Tag: M.W:200-300

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, molecular formula is , belongs to phthalazine compound. In a document, author is El-Shamy, Ibrahim E., HPLC of Formula: https://www.ambeed.com/products/17852-52-7.html.

1-Chloro-4-(2,4,6-trimethylphenyl) phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using H-1 NMR, C-13 NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Interested yet? Keep reading other articles of 17852-52-7, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/17852-52-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Synthetic Route of 4271-30-1, 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, in an article , author is Zaib, Sumera, once mentioned of 4271-30-1.

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural products and effective therapeutic drugs. Among them, phthalazines have been recognized as remarkable structural leads in medicinal chemistry due to their wide application in pharmaceutical and agrochemical industries. Accessing such challenging pharmaceutical agents/drug candidates with high chemical complexity through synthetically efficient approaches remains an attractive goal in the contemporary medicinal chemistry and drug discovery arena. In this review, we focus on the recent developments in the synthetic routes towards the generation of phthalazine-based active pharmaceutical ingredients and their biological potential against various targets. The general reaction scope of these innovative and easily accessible strategies was emphasized focusing on the functional group tolerance, substrate and coupling partner compatibility/limitation, the choice of catalyst, and product diversification. These processes were also accompanied by the mechanistic insights where deemed appropriate to demonstrate meaningful information. Moreover, the rapid examination of the structure-activity relationship analyses around the phthalazine core enabled by the pharmacophore replacement/integration revealed the generation of robust, efficient, and more selective compounds with pronounced biological effects. A large variety of in silico methods and ADME profiling tools were also employed to provide a global appraisal of the pharmacokinetics profile of diaza-heterocycles. Thus, the discovery of new structural leads offers the promise of improving treatments for various tropical diseases such as tuberculosis, leishmaniasis, malaria, Chagas disease, among many others including various cancers, atherosclerosis, HIV, inflammatory, and cardiovascular diseases. We hope this review would serve as an informative collection of structurally diverse molecules enabling the generation of mature, high-quality, and innovative routes to support the drug discovery endeavors.

Synthetic Route of 4271-30-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4271-30-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 1878-68-8, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, belongs to phthalazine compound. In a article, author is Safari, Niloufar, introduce new discover of the category.

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C-4(H-DABCO)(2)][HSO4](4) is easily prepared and characterized using FT-IR, H-1 NMR,C-13 NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method. (C) 2019 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1878-68-8, in my other articles. Product Details of 1878-68-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: https://www.ambeed.com/products/24650-42-8.html, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, SMILES is COC(OC)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Gan, Min, introduce new discover of the category.

Amino-acid-derived phthalazine catalysts have been designed and synthesized for enantioselective halolactonization of prochiral dienoic acids. The scope of the reaction is evidenced by 17 examples of Spiro a-exo-methylene-halolactones with up to 99.8% enantiomeric excess. The resulting enantio-enriched Spiro halolactone products are found to exhibit potent antitumor effects. In addition, both antipodes of products with equally excellent enantioselevity could be obtained since a pair of enantiomeric catalysts is guaranteed.

Interested yet? Read on for other articles about 24650-42-8, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/24650-42-8.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 1676-73-9, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 1676-73-9, Name is H-Glu(OBzl)-OH, SMILES is N[C@@H](CCC(OCC1=CC=CC=C1)=O)C(O)=O, belongs to phthalazine compound. In a article, author is Machura, B., introduce new discover of the category.

Six cadmium(II) compounds [Cd(Qnz)(2)(SCN)(2)](n) (1), [Cd(Qnz)(2)(dca)(2)](n) (2), [Cd(Qnz)(2)(N-3)(2)]}(n) (3), [Cd-2(mu-SCN-kappa N-2:S)(2)(SCN)(2)(Ptz)(4)(H2O)(2)] (4), [Cd(Ptz)(2)(dca)(2)](n) (5) and [Cd(Ptz)(MeOH)(N-3)(2)](n) (6) were successfully synthesized and characterized by single-crystal diffraction. Additionally, the samples were characterized by powder X-ray diffraction (PXRD), thermal analysis and IR spectroscopy. The fluorescence properties of 1, 2, 3, 5 and 6 were studied in solid state, while emission spectrum of 4 was recorded in methanolic solution. All they were compared with the fluorescence properties of the free ligands. Additionally, the electronic spectrum of 4 was investigated at the TDDFT level employing B3LYP functional in combination with LANL2DZ. (C) 2013 Elsevier Ltd. All rights reserved.

Application of 1676-73-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1676-73-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Recommanded Product: 93-28-7, 93-28-7, Name is Eugenol Acetate, SMILES is CC(OC1=CC=C(CC=C)C=C1OC)=O, in an article , author is Soheilizad, Mehdi, once mentioned of 93-28-7.

An efficient and simple method for the synthesis of aliphatic and aromatic 1H-indazolo[2,1-b]phthalazinetrione derivatives through a one-pot three-component condensation of phthalhydrazide, aldehyde, and dimedone in the presence of boron sulfonic acid as a reusable and efficient catalyst under solvent-free conditions is described. The reusability of catalyst, good to excellent yields, short reaction times, and the avoidance of harsh reagents are the main advantages of this method. .

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 93-28-7. Recommanded Product: 93-28-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, molecular formula is C13H13NO2S2, Related Products of 201611-92-9, belongs to phthalazine compound, is a common compound. In a patnet, author is Selvaraj, Keerthana, once mentioned the new application about 201611-92-9.

Novel one-pot synthesis naphtho[2,3-g]phthalazine (1a-1k) of Mannich base derivatives can be achieved via grindstone chemistry using a Tel-Cu-NPs (telmisartan-copper nanoparticles) catalyst. This method offers efficient mild reaction conditions and high yields. Tyrosinase inhibitory activity was evaluated for all synthesized compounds, along with analysis of kinetic behavior and molecular docking studies. The synthesized compound, 1c was (IC50 = 11.5 mu M) more active than kojic acid (IC50 = 78.0 mu M). Lineweaver Burk plots were used to analyze the kinetic behavior of the most active compound 1c, it was reversible and competitive behavior. Compound 1c and kojic acid occurred in the presence of 2-hydroxyketone, which has the same inhibitory mechanism. The molecular docking of compound 1c and the control kojic acid were docked against 2Y9X protein via the Schrodinger Suite. The compound 1c showed a respectable dock score (-5.6 kcal/mol) compared to kojic acid with a dock score of (-5.2 kcal/mol) in the 2Y9X protein. Cytotoxicity activity was also evaluated by using HepG2 (liver), MCF-7 (breast), and HeLa (cervical) cancer cell lines, and high activity for 1c (GI(50) = 0.01, 0.03, and 0.04 mu M, respectively) against all cell lines was found compared to standard and other compounds. Therefore, this study succeeded in testing a few promising molecules as potential antityrosinase agents.

Related Products of 201611-92-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 201611-92-9 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 83-53-4, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 83-53-4, Name is 1,4-Dibromonaphthalene, SMILES is C1=CC=CC2=C(C=CC(=C12)Br)Br, belongs to phthalazine compound. In a article, author is Pavithra, Dalavai, introduce new discover of the category.

A solvent-free synthesis of 2H-indazolo[1,2-b]phthalazinetriones 4 and pyrazolo[1,2-b]phthalazines 6 scaffolds using benzyl alcohol 1 via TEMPO/CAN and TBAB mediated aerobic oxidation, sequential addition-cyclization with phthalhydrazide 2 and beta-diketones 3,5 is reported. The experimental strategy offers several advantages, such as simple workup, inexpensive chemicals without any use of solvents, and short reaction time. [GRAPHICS] .

Synthetic Route of 83-53-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 83-53-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Application of 2128-93-0, 2128-93-0, Name is 4-Benzoylbiphenyl, molecular formula is C19H14O, belongs to phthalazine compound. In a document, author is Wang, Chenglin, introduce the new discover.

We report herein the design and synthesis of a series of structural modified dimethylpyridazine compounds as novel hedgehog signaling pathway inhibitors. The bicyclic phthalazine core and 4-methylamino- piperidine moiety of Taladegib were replaced with dimethylpyridazine and different azacycle building blocks, respectively. The in vitro Gli-luciferase assay results demonstrate that the new scaffold still retained potent inhibitory potency. Piperidin-4-amine moiety was found to be the best linker between pharmacophores dimethylpyridazine and fluorine substituted benzoyl group. Furthermore, the optimization of 1-methyl-1H-pyrazol and 4-fluoro-2-(trifluoromethyl) benzamide by different aliphatic or aromatic rings were also investigated and the SAR were described. Several new derivatives were found to show potent Hh signaling inhibitory activity with nanomolar IC50 values. Among these compounds, compound 11c showed the highest inhibitory potency with an IC50 value of 2.33 nM, which was comparable to the lead compound Taladegib. In vivo efficacy of 11c in a ptch(+/)-p53(-/-) mouse medulloblastoma allograft model also indicated encouraging results. (C) 2018 Elsevier Ltd. All rights reserved.

Application of 2128-93-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2128-93-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 502496-34-6, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Zhao, Shanshan, introduce new discover of the category.

Poly (phthalazine ether sulfone ketone) (PPESK)/TiO2 organic-inorganic composite ultrafiltration (OF) membranes with enhanced performance for high temperature condensed water treatment were prepared using a phase-inversion method. The effects of TiO2 concentration on the membrane morphologies, physic-chemical properties, membrane permeability and antifouling performance were investigated and discussed. The SEM result reveals that the penetrated finger-like structure in sublayer is suppressed, and sponge-like structure begins to be developed. The mechanical strength and thermal stability of composite membrane are improved due to the existence of hydrogen bond between TiO2 and polymer. The permeate flux is also enlarged due to the improved hydrophilicity and porosity. Compared with neat PPESK membrane, the composite membranes present improved antifouling properties, showing lower filtration resistances, MEI values and better flux recover property during high temperature condensed water treatment. The optimal addition amount of TiO2 is 2 wt.%. The high temperature condensed water with excess oil and iron can be treated efficiently using PPESK/TiO2 composite membrane. The turbidity of feed solution is almost removed. The oil and iron concentrations in permeate solution are 0.89 mg/L and 26.4 mu g/L which meet the Quality Criterion of Water and Steam for Steam Power Equipment in China. (C) 2012 Elsevier B.V. All rights reserved.

Reference of 502496-34-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 502496-34-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem