Tag: M.W:200-300

Related Products of 789-25-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazine compound. In a article, author is Almeida, Marilia O., introduce new discover of the category.

The fermentation of the endophyte Fusarium oxysporum SS46 and Fusarium oxysporum ATCC MYA 4623 with epigenetic modulator hydralazine in Czapek medium led to the isolation of 3-methyl-1,2,4-triazolo [3,4-alpha] phthalazine (1). The mechanism of biotransformation involves reaction with acetyl-CoA and further cyclization, and was unveiled using C-13-precursor. Additionally, AFLP technique for genomic DNA and differential gene expression (cDNA) analyses were applied for comparative profiling of the fungus under and without treatment with hydralazine. There was no change in the DNA profile of hydralazine-treated and non-treated cultures; however, cDNA-AFLP analyses showed a differential gene expression in the cultures after treatment of the fungi with hydralazine.

Related Products of 789-25-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 789-25-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazine compound. In a article, author is Magyari, Jozef, introduce new discover of the category.

New coordination compounds have been synthesized by reacting Zn(II) and Co(II) nitrate or acetate in the presence of triethylamine with Schiff-base ligands containing diazine-ring, pyridine-2-carbaldehyde phthalazine-1-hydrazone,HzPYH, and di(2-pyridyl)ketone 3-chloro-pyridazine-6-hydrazone,HpDPKH. Complexes of[Co(HzPY)(2)]center dot 3.4H(2)O,[Zn(HzPY)(2)]and[Co(HpDPK)(2)]NO3 center dot H(2)Owere obtained. The crystal and the molecular structure of[Co(HzPY)(2)]center dot 3.4H(2)Owere determined using X-ray diffraction structure analysis. The compounds were characterized by elemental analysis, FT-IR and UV-Vis spectral data, conductivity and magnetic measurements, too. Except for the diamagnetic Co(III) compound with a nitrate counter-ion,[Co(HpDPK)(2)]NO3 center dot H2O, all the complexes are neutral-type. The magnetic moment of[Co(HzPY)(2)]center dot 3.4H(2)Oindicated a low-spin octahedral complex which is relatively rear amongst octahedral Co(II) complexes. Hence, its magnetic moment was measured in the temperature range of 3-300 K. To obtain products in the form of single crystals and/or to increase the yield, the reactions were carried out in solutions with different solvents or recrystallized from solvent mixtures. To determine the nature of the solvent (if any) in the crystalline products and to gain better insight into the decomposition mechanism, coupled TG-MS measurements were carried out. The desolvated compounds were stable at relatively high temperatures (> 200 degrees C). The cytotoxic, antiproliferative and efflux pump inhibitory effects of the compounds were tested in multidrug-resistant mouse T-lymphoma cells to study their effect on the suppression of MDR. The antibacterial activity of the compounds was also tested. The results of the antibacterial tests were analysed to understand better the effect of the central atoms and the structure on a specific activity.

Reference of 789-25-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 17852-52-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, SMILES is O=S(C1=CC=C(NN)C=C1)(N)=O.[H]Cl, belongs to phthalazine compound. In a article, author is Azab, Mohamed Emad, introduce new discover of the category.

The present work describes convenient synthesis of the novel Schiff bases 5a and b by reacting phthalazinones 4a and b with 4-methoxybenzaldehyde Reaction of the Schiff bases with phenylisothiocyanate afforded diazetidine derivatives 7a and b. Also, compounds 4a and b reacted with 2-bromoglucoside tetraacetate giving peracetylated N-glycosides 6a and b, which were deacetylated to afford N-glycosylated phthalazinones 8a and b. On the other hand, when compound 3 was treated with POCl3/PCl5 and/or ethyl chloroacetate, chlorophthalazine and ethyl acetate derivatives 9 and 10 were obtained, respectively. Hydrazinolysis of compounds 9 and 10 produced the hydrazino and hydrazide derivatives 11 and 12, respectively. When compound 11 reacted with 2-furanaldehyde, acetic anhydride, and/or carbon disulphide, it gave compounds 13-15, respectively. Treatment of the hydrazide 12 with aromatic aldehydes, acetic anhydride, ethyl acetoacetate, acetyl acetone, ammonium thiocyanate, and/or phthalic anhydride furnished compounds 17-21. Meanwhile, reacting Schiff base 22 with the chlorophthalazine derivative 9 produced compound 23, which on treatment with furoyl chloride produced compound 24. The structures of the novel compounds were confirmed by IR, H-1-NMR, C-13-NMR, MS, and elemental analysis. The newly synthesized compounds were tested against Bacillus subtilis and Staphylococcus aureus as Gram-positive bacteria, Escherichia coli and Pseudomonas aurignosa as Gram-negative bacteria, and Candida albicans and Aspergillus niger as fungi strains. Compounds 5a and b, 23, and 24 showed greater antimicrobial activity than the stranded compounds, suggesting that they could be considered as promising antimicrobial agents.

Application of 17852-52-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 17852-52-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 502496-34-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Zhao, Shanshan, introduce new discover of the category.

Poly (phthalazine ether sulfone ketone) (PPESK)/TiO2 organic-inorganic composite ultrafiltration (OF) membranes with enhanced performance for high temperature condensed water treatment were prepared using a phase-inversion method. The effects of TiO2 concentration on the membrane morphologies, physic-chemical properties, membrane permeability and antifouling performance were investigated and discussed. The SEM result reveals that the penetrated finger-like structure in sublayer is suppressed, and sponge-like structure begins to be developed. The mechanical strength and thermal stability of composite membrane are improved due to the existence of hydrogen bond between TiO2 and polymer. The permeate flux is also enlarged due to the improved hydrophilicity and porosity. Compared with neat PPESK membrane, the composite membranes present improved antifouling properties, showing lower filtration resistances, MEI values and better flux recover property during high temperature condensed water treatment. The optimal addition amount of TiO2 is 2 wt.%. The high temperature condensed water with excess oil and iron can be treated efficiently using PPESK/TiO2 composite membrane. The turbidity of feed solution is almost removed. The oil and iron concentrations in permeate solution are 0.89 mg/L and 26.4 mu g/L which meet the Quality Criterion of Water and Steam for Steam Power Equipment in China. (C) 2012 Elsevier B.V. All rights reserved.

Reference of 502496-34-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 502496-34-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.1008-72-6, Name is Sodium 2-formylbenzenesulfonate, SMILES is O=S(C1=CC=CC=C1C=O)([O-])=O.[Na+], belongs to phthalazine compound. In a document, author is Hoj, Martin, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/1008-72-6.html.

1-Azidophthalazine 9A is generated in trace amount by mild FVT of tetrazolo[5,1-a]phthalazine 9T and is observable by its absorption at 2121 cm(-1) in the Ar matrix IR spectrum. Ar matrix photolysis of 9T/9A at 254 nm causes ring opening to generate two conformers of (o-cyanophenyl)diazomethane 11 (2079 and 2075 cm(-1)), followed by (o-cyanophenyl)carbene (3)12, cyanocycloheptatetraene 13, and finally cyano(phenyl)carbene (3)14 as evaluated by IR spectroscopy. The two carbenes (3)12 and (3)14 were observed by ESR spectroscopy (D vertical bar hc = 0.5078, E vertical bar hc = 0.0236 and D vertical bar hc = 0.6488, E vertical bar hc = 0.0195 cm(-1), respectively). The rearrangement of 12 reversible arrow 13 reversible arrow 14 constitutes a carbene carbene-rearrangement. 1-Phthalazinylnitrene (3)10 is observed by means of its UV-vis spectrum in Ar matrix following FVT of 9 above 550 degrees C. Rearrangement to cyanophenylcarbenes also takes place on FVT of 9 as evidenced by observation of the products of ring contraction, viz., fulvenallenes and ethynylcyclopentadienes 16-18. Thus the overall rearrangement 10 -> 11 -> 12 reversible arrow 13 reversible arrow 14 can be formulated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1008-72-6 is helpful to your research. HPLC of Formula: https://www.ambeed.com/products/1008-72-6.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, formurla is C8H6BrF3. In a document, author is Mei, Yanbo, introducing its new discovery. Safety of 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

A simple synthesis of sodium 2-phosphanaphthalene-3-olate (1) based on the extrusion of N-2 from phthalazine using Na[OCP] is reported. This heterocycle can be readily functionalized at the negatively charged oxygen center using a variety of electrophilic substrates. The coordination chemistry of both 1 and its neutral derivatives was explored, revealing their facile use as P-donor ligands for late-transition-metal complexes.

If you are hungry for even more, make sure to check my other article about 402-49-3, Safety of 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 7524-50-7, Name is H-Phe-OMe.HCl, formurla is C10H14ClNO2. In a document, author is Zhu, Jie, introducing its new discovery. Recommanded Product: H-Phe-OMe.HCl.

A series of unprecedented binaphthyl-osmium nanoparticles (OsNPs) with chiral modifiers were applied in the heterogeneous asymmetric dihydroxylation of alkenes. A remarkable size effect of the OsNPs, depending on the density of the covalent organic shells, on the reactivity and enantioselectivity of the dihydroxylation reaction was revealed. Successful recycling of the OsNPs was also demonstrated and high reaction efficiency and enantioselectivity were maintained.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 7524-50-7 help many people in the next few years. Recommanded Product: H-Phe-OMe.HCl.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride. In a document, author is Shaterian, Hamid Reza, introducing its new discovery. Name: 4-Hydrazinylbenzenesulfonamide hydrochloride.

An efficient, one-pot quantitative procedure for preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives from four-component condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes in the presence of magnetic Fe3O4 nanoparticles coated by (3-aminopropyl)-triethoxysilane as catalyst under mild, ambient, and solvent-free conditions is described. Simple procedure, high yield, short reaction time, and environmentally benign method are advantages of this protocol. The magnetic Fe3O4 nanoparticles coated by (3-aminopropyl)-triethoxysilane can be recovered and reused several times without loss of activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 17852-52-7 help many people in the next few years. Name: 4-Hydrazinylbenzenesulfonamide hydrochloride.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 4271-30-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, belongs to phthalazine compound. In a article, author is Hameed, Alhamzah Dh., introduce new discover of the category.

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, H-1 NMR, C-13 NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31.

Synthetic Route of 4271-30-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 4271-30-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC=CC=C1C2=CC=CC=C2C(O)=O)O, belongs to phthalazine compound. In a document, author is Hameed, Alhamzah Dh., introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/482-05-3.html.

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, H-1 NMR, C-13 NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 482-05-3 is helpful to your research. HPLC of Formula: https://www.ambeed.com/products/482-05-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem