Tag: M.W:200-300

Related Products of 201611-92-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, SMILES is CC(SC(C1=CC=CC=C1)=S)(C#N)CCC(O)=O, belongs to phthalazine compound. In a article, author is Azarifar, Davood, introduce new discover of the category.

Tetrakis(acetonitrile)copper(I) Hexafluorophosphate as an Efficient Catalyst for the Synthesis of Triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione Derivatives

Tetrakis(acetonitrile) copper(I) hexafluorophosphate, [Cu(CH3CN)(4)]PF6, was explored as an efficient catalyst to promote the three-component reaction of aryl aldehydes, dimedone and urazole or phthalhydrazide to afford the corresponding triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione derivatives respectively in high yields. The reactions were conducted at 80-100 degrees C under solvent-free conditions. The catalyst was easily prepared from available and inexpensive materials and was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity.

Related Products of 201611-92-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 201611-92-9.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. HPLC of Formula: C18H16Si, 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, in an article , author is Wan, Yu, once mentioned of 789-25-3.

Regioselective Synthesis of Amino Substituted Indazolo[2,1-b]phthalazine-triones and Pyrazolo[1,2-b]phthalazine-2-carbonitriles Catalyzed by 2-1-Methylimidazolium-3-yl-1-ethyl Sulfate

The regioselective reactions of luminol with 1,3-cyclohexanedione (or malononitrile) and aromatic aldehydes catalyzed by 2-1-methylimidazolium-3-yl-1-ethyl sulfate were developed to synthesize 7-amino-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones and 3,9-diamino-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitriles in good to excellent yields in short times.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 789-25-3, you can contact me at any time and look forward to more communication. HPLC of Formula: C18H16Si.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C14H12O2, 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Chate, Asha V., introduce the new discover.

beta-Cyclodextrin as a supramolecular catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives in water and their antimicrobial activities

An efficient and green method has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazinetriones derivatives by employing 15 mol% beta-cyclodextrinvia a one-pot multicomponent reaction of aldehyde, dimedone, hydrazine hydrate with succinic anhydrideiphthalic anhydride in water at 80 degrees C for first time. The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains. The outcome of the screening study showed that compound 6d, 6f and 7n exhibited excellent activity against E. coil. Whereas, compound 6f and 6 h exhibited excellent activity against P. aeurginosa, and compound 6c, and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S. aureus and B. subtilis when compared with Ampicillin (standard control). The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 117-34-0 is helpful to your research. HPLC of Formula: C14H12O2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Safety of Eugenol Acetate, 93-28-7, Name is Eugenol Acetate, SMILES is CC(OC1=CC=C(CC=C)C=C1OC)=O, in an article , author is Imran, Mohd, once mentioned of 93-28-7.

Study of Various Pyridazine and Phthalazine Drugs with Diverse Therapeutical and Agrochemical Activities

Pyridazines hold considerable interest relative to pharmacologically active molecules. The pyridazine compounds are exhibited different types of pharmacological activities. The various pyridazine drugs are shown phosphodiestrase (PDE) inhibitor, positive inotropic, vasodilation, analgesic, antiiflamatory, antimicrobial, antidepressant, antipsychotic, antianxiety, antifeeedant, herbicidal, insecticidal, plant growth regulatory, molluscicidal and other biological and agrochemical activities. Pyridazine derivatives focused consideration because of their effortless fuctionalization at various ring positions, which creates them striking compounds for designing and progress of the new pyridazine drugs in future.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 93-28-7, you can contact me at any time and look forward to more communication. Safety of Eugenol Acetate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, molecular formula is C13H12O3, belongs to phthalazine compound, is a common compound. In a patnet, author is Imran, Mohd, once mentioned the new application about 23981-47-7, Product Details of 23981-47-7.

Study of Various Pyridazine and Phthalazine Drugs with Diverse Therapeutical and Agrochemical Activities

Pyridazines hold considerable interest relative to pharmacologically active molecules. The pyridazine compounds are exhibited different types of pharmacological activities. The various pyridazine drugs are shown phosphodiestrase (PDE) inhibitor, positive inotropic, vasodilation, analgesic, antiiflamatory, antimicrobial, antidepressant, antipsychotic, antianxiety, antifeeedant, herbicidal, insecticidal, plant growth regulatory, molluscicidal and other biological and agrochemical activities. Pyridazine derivatives focused consideration because of their effortless fuctionalization at various ring positions, which creates them striking compounds for designing and progress of the new pyridazine drugs in future.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 23981-47-7. The above is the message from the blog manager. Product Details of 23981-47-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a document, author is Taslimi, Parham, introduce the new discover, Recommanded Product: 502496-34-6.

Cholinesterases, alpha-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer’s disease and diabetes mellitus

In this study, using the Cu(OTf)(2) catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzymes with K-i values in the range of 4.88-15.94 nM for hCA I, 7.04-20.83 nM for hCA II, 68.25-158.27 for AChE, 60.17-91.27 for BChE and 0.36-2.36 nM for alpha-Gly, respectively. In silico studies were performed on the molecules inhibiting hCA I, hCA II, AChE, BChE and alpha-Gly receptors. When we evaluated the data obtained in this work, we determined the inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors. Reference inhibitors were used for all enzymes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 502496-34-6 is helpful to your research. Recommanded Product: 502496-34-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.108-36-1, Name is 1,3-Dibromobenzene, SMILES is BrC1=CC(Br)=CC=C1, belongs to phthalazine compound. In a document, author is Salehi, Peyman, introduce the new discover, COA of Formula: C6H4Br2.

Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 108-36-1 is helpful to your research. COA of Formula: C6H4Br2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 789-25-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazine compound. In a article, author is Patil, Smita, introduce new discover of the category.

Highly Sensitive Ratiometric Chemosensor for Selective ‘Naked-Eye’ Nanomolar Detection of Co2+ in Semi-Aqueous Media

An easy-to-prepare chemosensor, (E)-1-(phthalazine-4-yl)-2-(1-(pyridine-2-yl)ethylidene) hydrazine (3), structurally characterized by single X-ray crystallography, is developed for the selective and sensitive detection of Co2+ in aqueous media. Chemosensor 3 shows both absorption and fluorescence responses to Co2+ by forming a 1: 1 complex (among the surveyed metal ions) with a detection limit down to 50 nm. It can also be used as a ‘naked-eye’ sensor due to the outstanding visible and emission color changes from yellow to red and blue to orange, respectively.

Related Products of 789-25-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 2,2-Diphenylacetic acid, 117-34-0, Name is 2,2-Diphenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)C2=CC=CC=C2, in an article , author is Wang, Haitao, once mentioned of 117-34-0.

Enantioselective Fluorocyclizations Mediated by Amino-Acid-Derived Phthalazine

Novel amino-acid-derived phthalazine reagents have been designed and synthesized for the enantioselective fluorocyclizations of prochiral indoles. The scope of reaction is evidenced by 28 examples of fluorinated furoindole and pyrroloindole heterocycles bearing various functionalities with up to 99% ee. The resulting enantioenriched fluorinated products are found to be potent AChE inhibitors. Advantages of the current new chiral reagents include ease in the synthesis of analogues and readily tunable steric/electronic demands.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 117-34-0, you can contact me at any time and look forward to more communication. Recommanded Product: 2,2-Diphenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H10O4, Safety of [1,1′-Biphenyl]-2,2′-dicarboxylic acid, belongs to phthalazine compound, is a common compound. In a patnet, author is Eldehna, Wagdy M., once mentioned the new application about 482-05-3.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl) phthalazine derivatives

A series of anilinophthalazine derivatives 4a-j was initially synthesized and tested for its VEGFR-2 inhibitory activity where it showed promising activity (IC50 = 0.636-5.76 mu M). Molecular docking studies guidance was used to improve the binding affinity for series 4a-j towards VEGFR-2 active site. This improvement was achieved by increasing the hydrophobic interaction with the hydrophobic back pocket of the VEGFR-2 active site lined with the hydrophobic side chains of Ile888, Leu889, Ile892, Val898, Val899, Leu1019 and Ile1044. Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into the hydrophobic back pocket. As planned, the designed uriedo-anilinophthalazines 7a-i showed superior binding affinity than their anilinophthalazine parents (IC50 = 0.083-0.473 mu M). In particular, compounds 7g-i showed IC50 of 0.086, 0.083 and 0.086 mu M, respectively, which are better than that of the reference drug sorafenib (IC50 = 0.09 mu M). (C) 2016 Elsevier Masson SAS. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 482-05-3 help many people in the next few years. Safety of [1,1′-Biphenyl]-2,2′-dicarboxylic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem