Tag: M.W:300-400

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3, belongs to phthalazine compound, is a common compound. In a patnet, author is Hiremath, Prashant B., once mentioned the new application about 81-48-1, Application In Synthesis of 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.

An efficient and rapid one-pot multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones through condensation of aldehyde, malononitrile and phthalhydrazide catalyzed by agro-waste solvent catalyst-derived water extract of mango peel ash (WEMPA) under microwave irradiation is described. Further, the catalyst is prepared from agricultural waste and characterized for elemental composition by different techniques such as SEM-EDX, XRD and flame photometry. This green synthetic approach offers various advantages such as inexpensive, abundantly available source, shorter reaction time (6-8 min), good-to-excellent yield (83%-89%), simple workup and a sustainable alternative method to the existing protocols. All the synthesized compounds (4a-l) was confirmed by FT-IR,H-1-NMR,C-13-NMR and LC-MS.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 81-48-1. The above is the message from the blog manager. Application In Synthesis of 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, molecular formula is C21H19OP. In an article, author is Cabeza, Javier A.,once mentioned of 1439-36-7, Quality Control of 1-(Triphenylphosphoranylidene)propan-2-one.

The reactions of [Ru-3(CO)(12)] with four aromatic diazines have been studied in THF at reflux temperature. With phthalazine (L-1), the compound [Ru-3(mu-kappa(NN3)-N-2-N-2-L-1)(mu-CO)(3)(CO)(7)] (1), which contains an intact phthalazine ligand in an axial position bridging an Ru-Ru edge through both N atoms, is initially formed but it reacts with more phthalazine to give [Ru-3(kappa N-2-L-1)(mu-kappa(NN3)-N-2-N-2-L-1)(mu-CO)(3)(CO)(6)] (2), in which a pi-pi stacking interaction between the aromatic rings of both ligands determines their position in cluster axial sites on the same face of the Ru3 triangle. With quinazoline (HL2), the cyclometalated hydrido decacarbonyl derivative [Ru-3(mu-H)(mu-kappa(NC4)-N-2-C-3-L-2)(CO)(10)] (3) is initially produced but it partially decarbonylates under the reaction conditions to give [Ru-6(mu-H)(2)(mu-kappa(NC4)-N-2-C-3-L-2)(mu(3)-kappa(3)-(NNC4)-N-1-C-3-L-2)(CO)(19)] (4), which results from the displacement of a CO ligand of 3 by the uncoordinated N-1 atom of another molecule of 3. With 4,7-phenanthroline (H2L3), the stepwise formation of the cyclometalated derivatives [Ru-3(mu-H)(mu-kappa(NC3)-N-2-C-4-HL3)(CO)(10)] (5) and two isomers of [Ru-6(mu-H)(2)(mu(4)-kappa(NCNC8)-N-4-C-4-N-3-C-7-L-3)(CO)(20)] (6a, 6b) takes place. In compounds 6a and 6b, two Ru-3(mu-H)(CO)(10) trinuclear units are symmetrically (C-2 in 6a or C-S in 6b) bridged by a doubly-cyclometalated 4,7-phenanthroline ligand. With 2,3′-bipyridine (HL4), two products have been isolated, [Ru-3(mu-H)(mu-kappa N-2(3)’ C-4′-L-4)(CO)(10)] (7) and [Ru-3(mu-H)-(mu-kappa(NN3)-N-3-N-2’C-2′-L-4)(CO)(9)] (8). While compound 7 contains an N-3′ C-4′-cyclometalated 2,3′-bipyridine, in compound 8 an N-3′ C-2′-cyclometalation is accompanied by the coordination of the N-2 atom of the remaining pyridine fragment. The structures of compounds 2, 3, 4, 6a and 8 have been determined by X-ray diffraction crystallography.

Interested yet? Keep reading other articles of 1439-36-7, you can contact me at any time and look forward to more communication. Quality Control of 1-(Triphenylphosphoranylidene)propan-2-one.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 1439-36-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a article, author is Akabane, Takafumi, introduce new discover of the category.

Human hepatocytes are a physiologically relevant tool useful in evaluating liver-related pharmacokinetics, including non-cytochrome P-450 (CYP) metabolism, due to their broad spectrum of metabolic enzyme activity. To verify the usefulness of human hepatocytes in evaluating non-CYP metabolism for drug discovery, we compared intrinsic clearance values (CLint) in freshly isolated and cryopreserved hepatocytes using 14 compounds primarily metabolized by non-CYP enzymes, including UDP-glucuronosyltransferase, carbonyl/aldo-keto reductase, aldehyde oxidase, flavin-containing monooxygenase, and monoamineoxidase. Cryopreservation resulted in a > 20% reduction (maximum: 50%) in CLint in 7/14 compounds (statistically significant for 5 compounds) on comparing CLint values in freshly isolated and cryopreserved hepatocytes from the same donors (n = 4). However, the number of compounds with > 20% CLint reduction decreased to 3 on comparing average of CLint values including un-matched donors (dolasetron: -27%, naltorexone: -32%, and phthalazine: -48%; statistically significant for phthalazine, n = 6-11). These findings suggest that fresh hepatocytes are useful in evaluating intact non-CYP enzyme activities. However, we must note that the reduction in CLint by cryopreservation could be rendered negligible if high-activity lots are selected for assay. We therefore recommend using cryopreserved hepatocytes for large-scale screening for non-CYP metabolism in drug discovery research considering the advantages in usability with cryopreserved hepatocytes.

Electric Literature of 1439-36-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1439-36-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn, HPLC of Formula: https://www.ambeed.com/products/523-27-3.html, Especially from a beginner’s point of view. Like 523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is phthalazine, belongs to phthalazine compound. In a document, author is El-Helby, Abdel-Ghany A., introducing its new discovery.

In view of the anticonvulsant activity reported for phthalazine derivatives as non-competitive AMPA receptor antagonists, a new series of phthalazine-1,4-diones (2-12) were designed and synthesized. The neurotoxicity was assessed using rotarod test. The molecular docking was performed for the synthesized compounds to assess their binding affinities toward AMPA receptor as non-competitive antagonists. The molecular modeling data were strongly interrelated to biological screening data. Compounds 8, 7(b), 7(a), 10 and 3(a) exhibited the highest binding affinities as non-competitive AMPA receptor antagonists and also showed the highest relative potencies of 1.78, 1.66, 1.60, 1.59 and 1.29, respectively, as anticonvulsants in comparison with diazepam. The most active compounds 8, 7(b), 7(a), 10 and 3(a) were further tested against maximal electroshock seizure (MES). Compounds 8 and 7(b) and 3(a) showed 100% protection at a dose level of 125 mu gm/kg, while compounds 7(a) and 10 exhibited 83.33% protection at the same dose level. These agents exerted low neurotoxicity and high safety margin in comparison with valproate as a reference drug. Most of our designed compounds exhibited good ADMET profile.

If you are hungry for even more, make sure to check my other article about 523-27-3, HPLC of Formula: https://www.ambeed.com/products/523-27-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 35661-39-3, Name is Fmoc-Ala-OH, SMILES is C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, in an article , author is Chavan, Laxmikant D., once mentioned of 35661-39-3, COA of Formula: https://www.ambeed.com/products/35661-39-3.html.

A series of 11-molybdo-1-vanadophosphoric acid supported on montmorillonite K-10 catalysts were prepared and characterized by FT-IR spectroscopy, thermal analysis, XRD, BET and SEM analysis techniques. Characterization data reveals the chemical immobilization of H4PMo11V1O40 catalyst on the montmorillonite K-10 support. The catalytic performance of synthesized catalysts was investigated for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives by one-pot three-component reaction of phthalhydrazide, dimedone and aromatic aldehydes under solvent-free conditions. Among different catalysts, 20% H4PMo11V1O40 supported on to montmorillonite K-10 showed the highest catalytic activity. Effect of reaction parameters such as catalyst loading, temperature and the nature of substituents on the aromatic ring of aldehydes were also evaluated. The protocol developed using H4PMo11V1O40/K-10 has several distinct advantages such as operational simplicity, short reaction time, high yield, reusable catalyst and preclusion of toxic solvent.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 35661-39-3, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/35661-39-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 14348-75-5, Name is 2,7-Dibromo-9H-fluoren-9-one, SMILES is C3=C2C1=C(C=C(Br)C=C1)C(C2=CC(=C3)Br)=O, belongs to phthalazine compound. In a document, author is Saundane, Anand R., introduce the new discover, Computed Properties of https://www.ambeed.com/products/14348-75-5.html.

A new series of novel compounds 1-tert-butyl-9-substituted-12H-indolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazoles (4a-4c), 10-substituted-2-phenyl-1,13-dihydroindolo[2,3-c]isoquinolino[5,6-c]-1,2,4-triazines (5a-5l), 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)-4-phenylphthalazin-1-ones (6a-6c), 2-[2-(10-substituted-7H-indolo[2,3-c]isoquinolinyl)hydrazinecarbonyl]benzoic acid (7a-7c), and 2-(10-substituted-7H-indolo[2,3-c]isoquinolin-5-yl)phthalazine-1,4-diones (8a-8c) were synthesized. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial, antitubercular, antioxidant, and cytotoxic activities. Compounds 4b, 5a, 5g, 5h, 6a, 6b, and 7b exhibited the maximum zone of inhibition against Staphylococcus aureus. Compounds 5d and 6c exhibited the maximum zone of inhibition against Pseudomonas aeruginosa. Compounds 7a and 8c showed maximum zone of inhibition against Aspergillus niger. Compounds 5k and 8c showed maximum zone of inhibition against Aspergillus flavus. Compounds 4a (MIC-1.6 A mu g/ml) and 5 h (MIC-0.2 A mu g/ml) exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds 4b, 4c, 5a, 5c, 5e, 5h, 6a, 6b, 6c, 8a, and 8b exhibited good radical scavenging activity compared with standards. Compounds 4b, 4c, 5a, 5c, 5g, 6a, and 8b exhibited maximum reducing ability. Compounds 4a and 5h exhibited 100 % cell lysis at concentration 10 A mu g/ml.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 14348-75-5 is helpful to your research. Computed Properties of https://www.ambeed.com/products/14348-75-5.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 31618-90-3, Name is (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OCP(OCC)(OCC)=O)=O, belongs to phthalazine compound. In a document, author is Thiel, Oliver R., introduce the new discover, Formula: https://www.ambeed.com/products/31618-90-3.html.

The need to access different heterocyclic cores as part of p38 MAP kinase inhibitors led to the discovery and development of several efficient approaches to three separate classes of heterocycles, namely phthalazines, pyrazolopyridinones, and triazolopyridines. This account summarizes our studies in this field in a comprehensive fashion. 1 Introduction 2 Synthesis of Phthalazine-Based p38 Inhibitors 2.1 Synthesis of Clinical Candidate 2 2.2 Synthesis of Clinical Candidate 3 3 Synthesis of Pyrazolopyridinone-Based p38 Inhibitors 4 Synthesis of Triazolopyridine-Based p38 Inhibitors 4.1 Synthesis through Pd-Catalyzed Benzhydrazide Couplings 4.2 Synthesis through Pd-Catalyzed Benzhydrazone Couplings 5.0 Conclusions

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 31618-90-3 is helpful to your research. Formula: https://www.ambeed.com/products/31618-90-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 35661-39-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 35661-39-3, Name is Fmoc-Ala-OH, SMILES is C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, belongs to phthalazine compound. In a article, author is Shahsavani, Mohammad Bagher, introduce new discover of the category.

In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (mu-NN) (mu-dppm) PtMe2] (1), and cis,cis-[Me2Pt(mu-NN)(mu dppm,) Pt((CH2)(4))] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells. Using different biophysical techniques and docking simulation analysis, we indicated that these complexes were also capable to interact efficiently with DNA via a non-intercalative mechanism. According to our results, substitution of cyclopentane (in complex 2) with two methyl groups (in complex 1) results in significant improvement of the complex ability to interact with DNA and subsequently to induce the anticancer activity. Overall, these binuclear Pt (II) complexes are promising group of the non-classical potential anticancer agents which can be considered as molecular templates in designing of highly efficient platinum anticancer drugs. (C) 2016 Elsevier B.V. All rights reserved.

Reference of 35661-39-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 35661-39-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 523-27-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, belongs to phthalazine compound. In a article, author is Zhu, Mingfei, introduce new discover of the category.

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However, the adverse effects and drug resistance restricted the use of Hh inhibitors. In the present study, 61 synthesized compounds containing central backbone of phthalazine or dimethylpyridazine were screened as candidates of new Hh signaling inhibitors by performing dual luciferase reporter assay. Among the compounds, L-4 exhibited an IC50 value of 2.33 nM in the Shh-Light II assay. L-4 strongly inhibited the Hh pathway in vitro and blocked the Hh pathway by antagonizing the smoothened receptor (Smo). Remarkably, L-4 could significantly suppress the Hh pathway activity provoked by Smo mutant (D473H) which showed strong resistant properties to existing drugs such as Vismodegib. Orally administered L-4 exhibited prominent dose-dependent anti-tumor efficacy in vivo in Ptch+/-; p53-/- MB allograft model. Furthermore, L-4 showed good tolerance in acute toxicity test using ICR mice. These evidences indicated that L-4 was a potent, well-tolerated, orally active inhibitor of Hedgehog pathway, and might be a promising candidate in development of Hh-targeted anti-cancer drugs.

Synthetic Route of 523-27-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 523-27-3 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 1439-36-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a article, author is Mohamadpour, Farzaneh, introduce new discover of the category.

We have studied the catalytic ability of copper(II) acetate monohydrate as a mild, environmentally benign, natural and economical catalyst for the multi-component efficient synthesis of biologically active spiro-4H-pyran derivatives and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with excellent yields and short reaction times. The most important advantages of this procedure are its mild, non-toxic and inexpensive catalyst, one-pot synthesis, environmentally benign nature, solvent-free conditions, simple operational procedures, and highly efficient conditions. [GRAPHICS] .

Reference of 1439-36-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1439-36-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem