Tag: M.W:200-300

Electric Literature of 402-49-3, We’ll be discussing some of the latest developments in chemical about CAS: 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, SMILES is FC(C1=CC=C(CBr)C=C1)(F)F, belongs to phthalazine compound. In a article, author is Albota, Florin, introduce new discover of the category.

1,3-Dipolar cycloaddition reaction of sydnone-N-ylides, as model bis(1,3-dipoles), with acetylenic dipolarophiles in 1,2-epoxybutane under reflux gave exclusively pyrroloazines containing a sydnone moiety that resulted by preferred reaction of the N-ylide 1,3-dipole with the acetylenic dipolarophiles. The assembled sydnone-ylide hybrid structures were generated in situ from N-heteroaromatic bromides. The structure of the new compounds was assigned by IR and NMR spectroscopy and confirmed by X-ray analysis for a representative compound. (C) 2015 Elsevier Ltd. All rights reserved.

Electric Literature of 402-49-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 402-49-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Healthcare careers for chemists are once again largely based in laboratories, Synthetic Route of 54381-16-7, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, belongs to phthalazine compound. In a document, author is Zaky, Omnyia Said, introduce the new discover.

A simple green and efficient one-pot multi-component synthesis of 1H-pyrozolo[1,2-b]phthalazine-5,10-diones and 2H-indazolo[2,1-b]phthalazine-triones has been developed utilizing one-pot multi-component reaction of aromatic aldehydes, active methylene reagents, phthalic anhydride, and hydrazine hydrate or alternatively phthalhydrazide in glycerol without catalyst under controlled microwave heating. The current synthetic protocol offers several advantages such as excellent yields, high EcoScale and atom economy, simple working up reactants and products, and the absence of hazardous catalysts or solvents.

Synthetic Route of 54381-16-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 54381-16-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Recommanded Product: 81-16-3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazine compound. In a document, author is Romero, Angel H..

With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in the world. A structure-activity relationship permitted to identify two phthalazines containing nitroheterocyclic moiety 31 and 3m as promising new lead compounds. These compounds showed a significant antileishmanial activity against promastigote form of L. braziliensis, with EC50 values in sub-micromolar and nanomolar ranges. The phthalazine 31 also displayed a selective and excellent activity against the clinically relevant intracellular amastigotes form, with a EC50 value in sub-micromolar range (0.59 mu M), without affecting the viability of the host cells. Oxidative stress was identified as the possible mode of action of the most active phthalazine. Considering their significant antileishmanial activity and ease synthesis, the phthalazine containing nitroheterocyclic represents a promising agent against Leishmania braziliensis for the rational design of new leads. (C) 2017 Elsevier Masson SAS. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. Recommanded Product: 81-16-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 2215-77-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2215-77-2, Name is 4-Phenoxybenzoic acid, SMILES is OC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1, belongs to phthalazine compound. In a article, author is Yuan, Chunhao, introduce new discover of the category.

The Cu(I)-catalyzed highly enantioselective [3 + 3] cycloaddition between two different 1,3-dipoles, phthalazinium dicyanomethanides and iminoester-derived azomethine ylides, has been achieved under mild reaction conditions, providing novel chiral heterocyclic compounds, 2,3,4,11b-tetrahydro-1H-pyrazino[2,1-a]phthalazine derivatives, in high yields with excellent diastereo- and enantioselectivies (up to 99% yield, 99% ee, >20:1 dr).

Application of 2215-77-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 83-53-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 83-53-4, Name is 1,4-Dibromonaphthalene, SMILES is C1=CC=CC2=C(C=CC(=C12)Br)Br, belongs to phthalazine compound. In a article, author is Bader, Samuel L., introduce new discover of the category.

Recently, we described the first inverse electron demand Diels-Alder reaction of 1,2-diazene catalyzed by a bidentate Lewis acid. Herein we investigate 1,2-phenylenediboronic esters as potential catalysts for this transformation offering higher stability and easier handling than the currently used boranthracene derivatives. Different 1,2-phenylenediboronic esters were prepared and their ability to form bidentate coordination complexes with phthalazine was analyzed. Although a 1:1 complex was observed, X-ray analysis revealed binding only in a monodentate fashion.

Synthetic Route of 83-53-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 83-53-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Gao, Cheng-Zhi, once mentioned the application of 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5, molecular weight is 266.25, MDL number is MFCD00065696, category is phthalazine. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/4474-86-6.html.

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 +/- 1.25 nM) and MDA-MB-436 cancer cell (11.62 +/- 2.15 mu M), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 +/- 0.91 mu M) which was stronger than neostigmine (12.01 +/- 0.45 mu M) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4474-86-6, COA of Formula: https://www.ambeed.com/products/4474-86-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Mei, Qunbo, once mentioned the application of 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, molecular formula is C6H10ClN3O2S, molecular weight is 223.68, MDL number is MFCD00052262, category is phthalazine. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/17852-52-7.html.

Two novel bis-cyclometalated iridium(III) complexes, Ir(ECPC)(2)(pic) and Ir(TPC)(2)(pic) (HECPC, 3-(4-(9H-carbazol-9-yl)phthalazin-1-yl)-9-ethyl-9H-carbazole; HTPC, 4-(4-(9H-carbazol-9-yl)phthalazin-1-yl)-N,N-diphenylaniline, pic = 2-picolinic acid) were synthesized in moderate yield under mild synthetic conditions, and their electrical and photophysical properties were characterized with respect to their application as a phosphorescent emitter in polymer light-emitting diodes (PLEDs). The devices based on these complexes with the structure of ITO/PEDOT:PSS (40 nm)/70%PVK:30%PBD:x% iridium(III) complex (70 nm)/TPBI (30 nm)/Ba (1.5 nm)/Al (120 nm) were fabricated with highly external quantum efficiency. The device based on Ir(ECPC)(2)(pic) exhibited a maximum external quantum efficiency of 16.3% and a luminance of 1484 cd/cm(2); while the device based on Ir(TPC)(2)(pic) showed a maximum external quantum efficiency of 11.9% and a Commission International de L’Eclairage (CIE) coordinates of (0.695,0.289). The results showed that the two new bis-cyclometalated iridium(III) complexes can be used as emitters and applied in saturated red phosphorescent organic light-emitting diodes (PHOLEDs). (c) 2012 Elsevier Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 17852-52-7, Formula: https://www.ambeed.com/products/17852-52-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, molecular formula is C10H9NO3S, belongs to phthalazine compound. In a document, author is Shah, Nimesh M., introduce the new discover, Formula: https://www.ambeed.com/products/81-16-3.html.

A simple and efficient method has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives through a one-pot three-component condensation reaction of 2-chloro-3-formyl quinolines, malononitrile/ethyl cyanoacetate and 2,3-dihydro-1,4-phthalazinedione using a catalytic amount of piperidine in refluxing ethanol. All the synthesized compounds were screened for their antibacterial activity against a panel of pathogenic strains of bacteria and fungi.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-16-3. Formula: https://www.ambeed.com/products/81-16-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Lee, Jae Jun, once mentioned the application of 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, molecular formula is C16H16O3, molecular weight is 256.2964, MDL number is MFCD00008475, category is phthalazine. Now introduce a scientific discovery about this category, Recommanded Product: 2,2-Dimethoxy-2-phenylacetophenone.

A new multifunctional and highly selective chemosensor 1 for Co2+ and Cu2+ was designed and synthesized. 1 could simultaneously detect both Co2+ and Cu2+ by changing its color from pale yellow to pink and to orange in a near-perfect aqueous solution. The binding modes of 1 to Co2+ and Cu2+ were determined to be a 2 : 1 complexation stoichiometry through Job’s plot, ESI-mass spectrometry analysis and H-1 NMR titration. The detection limits (1.5 and 2.1 mu M) of 1 for Co2+ and Cu2+ were lower than the DEP guidelines (1.7 mu M for Co2+) and the WHO guidelines (31.5 mu M for Cu2+) for drinking water. The chemosensor 1 could be used to quantify Co2+ and Cu2+ in water samples. Moreover, 1 could be used as a practical, visible colorimetric test kit for both Co2+ and Cu2+. The sensing mechanisms of Co2+ and Cu2+ by 1 were supported by theoretical calculations.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 24650-42-8, Recommanded Product: 2,2-Dimethoxy-2-phenylacetophenone.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 789-25-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazine compound. In a article, author is Shahsavani, Mohammad Bagher, introduce new discover of the category.

Human serum albumin (HSA) principally tasks as a transport carrier for a vast variety of natural compounds and pharmaceutical drugs. In the present study, two structurally related binuclear Pt (II) complexes containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis, cis-[Me2Pt(mu-NN)(mu dppm) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were used to investigate their interaction with HSA, using UV Vis absorption spectroscopy, fluorescence, circular dichroism and molecular dynamic analyses. The spectroscopic results suggest that upon binding to HSA, the binuclear Pt (II) complexes could effectively induce structural alteration of this protein. These complexes can bind to HSA with the binding affinities of the following order: complex 2 > complex 1. Moreover, the thermodynamic parameters of binding between these complexes and HSA suggested the existence of entropy-driven spontaneous interaction, which mostly dominated with the hydrophobic forces. The ANS fluorescence results also indicated that two binuclear Pt (II) complexes were competing for the binding to the hydrophobic regions on HSA. In addition, competitive displacement assay and docking simulation study revealed that complexes 1 and 2 bind to the drug binding sites II and Ion HSA, respectively. Furthermore, complex 2, with the higher binding affinity for HSA, shows more denaturing effect on this protein. Considering the protein structural damages in the pathway of harmful side effects of platinum drugs, complex 1 with the moderate binding affinity and low denaturing effect might be of high significance. (C) 2016 Elsevier B.V. All rights reserved.

Synthetic Route of 789-25-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem