was modified by L-cysteine through condensation of COOH groups of L-cysteine and OH groups on the surface of Fe3O4. The -SH group of prepared Fe3O4@Cys MNPs oxidized to -SO3H group and Fe3O4@Cys-SO3H as an environmentally friendly magnetic nanoparticle was prepared. The MNPs were characterized by FT-IR, XRD, SEM and TEM studies. Then, the catalytic activity of the MNPs was evaluated as an effective and reusable catalyst for one-pot synthesis of 2H-indazolo [1,2-b] phthalazine-triones derivatives. The results show that the catalytic activity of Fe3O4@Cys-SO3H was comparable to that of other reported heterogeneous and homogeneous catalysts.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Application of 83-53-4, 83-53-4, Name is 1,4-Dibromonaphthalene, SMILES is C1=CC=CC2=C(C=CC(=C12)Br)Br, in an article , author is Behalo, Mohamed S., once mentioned of 83-53-4.

One-pot synthesis of 1,3,4-oxadiazole derivatives was achieved by treatment of 2-((4-(phenoxathiin-2-yl) phthalazin-1-yl)oxy) acetohydrazide with aromatic aldehydes in the presence of cerium(IV) ammonium nitrate in dichloromethane. This facile method was confirmed by the cyclization-oxidation reaction of the corresponding hydrazone by cerium(IV) ammonium nitrate to afford the same 1,3,4-oxadiazoles. Also, the reaction of 2-((4-(phenoxathiin-2-yl)phthalazin-1-yl) oxy) acetohydrazide with aromatic carboxylic acids in the presence of cerium(IV) ammonium nitrate in polyethylene glycol afforded 1,3,4-oxadiazole derivatives. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data. Most of the synthesized products were evaluated for their antibacterial and antifungal activities and showed potent to weak activity.

Reference of 83-53-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 83-53-4 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 1878-68-8, Name is 4-Bromophenylacetic acid, molecular formula is C8H7BrO2, belongs to phthalazine compound. In a document, author is Wang, Yuxiang, introduce the new discover, Related Products of 1878-68-8.

An efficient and practical cascade oxidation/halogenoaminocyclization of trifluoromethylated homoallylic N-acylhydrazines is developed. The protocol enables an efficient access to various biologically interesting CF3-containing pyrazoline compounds from readily accessible trifluoromethylated homoallylic N-acylhydrazines in good to excellent yields under mild conditions without any other additives or catalysts. The produced pyrazoline compounds can be further manipulated to other more complicated derivatives through transformation of residual halogen atom.

Related Products of 1878-68-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1878-68-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Yuan, Chunhao, once mentioned the application of 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl, molecular weight is 205.4795, MDL number is MFCD00040714, category is phthalazine. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/622-95-7.html.

The phosphine-catalyzed [3 + 2] cycloaddition between phthalazinium dicyanomethanides and allenoates, has been achieved in dichloromethane at room temperature, providing a broad range of novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88-99% yield). All reactions are operationally simple and proceed very fast under mild reaction conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 622-95-7. HPLC of Formula: https://www.ambeed.com/products/622-95-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Shahsavani, Mohammad Bagher, once mentioned the application of 789-25-3, Name is Triphenylsilane, molecular formula is C18H16Si, molecular weight is 260.4052, MDL number is MFCD00003003, category is phthalazine. Now introduce a scientific discovery about this category, Reference of 789-25-3.

Human serum albumin (HSA) principally tasks as a transport carrier for a vast variety of natural compounds and pharmaceutical drugs. In the present study, two structurally related binuclear Pt (II) complexes containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis, cis-[Me2Pt(mu-NN)(mu dppm) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were used to investigate their interaction with HSA, using UV Vis absorption spectroscopy, fluorescence, circular dichroism and molecular dynamic analyses. The spectroscopic results suggest that upon binding to HSA, the binuclear Pt (II) complexes could effectively induce structural alteration of this protein. These complexes can bind to HSA with the binding affinities of the following order: complex 2 > complex 1. Moreover, the thermodynamic parameters of binding between these complexes and HSA suggested the existence of entropy-driven spontaneous interaction, which mostly dominated with the hydrophobic forces. The ANS fluorescence results also indicated that two binuclear Pt (II) complexes were competing for the binding to the hydrophobic regions on HSA. In addition, competitive displacement assay and docking simulation study revealed that complexes 1 and 2 bind to the drug binding sites II and Ion HSA, respectively. Furthermore, complex 2, with the higher binding affinity for HSA, shows more denaturing effect on this protein. Considering the protein structural damages in the pathway of harmful side effects of platinum drugs, complex 1 with the moderate binding affinity and low denaturing effect might be of high significance. (C) 2016 Elsevier B.V. All rights reserved.

Synthetic Route of 789-25-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem