Tag: M.W:300-400

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 36809-26-4, Name is (4-Bromophenyl)diphenylamine, molecular formula is C18H14BrN, belongs to phthalazines compound, is a common compound. In a patnet, author is Behalo, Mohamed S., once mentioned the new application about 36809-26-4, Computed Properties of C18H14BrN.

Synthesis of Novel Phthalazine Derivatives as Potential Anticancer and Antioxidant Agents Based on 1-Chloro-4-(4-phenoxyphenyl)phthalazine

A new series of phthalazine derivatives was synthesized from the reaction of 1-chloro-4-(4-phenoxyphenyl)phthalazine as a reactive starting material with different carbon, nitrogen, oxygen, and sulfur nucleophiles. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data (IR, H-1 NMR, C-13 NMR, and mass spectra). Some of the synthesized derivatives were screened for their antitumor activity against four human tumor cell lines using MTT assay. In comparison with doxorubicin as standard drug, compounds 1, 20, and 25 showed the most potent cytotoxic effect. In addition, investigation of antioxidant activity revealed that hydrazinylphthalazine 20 has the highest activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 14348-75-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 14348-75-5, Name is 2,7-Dibromo-9H-fluoren-9-one, SMILES is C3=C2C1=C(C=C(Br)C=C1)C(C2=CC(=C3)Br)=O, belongs to phthalazines compound. In a article, author is Turhan, K., introduce new discover of the category.

Efficient One-Pot Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-trione Derivatives Catalyzed by Y(OTf)(3)

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.

Electric Literature of 14348-75-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 14348-75-5 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Ziarani, Ghodsi Mohammadi, once mentioned the application of 198561-07-8, Name is Fmoc-Pra-OH, molecular formula is C20H17NO4, molecular weight is 335.35, MDL number is MFCD01075095, category is phthalazines. Now introduce a scientific discovery about this category, COA of Formula: C20H17NO4.

SULFONIC ACID FUNCTIONALIZED NANOPOROUS SILICA (SBA-PR-SO3H) AS AN EFFICIENT CATALYST FOR THE ONE-POT SYNTHESIS OF 2H-INDAZOLO[1,2-B] PHTHALAZINE-TRIONES

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with a pore size of 6 nm is an efficient catalyst in the green three-component condensation of phthalhydrazide, dimedone and aldehydes to give 2H-indazolo[1,2-b] phthalazine-triones under solvent-free conditions in excellent yields and short reaction times.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Saadati-Moshtaghin, Hamid Reza, once mentioned the application of 13001-40-6, Name is 4,4′-(1,4-Phenylenebis(ethene-2,1-diyl))dibenzonitrile, molecular formula is C24H16N2, molecular weight is 332.3973, MDL number is MFCD00369832, category is phthalazines. Now introduce a scientific discovery about this category, HPLC of Formula: C24H16N2.

Synthesis and characterization of magnetically recoverable 1-(copperferritesiloxypropyl)-3-methylimidazolium heteropolytungstate ionic liquid as a new nanocatalyst for the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

A novel, efficient and magnetically recoverable nanomaterial consisting of heteropoly acid supported on ionic liquid-modified copper ferrite nanoparticle was prepared and performed as a heterogeneous catalyst in the fast and convenient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives under mild and solvent-free conditions. The synthesized nanomaterial was characterized with FT-IR, XRD, FESEM, TEM, ICP and VSM. Furthermore, the obtained nanomaterial displayed striking reusability in the titled catalytic reaction. Compared with the various previously reported catalysts, the newly synthesized nanocatalyst is found to be most efficient with regard to operation simplicity, reaction time, yield and ease of catalyst separation.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yu, Hai-Ling, once mentioned the application of 36809-26-4, Name is (4-Bromophenyl)diphenylamine, molecular formula is C18H14BrN, molecular weight is 324.21, MDL number is MFCD01851266, category is phthalazines. Now introduce a scientific discovery about this category, Quality Control of (4-Bromophenyl)diphenylamine.

Anti-inflammatory and antinociceptive effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine in mice

Background: QUAN-0808 (6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine), a new phthalazine tetrazole derivative, was evaluated for the anti-inflammatory and analgesic effects. Methods: Xylene-induced ear edema, carrageenan (Carr)-induced paw edema, and acetic acid-induced capillary permeability hyperactivity in mice were used to assess the anti-inflammatory effect; acetic acid-induced writhing and hot plate responses for the analgesic activity. Results: In the present study, QUAN-0808 (100, 200, 400 mg/kg) and indomethacin (Indo) significantly decreased xylene-induced ear edema by 33.3, 37.5, 46.6, and 45.1%, respectively, decreased Carr-induced paw edema at 1, 2, 4 h after Carr injection, and decreased the prostaglandin E-2 (PGE(2)) and nitric oxide (NO) levels on the edema paw at 4 h after Carr injection; QUAN-0808 (100, 200,400 mg/kg), and aspirin (Asp, 200 mg/kg) significantly decreased Evans blue exudation in acetic acid-induced capillary permeability hyperactivity model by 26.7, 28.7, 32.3 and 29.1%, respectively, and decreased the numbers of acetic acid-induced writhing response in 15 min by 40.4, 53.6, 66.4, and 64.5%, respectively. Morphine (10 mg/kg) significantly increased the latency of the hot plate response by 136.5, 117.4, 67.5, and 22.7%, respectively, at 30, 60, 90, 120 min after intraperitoneal injection of morphine; however, QUAN-0808 (100, 200 and 400 mg/kg) did not produce significantly antinociceptive effects in the hot plate test, suggesting that its antinociceptive action occurs via peripheral rather than a central-acting mechanism. Conclusions: These results show that QUAN-0808 produced potential anti-inflammatory and peripheral antinociceptive effects, and indicated that the antinociceptive effects of QUAN-0808 were related to its anti-inflammatory activity in a dose-dependent manner. Therefore, as inflammation is a peripheral process, it is suggested that QUAN-0808 exerted peripheral effects. The peripheral effect mechanisms of QUAN-0808 may be related to a decrease in the production of PGR(2), NO, bradykinin and other inflammatory mediators.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3. In an article, author is Zhang Luye,once mentioned of 81-48-1, SDS of cas: 81-48-1.

Synthesis and Antitumor Activity of Novel 1,3-Disubstituted Pyridazinone Derivatives

In order to find more efficient and low toxicity antitumor drugs, a series of novel 1,3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H)-yl)-N-(2-fluorophenyl)acetamide (5g) exhibited better antiproliferative activities with IC50 value of 6.01 mu mol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 1439-36-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazines compound. In a article, author is Simijonovic, Dusica, introduce new discover of the category.

Synthesis, structural characterization, and molecular docking study of new phthalhydrazide-coumarin hybrids

A series of new phthalhydrazide-coumarin hybrids was obtained in the reaction of phthalhydrazide with corresponding bromopropoxycoumarin derivatives. These reactions were performed in the presence of Cs2CO3, in acetonitrile as solvent, and under reflux for 5 h. Obtained hybrids contain one or two coumarin scaffolds bonded to phthalhydrazide nitrogen via propoxy linker. Ten new phthalhydrazide-coumarin hybrids were obtained in moderate to good yields, and characterized with melting point, elemental analysis, IR and NMR spectroscopy, and LC-MS spectrometry. Additionally, the structures of these compounds were elucidated based on experimental and theoretical data (IR, H-1 NMR, and C-13 NMR). Excellent agreement between experimental and simulated spectra was achieved. The prediction of the potential biological activity of synthesized compounds was done using the online program PASS (Prediction of Activity Spectra for Substances). Based on the obtained results, the serotonin 2A receptor (5-HT2AR) was selected for molecular docking study. Molecular docking was also performed with commercially available drug Risperidone, and obtained results were compared with potential bioactive conformations of obtained phthalhydrazide-coumarin hybrids. (C) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 1439-36-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1439-36-7.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Computed Properties of C13H6Br2O, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14348-75-5, Name is 2,7-Dibromo-9H-fluoren-9-one, molecular formula is C13H6Br2O, belongs to phthalazines compound. In a document, author is Rizk, Sameh A..

Design, Regiospecific Green Synthesis, Chemical Computational Analysis, and Antimicrobial Evaluation of Novel Phthalazine Heterocycles

Phthalazines have received considerable attention for their wide antimicrobial activity. Regiospecific nucleophilic attack of 4-benzylphthalazin-1-ol by the 1-oxo rather than the aza group on different alkyl halides gave novel phthalazine heterocyclic derivatives. Moreover, a variety of nucleosides bonded to electron-withdrawing groups were synthesized using 4-benzylphthalazine-1-ol. The density functional theory has been used to investigate the electronic structure of the synthesized compounds. All of the synthesized derivatives showed remarkable activity when tested against Gram-positive and Gram-negative bacteria, Aspergillus niger, and Candida albicans. The reactivity of these nucleosides was expected to arise from their bonding with the lone pair of N-atom of the macromolecules of bacteria. These bonding were expected to inhibit the enzyme by forming highly stable complex with lower highest occupied molecular orbital energy. The structures of these synthesized derivatives were established by Fourier transform infrared, H-1-NMR, and C-13-NMR spectroscopic evidence.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14348-75-5. Computed Properties of C13H6Br2O.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3, belongs to phthalazines compound, is a common compound. In a patnet, author is Sangani, Chetan B., once mentioned the new application about 81-48-1, Recommanded Product: 81-48-1.

Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: assessment of their antimicrobial, antituberculosis and antioxidant activity

A new series of pyrazolo[1,2-b]phthalazine derivatives (4a-p) bearing the 5-aryloxypyrazole nucleus was synthesized by one-pot, three-component, base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), malononitrile or ethyl cyanoacetate (2a-b) and 2,3-dihydro-1,4-phthalazinedione (3a-b) in ethanol containing an eco friendly base, NaOH, in good to excellent yields. All synthesized compounds (4a-p) were duly characterized by physico-chemical parameters, H-1 NMR, C-13 NMR, FT-IR and LCMS techniques. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 4e, 4g, 4h, 4k and 4o exhibited excellent antimicrobial activity compared with first line drugs. In vitro antituberculosis activity was evaluated against Mycobacterium tuberculosis H37Rv, and compounds 4g and 4o emerged as the promising antimicrobial members with better antituberculosis activity. A brine shrimp bioassay was carried out to study the in vitro cytotoxic properties of the synthesized compounds. In vitro antioxidant activity was evaluated by the ferric-reducing antioxidant power method. Compounds 4c, 4d, 4g and 4h showed the highest antioxidant potencies.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 81-48-1. The above is the message from the blog manager. Recommanded Product: 81-48-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C20H17NO4, 198561-07-8, Name is Fmoc-Pra-OH, SMILES is C#CC[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, belongs to phthalazines compound. In a document, author is Romero, Angel H., introduce the new discover.

Antileismanial activity, mechanism of action study and molecular docking of 1,4-bis(substituted benzalhydrazino)phthalazines

To identify new agents for the treatment of American cutaneous leishmaniasis, a series of eight 1,4-bis(substituted benzalhydrazino)phthalazines was evaluated against Leishmania braziliensis and Leishmania mexicana parasites. These compounds represent a disubstituted version of the 1-chloro-4-(monoaryl/heteroarylhydranizyl)phthalazine that exhibited a significant response against L. braziliensis according to our previous findings. Two disubstituted phthalazines 3b and 3f were identified as potential antileishmanial agents against L. braziliensis parasites, exhibiting a submicromolar IC50 response of 2.37 and 7.90 mu M on the promastigote form, and of 1.82 and 4.56 mu M against intracellular amastigotes, respectively. In particular, compound 3b showed interesting responses against amastigote isolates from reference, glucantime-resistant and clinical human strains, which were by far superior to the biological response found for the glucantime drug. With regard to the toxicity results, both 3b and 3f exhibited moderate LD50 values against murine macrophages (BMDM), with good selectivity indexes on promastigotes and intracellular amastigotes of L. braziliensis. A comparison of biological response was established between the monosubstituted and disubstituted versions of these benzalhydrazino-phthalazines. Easy synthetic procedure and significant response against amastigote strains including against resistant lines made compound 3b a potential candidate for further pharmacokinetic and in vivo experiments as antileishmanial agent, and as a platform for further structural optimization. Mechanism-of-action studies and molecular docking simulations discarded to inhibition of superoxide dismutase as possible mode of action.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 198561-07-8. Formula: C20H17NO4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem