Tag: M.W:200-300

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid. In a document, author is Liu, Da-Chuan, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/23981-47-7.html.

The transcription factor nuclear factor-kappa B (NF-kappa B) controls many physiological processes including inflammation, immunity, and apoptosis. In this study, a novel series of 6-phenoxy-[1,2,4] triazolo[3,4-a] phthalazine-3-carboxamide derivatives were synthesized as potent anti-inflammatory agents, which acted on tumor necrosis factor (TNF-alpha) as inhibitors of NF-kappa B activation. We showed that compounds 6h (6-(2,4-dichlorophenoxy)-[1,2,4] triazolo[3,4-a] phthalazine-3-carboxamide) and 6i (6-(3-tolyloxy)[1,2,4] triazolo[3,4-a]phthalazine-3-carboxamide) showed more prominent anti-inflammatory activity than other compounds, with similar activities as the reference drug dihydrotanshinone; compound 6i showed the lowest cellular toxicity among the tested compounds. In vivo evaluation of the anti-inflammatory activity showed that compound 6i exhibited excellent anti-inflammatory activity with 58.19% inhibition at 50 mg/kg intraperitoneal (i.p.), with equal efficacy as the positive control indomethacin (100 mg/kg i.p.; 59.21% inhibition). (C) 2016 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 23981-47-7 help many people in the next few years. COA of Formula: https://www.ambeed.com/products/23981-47-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, formurla is C7H5BrFNO2. In a document, author is Levchenkov, S. I., introducing its new discovery. Formula: https://www.ambeed.com/products/502496-34-6.html.

Binuclear complexes of copper(II) with 1′-phthalazinylhydrazones of substituted salicylic aldehydes have been prepared and studied. Antiferromagnetic exchange interaction between copper(II) ions has been revealed in all the complexes. Taking advantage of quantum-chemical simulation, we have investigated the influence of the complexes structural isomerism on the character of the exchange interaction between the paramagnetic centers. X-ray absorbance spectroscopy afforded the structural parameters of coordination spheres of copper(II) ions; it has been demonstrated that dimerization occurred via the nitrogen atoms of phthalazine fragments.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 17852-52-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, SMILES is O=S(C1=CC=C(NN)C=C1)(N)=O.[H]Cl, belongs to phthalazine compound. In a article, author is Guo, Tongxun, introduce new discover of the category.

Several Pd(II) complexes with unconventional pyridazine- and phthalazine-derived carbene ligands were synthesized via direct oxidative addition of Cl derivatives of the alkylated diazine heterocycles to Pd(0) species. The alkylated ligand precursors are readily prepared from commercial starting materials, and oxidative addition is regioselective. DFT calculations confirm that the thermodynamically favored products are formed. Four complexes (1-4) have been fully characterized, including by X-ray crystallography. Attractive intramolecular pi-pi stacking between the electron-poor N-alkylated diazine heterocycles and adjacent phenyl groups of the PPh3 coligands is revealed by the solid-state structures.

Application of 17852-52-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 17852-52-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hollo, Berta, once mentioned the application of 93-28-7, Name is Eugenol Acetate, molecular formula is C12H14O3, molecular weight is 206.24, MDL number is MFCD00026191, category is phthalazine. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/93-28-7.html.

Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated. (C) 2014 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, SMILES is NNC1=CC=C(Br)C=C1.[H]Cl, belongs to phthalazine compound. In a document, author is Levchenkov, S. I., introduce the new discover, Category: phthalazines.

Binuclear complexes of copper(II) with 1′-phthalazinylhydrazones of substituted salicylic aldehydes have been prepared and studied. Antiferromagnetic exchange interaction between copper(II) ions has been revealed in all the complexes. Taking advantage of quantum-chemical simulation, we have investigated the influence of the complexes structural isomerism on the character of the exchange interaction between the paramagnetic centers. X-ray absorbance spectroscopy afforded the structural parameters of coordination spheres of copper(II) ions; it has been demonstrated that dimerization occurred via the nitrogen atoms of phthalazine fragments.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 622-88-8 is helpful to your research. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: phthalazines, 108-36-1, Name is 1,3-Dibromobenzene, molecular formula is C6H4Br2, belongs to phthalazine compound. In a document, author is Hirakawa, Shota, introduce the new discover.

A ruthenium complex containing a 1,9,10-anthyridine derivative, [Ru(L)(bpy)(2)](PF6)(2) ( [1] (PF6)(2); L = 1,13,14-triazadibenz[a,j]anthracene, bpy = 2,2′-bipyridyl), was synthesized. X-ray crystal structural analysis of [1](PF6)2 showed that L is coordinated to the Ru center as a bidentate ligand. When [1](PF6)(2) was dissolved in acetonitrile, a new complex incorporating one acetonitrile molecule, [Ru(L)(CH3CN)(bpy)(2)](PF6)(2) ([2] (PF6)(2)), was formed. X-ray crystallographic data revealed that, in [2](PF6)(2), L is coordinated to the Ru center in a monodentate fashion. The coordinated L in [2](PF6)(2) shows a unique haptotropic rearrangement in an acetonitrile solution.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 108-36-1. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 838-88-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), SMILES is NC1=CC=C(CC2=CC=C(C(C)=C2)N)C=C1C, belongs to phthalazine compound. In a article, author is Zhang, Yanxin, introduce new discover of the category.

High-performance pure near-infrared organic light-emitting materials and devices with full emission over 700 nm are still rare, though urgently needed. Iridium(iii) complexes have been proven to be an important class of NIR emitters. Herein, we report a new NIR homoleptic Ir(iii) complex, tris[1,4-di(5-n-octylthiophen-2-yl)benzo[g]phthalazine] iridium(iii) (Ir(dotbpa)(3)), with full emission beyond 700 nm with an iridium mass content as low as 10 wt%. Thanks to the introduction of flexiblen-octyl groups,Ir(dotbpa)(3)shows greatly improved solubility and excellent solution-processability in comparison with its counterpartIr(dtbpa)(3). By utilizing a multifunctional host, solution-processed NIR-OLEDs were fabricated with a simple structure of only three organic layers and they demonstrated a pure NIR emission starting from 725 nm and a peak at 850 nm with the maximum external quantum efficiency of 0.17%, which makes them the first example of pure NIR-OLEDs based on Ir(iii) emitters.

Synthetic Route of 838-88-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 838-88-0 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Pisal, Parshuram M., once mentioned the application of 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, molecular formula is C13H13NO2S2, molecular weight is 279.38, MDL number is MFCD10698690, category is phthalazine. Now introduce a scientific discovery about this category, SDS of cas: 201611-92-9.

Tetrabutylammonium bromide (TBAB) and cesium carbonate (Cs2O3) catalyzed, one-pot three-component synthesis of 2H-indazole[2,1b]phthalazine-1,6,11(13H)-triones was developed at room temperature in ethanol. Both electron donating and withdrawing groups are compatible under the optimized reaction parameters.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene. In a document, author is Khalil, Nadia A., introducing its new discovery. Safety of 4-Bromo-2-fluoro-6-nitrotoluene.

Novel 4-(4-bromophenyl)phthalazine derivatives connected via an alkyl spacer to amine or N-substituted piperazine were designed and synthesized as promising alpha-adrenoceptor antagonists. The structures of the phthalazine derivatives were established using elemental and spectral analyses. Twelve of the tested compounds displayed significant alpha-blocking activity. Molecular modeling studies were performed to rationalize the biological results. Among the tested compounds, 7j displayed the best-fitting score and the highest in vitro activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 502496-34-6 help many people in the next few years. Safety of 4-Bromo-2-fluoro-6-nitrotoluene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 7507-86-0, Name is 2-Bromo-5-methoxybenzaldehyde, SMILES is O=CC1=CC(OC)=CC=C1Br, belongs to phthalazine compound. In a document, author is Soliman, Saied M., introduce the new discover, Formula: https://www.ambeed.com/products/7507-86-0.html.

A new Schiff base derived from the antihypertensive hydralazine (LH) and its Co(III) complexes [CoL2] X*4H(2)O, where X = NO3 (1) or Cl (2), were synthesized and characterized using FTIR, UV-Vis,H-1 NMR spectroscopy as well as thermal analysis. The crystal structures of the three compounds have been determined using single crystal X-ray diffraction technique. The two complexes structure is strictly divided in a highly ordered part of the [CoL2](+) units and a disordered section containing the anions and sixteen crystal water molecules per unit cell. In the complexes, the two ligand anions (L-) chelate to the Co(III) through the nitrogen atoms in a tridentate meridional manner. The pyridine and phthalazine rings showed deviations from co-planarity in all compounds which attributed to the crystal packing effects as revealed by analysis of their molecular packing using Hirshfeld analysis and further supported by DFT calculations. The optimized structure of the [CoL2] NO3 as a model showed no co-planarity of the two rings while perfectly planar ligand units were predicted in the [CoL2](+) cation indicating that the intermolecular interactions with the nitrate counter anion have a major role in the deviations of the two ring moieties from planarity. The ligand anion (L-) optimized structure using B97D function which include dispersion model showed similar results while the functions (B3LYP and mPW1PW91) which include no dispersion model predicted perfectly planar arrangement. Atoms in molecules (AIM) studies predicted the strength of the Co-N interactions is in the order, Co-N(azomethine) > Co-N(phthalazine) > Co-N(pyridine) which are generally stronger in 2 than 1. The developmental toxicity of LH and its complexes were tested in zebrafish embryos. The ligand itself was very toxic with LC50 of just 2 mu M as compared to its metal complexes, whereas, at sub-lethal concentration the ligand perturbed the neurogenesis in zebrafish embryos. (C) 2017 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7507-86-0 is helpful to your research. Formula: https://www.ambeed.com/products/7507-86-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem