Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Name: 2,2-Dimethoxy-2-phenylacetophenone, 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, SMILES is COC(OC)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1, in an article , author is Mirahmadpour, Pari, once mentioned of 24650-42-8.

Electrochemical Oxidation of 2,3-dihydrophthalazine-1,4-dione in the Presence of Indole Derivatives

The electrochemical oxidation of 2,3-dihydrophthalazine-1,4-dione (1) has been studied in the presence of indole derivatives as nucleophiles in a water/acetonitrile mixture by means of cyclic voltammetry and controlled-potential coulometry. Results indicate that electrogenerated phthalazine-1,4-dione (1ox) participates in a Michael type addition reaction with indole derivatives (2 and 3) via an EC mechanism. In this work, we propose a mechanism for the electrode process. The electrochemical synthesis of indoylphthalazines (4 and 5) has been successfully performed at a carbon rod electrode and in an undivided cell. (C) 2013 The Electrochemical Society. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 24650-42-8, you can contact me at any time and look forward to more communication. Name: 2,2-Dimethoxy-2-phenylacetophenone.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 524-95-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a article, author is Xue, Deng-Qi, introduce new discover of the category.

Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives

Trying to develop potent and selective anticancer agents, two series of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives were designed and synthesized. Their antitumor activities were evaluated by MU method against four selected human cancer cell lines (MGC-803, EC-9706, HeLa and MCF-7). Our results showed that compound 11h exhibited good anticancer activities compared to 5-fluorouracil against the four tested cell lines, with IC50 values ranging from 2.0 to 4.5 mu M. Flow cytometry analysis indicated that compound 11h induced the cellular early apoptosis and cell cycle arrest at G2/M phase in EC-9706. (C) 2014 Published by Elsevier Masson SAS.

Synthetic Route of 524-95-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 524-95-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, SMILES is CC(SC(C1=CC=CC=C1)=S)(C#N)CCC(O)=O, in an article , author is Shyma, P. C., once mentioned of 201611-92-9, COA of Formula: C13H13NO2S2.

Regioselective one pot synthesis of 1,2,3-triazole derivatives bearing phthalazine moiety and their pharmacological activity

A new series of phthalazine-based 1,2,3-triazole derivatives (5a-h, 6a-f and 7a-d) were synthesized from the corresponding 2-(4-methyl/chloro benzyloxy) benzoic acid by multi-step reactions. Synthesized compounds were characterized by spectral studies and C, H, N analysis. The final compounds were screened for their antimicrobial, antifungal and antioxidant activity. Among them compounds 5c, 5g, 5h, 6b and 6e showed good antibacterial activity as compared to the standard drug streptomycin,whereas compounds 5g and 6d showed good antifungal activity comparable to the standard drug Fluconazole. Compounds 5a, 5f and 7c showed significant antioxidant property when compared with the standard butylated hydroxytoluene.

Interested yet? Read on for other articles about 201611-92-9, you can contact me at any time and look forward to more communication. COA of Formula: C13H13NO2S2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Sangani, Chetan B., introduce the new discover, Computed Properties of C14H16BNO.

Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: assessment of their antimicrobial, antituberculosis and antioxidant activity

A new series of pyrazolo[1,2-b]phthalazine derivatives (4a-p) bearing the 5-aryloxypyrazole nucleus was synthesized by one-pot, three-component, base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), malononitrile or ethyl cyanoacetate (2a-b) and 2,3-dihydro-1,4-phthalazinedione (3a-b) in ethanol containing an eco friendly base, NaOH, in good to excellent yields. All synthesized compounds (4a-p) were duly characterized by physico-chemical parameters, H-1 NMR, C-13 NMR, FT-IR and LCMS techniques. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 4e, 4g, 4h, 4k and 4o exhibited excellent antimicrobial activity compared with first line drugs. In vitro antituberculosis activity was evaluated against Mycobacterium tuberculosis H37Rv, and compounds 4g and 4o emerged as the promising antimicrobial members with better antituberculosis activity. A brine shrimp bioassay was carried out to study the in vitro cytotoxic properties of the synthesized compounds. In vitro antioxidant activity was evaluated by the ferric-reducing antioxidant power method. Compounds 4c, 4d, 4g and 4h showed the highest antioxidant potencies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 524-95-8 is helpful to your research. Computed Properties of C14H16BNO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1878-68-8, Name is 4-Bromophenylacetic acid, SMILES is OC(=O)CC1=CC=C(Br)C=C1, in an article , author is Selvaraj, Keerthana, once mentioned of 1878-68-8, Product Details of 1878-68-8.

Tel-Cu-NPs Catalyst: Synthesis of Naphtho[2,3-g]phthalazine Derivatives as Potential Inhibiters of Tyrosinase Enzymes and Their Investigation in Kinetic, Molecular Docking, and Cytotoxicity Studies

Novel one-pot synthesis naphtho[2,3-g]phthalazine (1a-1k) of Mannich base derivatives can be achieved via grindstone chemistry using a Tel-Cu-NPs (telmisartan-copper nanoparticles) catalyst. This method offers efficient mild reaction conditions and high yields. Tyrosinase inhibitory activity was evaluated for all synthesized compounds, along with analysis of kinetic behavior and molecular docking studies. The synthesized compound, 1c was (IC50 = 11.5 mu M) more active than kojic acid (IC50 = 78.0 mu M). Lineweaver Burk plots were used to analyze the kinetic behavior of the most active compound 1c, it was reversible and competitive behavior. Compound 1c and kojic acid occurred in the presence of 2-hydroxyketone, which has the same inhibitory mechanism. The molecular docking of compound 1c and the control kojic acid were docked against 2Y9X protein via the Schrodinger Suite. The compound 1c showed a respectable dock score (-5.6 kcal/mol) compared to kojic acid with a dock score of (-5.2 kcal/mol) in the 2Y9X protein. Cytotoxicity activity was also evaluated by using HepG2 (liver), MCF-7 (breast), and HeLa (cervical) cancer cell lines, and high activity for 1c (GI(50) = 0.01, 0.03, and 0.04 mu M, respectively) against all cell lines was found compared to standard and other compounds. Therefore, this study succeeded in testing a few promising molecules as potential antityrosinase agents.

Interested yet? Read on for other articles about 1878-68-8, you can contact me at any time and look forward to more communication. Product Details of 1878-68-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Safety of 4,4′-Methylenebis(2-methylaniline), begins with the direct observation of nature— in this case, of matter.838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), SMILES is NC1=CC=C(CC2=CC=C(C(C)=C2)N)C=C1C, belongs to phthalazine compound. In a document, author is Vafaee, Asieh, introduce the new discover.

An Efficient and High-yielding One-pot Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sodium Hydrogen Carbonate under Solvent-free Conditions

Sodium hydrogen carbonate, NaHCO3, efficiently catalyzes the one-pot, three-component reaction of phthalhydrazide, an aromatic aldehyde, and malononitrile or ethyl cyanoacetate under solvent-free conditions, to afford the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in high yields. Easy work up, inexpensive and readily available catalyst and avoiding the use of harmful organic solvents are other advantages of this simple procedure.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 838-88-0. Safety of 4,4′-Methylenebis(2-methylaniline).

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 108-36-1, Name is 1,3-Dibromobenzene. In a document, author is Wang, Yan-Ning, introducing its new discovery. SDS of cas: 108-36-1.

New in situ generated acylhydrazidate-coordinated complexes and acylhydrazide molecules: Synthesis, structural characterization and photoluminescence property

By utilizing the hydrothermal in situ acylation of organic acids with N2H4, three acylhydrazidate-coordinated compounds [mn(L1)(2)(H2O)(2)] (L1 = 2,3-quinolinedicarboxylhydrazidate; HL1 = 2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione) 1, [Mn-2(ox)(L-2)(2)(H2O)(6)]center dot 2H(2)O (L2 = benzimidazolate-5,6-dicarboxylhydrazide; HL2 = 6,7-dihydro-1H-imidazo[4,5-g]phthalazine-5,8-dione; ox = oxalate) 2, and [Cd(HL3)(bpy)] (L3 = 4,5-di(3′-carboxylphenyl)phthalhydrazidate; H(3)L3 = 6,7-dihydro-1H-imidazo[4,5-g]phthalazine-5,8-dione; bpy = 2,2′-bipyridine) 3, as well as two acylhydrazide molecules L4 (L4 = oxepino[2,3,4-de:7,6,5-d’e’]diphthalazine-4, 10(5H,9H)-dione) 4 and L5 (L5 = 4,5-dibromophthalhydrazide; L5 = 6,7-dibromo-2,3-dihydrophthalazine-1, 4-dione) 5 were obtained. X-ray single-crystal diffraction analysis reveals that (i) I only possesses a mononuclear structure, but it self-assembles into a 2-D supramolecular network via the N-hydrazine-H center dot center dot center dot N-hydrazine and Ow-H center dot center dot center dot O-hydroxylimino interactions; (ii) 2 exhibits a dinuclear structure. Ox acts as the linker, while L2 just serves as a terminal ligand; (iii) In 3,13 acts as a 3-connected node to propagate the 7-coordinated Cd2+ centers into a 1-D double-chain structure; (iv) 4 is a special acylhydrazide molecule. Two-OH groups for the intermediates 3,3′-biphthalhydrazide further lose one water molecule to form 4; (v) 5 is a common monoacylhydrazide molecule. Via the N-hydrazine-H center dot center dot center dot O-hydrazine, O-hydroxylimino-H center dot center dot center dot O-acylamino and the pi center dot center dot center dot pi interactions, it self-assembles into a 2-D supramolecular network. The photoluminescence analysis reveals that 4 emits light with the maxima at 510 nm. (C) 2016 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 108-36-1 help many people in the next few years. SDS of cas: 108-36-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 4-Hydrazinylbenzenesulfonamide hydrochloride, 17852-52-7, Name is 4-Hydrazinylbenzenesulfonamide hydrochloride, molecular formula is C6H10ClN3O2S, belongs to phthalazine compound. In a document, author is Hosseininasab, Nasrinsadat, introduce the new discover.

Synthesis of New Pyrimido[4,5:3,4]pyrazolo[1,2-b]phthalazine-4,7,12-triones: Derivatives of a New Heterocyclic Ring System

Several derivatives of the new pyrimido[4,5:3,4]pyrazolo[1,2-b]phthalazine-4,7,12-trione ring system have been prepared by the reaction of 3-amino-1-aryl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-2-carbonitriles with aliphatic carboxylic acids in the presence of phosphoryl chloride (POCl3). The synthesized compounds were characterized on the basis of IR, H-1 NMR, and C-13 NMR spectral and microanalytical data.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 17852-52-7. Recommanded Product: 4-Hydrazinylbenzenesulfonamide hydrochloride.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 618-88-2, Name is 5-Nitroisophthalic acid, molecular formula is C8H5NO6, belongs to phthalazine compound, is a common compound. In a patnet, author is Maheshwari, D. P. Loka, once mentioned the new application about 618-88-2, SDS of cas: 618-88-2.

ONE-POT SYNTHESES OF 1H-PYRAZOLO[1,2-B]PHTHALAZINE-5,10-DIONES IN MOLTEN TBAB

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) have been achieved from phthaloyl dichloride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) or ethyl cynoacetate (4b) in molten Tetrabutylammonium Bromide as medium at 100-105 degrees C for 20-30 min by in-situ generation of HCl as a catalyst. These reactions have an easy workup, provide excellent yields, and use TBAB as the reaction medium.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 618-88-2. The above is the message from the blog manager. SDS of cas: 618-88-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 102089-74-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 102089-74-7, Name is Boc-D-Phenylglycinol, SMILES is [C@@H](NC(OC(C)(C)C)=O)(C1=CC=CC=C1)CO, belongs to phthalazine compound. In a article, author is Mosaddegh, Elaheh, introduce new discover of the category.

Preparation, characterization, and catalytic activity of Ca2CuO3/CaCu2O3/CaO nanocomposite as a novel and bio-derived mixed metal oxide catalyst in the green synthesis of 2H-indazolo[2,1-b]phthalazine-triones

As a novel and heterogeneous catalyst, the Ca2CuO3/CaCu2O3/CaO nanocomposite was synthesized via coprecipitation and thermal decomposition methods using CuSO4 and eggshell wastes as inexpensive starting materials. The catalytic activity of the mesoporous mixed metal oxide in the synthesis of 2H-indazolo[2,1-b]phthalazine-triones was investigated. The reaction proceeds to completion within 5-20 min with yields of 80-94%. The suggested strategy for synthesizing 2H-indazolo[2,1-b]phthalazine-triones is of great interest because a novel, green, and low-cost mixed metal oxide is used as a heterogeneous catalyst, on account of its convenient preparation, short reaction time, and high reusability without any loss of catalytic activity. (C) 2015 Elsevier B.V. All rights reserved.

Electric Literature of 102089-74-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 102089-74-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem