Tag: M.W:200-300

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1149-26-4, Name is Z-L-Val-OH, molecular formula is C13H17NO4. In an article, author is Amin, Kamilia M.,once mentioned of 1149-26-4, Product Details of 1149-26-4.

Efforts to develop new antitumor agents are now directed towards multitarget therapies that are believed to have high potency and low tendency to resistance compared to conventional drugs. Herein, we highlighted the synthesis and antitumor activity of five series of phthalazine-based compounds featuring a variety of bioactive chemical fragments at position 1 of the phthalazine nucleus. The antitumor activity of the target compounds was performed against fourteen cancer cell lines where all compounds were active in the nanomolar level. In addition, the mechanism of action of the target compounds was investigated through an enzymatic inhibitory assay against VEGFR-2 and EGFR kinases, revealing potent and preferential activity toward VEGFR-2. Binding mode of the most active compounds was studied using docking experiment. (C) 2016 Elsevier Masson SAS. All rights reserved.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl, Name: 1-(Bromomethyl)-4-chlorobenzene, belongs to phthalazine compound, is a common compound. In a patnet, author is Mohamadpour, Farzaneh, once mentioned the new application about 622-95-7.

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) as a highly efficient bicyclic amidine catalyst promoted one-pot multi-component synthesis of biologically active 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile under solvent-free conditions through simple filter with no necessity of chromatographic purification steps. Use of safe, non-volatile, non-corrosive, highly efficient, readily available and easy to handle of catalyst, one-pot reaction, high yields and short reaction times, economical and convenient synthesis, solvent-free conditions and operational simplicity are among the other added advantages that make this approach an attractive alternative for the synthesis of these biologically active compounds.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Computed Properties of https://www.ambeed.com/products/524-95-8.html, begins with the direct observation of nature— in this case, of matter.524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Bolteau, Raphael, introduce the new discover.

For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group as bioisosteric ligands analogues of previously developed Agomelatine. The biological activity of the prepared analogues was compared with that of Agomelatine. Quinazoline and phthalazine rings proved to be a versatile scaffold for easy feasible MT1 and MT2 ligands. Potent agonists with sub-micromolar binding affinity were obtained. However, the presence of two nitrogen atoms resulted in compounds with lower affinity for both MT1 and MT2, in comparison with the parent compound, balanced by the exhibition of good pharmacokinetic properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 524-95-8. Computed Properties of https://www.ambeed.com/products/524-95-8.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 102089-74-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 102089-74-7, Name is Boc-D-Phenylglycinol, SMILES is [C@@H](NC(OC(C)(C)C)=O)(C1=CC=CC=C1)CO, belongs to phthalazine compound. In a article, author is Thi Minh Ha Vuong, introduce new discover of the category.

Three new boron difluoride complexes based on phthalazine-pyridine, denoted (6), (7) and (8), have been synthesized and their photophysical and electrochemical properties have been studied. Solutions of these new BF2-complexes exhibit an intense blue fluorescence under UV light at low concentrations. Fluorescence quantum yields (QYs) have been determined by photoluminescence (PL) spectroscopy and decay times (tau) by semi-empirical methods. QYs of (6), (7) and (8) vary from 25% to 79%. HOMO and LUMO energy levels have been estimated by cyclic voltammetry and PL spectroscopy. The HOMO and LUMO energy levels, at similar to -5.3 eV and similar to -2.3 eV, respectively, make these new complexes interesting candidates as blue emitters in OLED applications.

Electric Literature of 102089-74-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 102089-74-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, begins with the direct observation of nature— in this case, of matter.201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, SMILES is CC(SC(C1=CC=CC=C1)=S)(C#N)CCC(O)=O, belongs to phthalazine compound. In a document, author is Bai, Li-Gang, introduce the new discover.

Potassium tert-butoxide-promoted aerobic oxidation of N-alkyl iminium salts is reported. The reaction is atom-economical and environmentally friendly. Iminium salts derived from isoquinoline, quinoline, phenanthridine, phenanthroline, and phthalazine were successfully transformed into their corresponding unsaturated lactams with up to 95% yield under mild conditions in the absence of photocatalysts and metallic or organic catalysts. Owing to the general substrate scope, low cost, feasibility of scale up, wide availability of reagents, and green reaction conditions, this method shows great potential for preparing isoquinolones and related compounds. The method was applied for atom- and step-economical total synthesis of natural products such as norketoyobyrine.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 482-05-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC=CC=C1C2=CC=CC=C2C(O)=O)O, belongs to phthalazine compound. In a article, author is Tuerkmen, Yunus E., introduce new discover of the category.

A highly effective silver-catalyzed formal inverse electron-demand Diets Alder reaction of 1,2-diazines and siloxy alkynes has been developed. The reactions provide ready access to a wide range of siloxy naphthalenes and anthracenes, which are formed in good to high yields, under mild reaction conditions, using low catalyst loadings.

Electric Literature of 482-05-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 482-05-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, belongs to phthalazine compound. In a document, author is Mantu, Dorina, introduce the new discover, Category: phthalazines.

The synthesis, structure, and in vitro anticancer activity of a new class of anticancer derivatives with dihydrobenzo[5,6]isoindolo[1,2-a]phthalazine and dihydrobenzo[f]pyridazino[6,1-a]isoindole skeletons are presented. The preparation is straight and efficient, involving two steps only: a N-alkylation of the pyridazine or phthalazine heterocycle, followed by a [3 + 2] dipolar cycloaddition of 1,2-diazinium ylides to the corresponding dipolarophiles. The synthesis was performed under microwave and ultrasound (US) irradiation as well as under conventional thermal heating. The most effective conditions in term of yields and time were found to be US irradiation. The penta- and tetra-cyclic 1,2-diazines were evaluated for their in vitro anticancer activity. The pentacyclic 1,2-diazine derivatives exhibit a significant anticancer activity against Non-Small Cell Lung Cancer NCI-H460, Leukemia MOLT-4, Leukemia CCRF-CEM, and Breast Cancer MCF7. A feasible explanation for anticancer efficiency of the pentacyclic 1,2-diazines have been furnished, being correlated with the mechanisms of action. The synthesis (conventional thermal heating, microwave and ultrasound irradiation), structure, and in vitro anticancer activity of a new class of anticancer molecules with polycyclic 1,2-diazines skeleton is presented.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 54381-16-7. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

1878-68-8, Name is 4-Bromophenylacetic acid, molecular formula is C8H7BrO2, COA of Formula: https://www.ambeed.com/products/1878-68-8.html, belongs to phthalazine compound, is a common compound. In a patnet, author is Zaheer, Zahid, once mentioned the new application about 1878-68-8.

A facile and highly efficient one-pot synthesis of phthalazine-quinoline derivatives is reported via four component reaction of phthalic anhydride, hydrazine hydrate, 5,5-dimethyl 1,3 cyclohexanedione and various quinoline aldehydes using PrxCoFe(2-x)O(4) (x = 0.1) nanoparticles as a catalyst. The synthesized compounds have been evaluated for anti-biofilm activity against Pseudomonas aeruginosa and Candida albicans. The compounds 12a (IC50 = 30.0 mu M) and 12f (IC50 = 34.5 mu M) had shown promising anti-biofilm activity against P. aeruginosa and C. albicans, respectively, when compared with standards without affecting the growth of cells (and thus behave as anti-quorum sensing agents). Compounds 12a (MIC = 45.0 mu g/mL) and 12f (MIC = 57.5 mu g/mL) showed significant potent antimicrobial activity against P. aeruginosa and C. albicans, respectively. Thus, the active derivatives were not only potent biofilm inhibitors but also efficient antimicrobial agents. In silico ADME and metabolic site prediction studies were also held out to set an effective lead candidate for the future antimicrobial drug discovery initiatives. (C) 2016 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazine compound. In a document, author is Khalil, Nadia A., introduce the new discover, Category: phthalazines.

Novel 4-(4-bromophenyl)phthalazine derivatives connected via an alkyl spacer to amine or N-substituted piperazine were designed and synthesized as promising alpha-adrenoceptor antagonists. The structures of the phthalazine derivatives were established using elemental and spectral analyses. Twelve of the tested compounds displayed significant alpha-blocking activity. Molecular modeling studies were performed to rationalize the biological results. Among the tested compounds, 7j displayed the best-fitting score and the highest in vitro activity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 81-16-3 is helpful to your research. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Mei, Yanbo, once mentioned the application of 93-28-7, Safety of Eugenol Acetate, Name is Eugenol Acetate, molecular formula is C12H14O3, molecular weight is 206.24, MDL number is MFCD00026191, category is phthalazine. Now introduce a scientific discovery about this category.

A simple synthesis of sodium 2-phosphanaphthalene-3-olate (1) based on the extrusion of N-2 from phthalazine using Na[OCP] is reported. This heterocycle can be readily functionalized at the negatively charged oxygen center using a variety of electrophilic substrates. The coordination chemistry of both 1 and its neutral derivatives was explored, revealing their facile use as P-donor ligands for late-transition-metal complexes.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem