Tag: M.W=400-500

Electric Literature of 3648-20-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 3648-20-2, Name is Diundecyl phthalate, SMILES is O=C(OCCCCCCCCCCC)C1=CC=CC=C1C(OCCCCCCCCCCC)=O, belongs to phthalazines compound. In a article, author is Boraei, Ahmed T. A., introduce new discover of the category.

Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma

Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a privilege moiety that is incorporated in a big number of anticancer drugs in clinical use or that are still under clinical or preclinical studies. We utilized the drug extension strategy to tailor the designed compounds to fit the EGFR hydrophobic sub pocket and cleft region. The designed phthalazine derivatives was synthesized by linking phthalazine moiety with 1,3,4-oxadiazole-thione and 1,2,4-triazole-thione. Alkylation and glycosylation of the new heterocyclic systems were successfully performed to be used in the drug extension. Coupling of some phthalazine derivatives with different amino acids was also performed to improve the drug selectivity. The synthesized compounds were tested for their antiproliferative activity against cancer cells both in vivo and in vitro. The in vitro activity against hepatocellular carcinoma (HepG2 cell line) ranged from 5.7 mu g/mL to 43.4 mu g/mL. Compounds 31a and 16 were the most active with an IC(50)5.7 mu g/mL and 7.09 mu g/mL, respectively compared to the standard compound doxorubicin (4.0 mu g/mL). In vivo, compounds 10 and 16 showed IC50 values 7.25 mu g/mL and 7.5 mu g/mL, respectively compared to the standard compound cisplatin (IC50, 9.0 mu g/mL). In silico, testing of the phthalazine derivatives showed that they are good inhibitors for EGFR. The docking studies substantiated compounds 4, 10, 16 and 31a as new lead compounds and identified Arg841 as a key residue in the cleft region for binding stronger inhibitors.

Electric Literature of 3648-20-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 3648-20-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: phthalazines, 3648-20-2, Name is Diundecyl phthalate, molecular formula is C30H50O4, belongs to phthalazines compound. In a document, author is Dong, Yong Ping, introduce the new discover.

Enhancing and inhibiting effects of benzenediols on chemiluminescence of a novel cyclometallated iridium(III) complex

A novel chemiluminescence (CL) system, including the cyclometallated iridium(III) complex {tris[1-(2,6-dimethylphenoxy)-4-(4-chlorophenyl)phthalazine]iridium}, potassium permanganate and oxalic acid, is proposed for the determination of benzenediols. This method is based on the fact that hydroquinone and catechol exhibited an inhibiting effect, while resorcinol exhibited an enhancing effect on CL intensity. The optimum conditions for CL emission were investigated. Under optimal conditions, the detection limits of hydroquinone, catechol and resorcinol were 6.4?x?10-8, 2.7?x?10-9 and 8.1?x?10-7?mol/L, respectively. The method has been successfully applied to the determination of benzenediols in different types of water sample. The luminophors of the CL systems were all identified as the metalligand charge-transfer (MLCT) excited state of the iridium complex. Copyright (c) 2011 John Wiley & Sons, Ltd.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3648-20-2. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 62965-37-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 62965-37-1, Name is Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, SMILES is C1CCC(CC1)NC1CCCCC1.[H][C@@](NC(=O)OCC1=CC=CC=C1)(C(O)=O)C(C)(C)C, belongs to phthalazines compound. In a article, author is Patil, Smita, introduce new discover of the category.

A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co2+ in semi-aqueous medium: application in cancer cell imaging

A new phthalazine based chemosensor 3 was developed for the highly selective and sensitive detection of Co2+ in the mixed solvent system, CH3CN- H2O ( 1 : 1, v/ v). In the presence of Co2+, the colour of the solution 3 changed from yellow to green; the absorption maxima of 3 was red- shifted from 383 nm to 435 nm, and the fluorescence of 3 at 550 nm was significantly enhanced. The sensor 3 showed a detection limit down to 25 nM by forming a complex species with Co2+ in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co2+ in living cells.

Electric Literature of 62965-37-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 62965-37-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 3648-20-2, Name is Diundecyl phthalate, molecular formula is , belongs to phthalazines compound. In a document, author is Ye, Shang-hui, SDS of cas: 3648-20-2.

Solution processed single-emissive-layer white organic light-emitting diodes based on fluorene host: Balanced consideration for color quality and electroluminescent efficiency

Cost-effective fabrication of white organic light-emitting diodes (WOLED) is meaningful toward commercial application of environment-friendly solid-state lighting sources. Electroluminescent efficiency and color quality are two opposite performance characteristics facing solution processed WOLEDs requiring balanced consideration. Herein, a recently synthesized molecule of 4,4′-(9,9′-(1,3-phenylene) bis(9H-fluorene-9,9-diyl)) bis(N,N-diphenylaniline) (DTPAFB) is introduced as a host material for solution processed all-phosphor WOLEDs, embracing four well-known molecules which are blue iridium (III) bis(2-(4,6-difluorophenyl) pyridinato-N,C-2)(picolinate) (FIrpic), green iridium (III) bis[2-(2-pyridinyl-N) phenyl-C](2,4-pentanedionato-O-2,O-4)[Ir(ppy)(2)(acac)], and orange iridium (III) bis(2-phenyl-benzothiazole-C-2, N)(acetylacetonate) [Ir(bt)(2)(acac)] plus a home-made red phosphor of iridium (III) tris(1-(2,6dimethylphenoxy)-4-(4-chlorophenyl) phthalazine) [Ir(MPCPPZ)(3)]. Illumination quality white light with high brightness, high efficiency, suitable correlated color temperature (CCT), high color-rendering index (CRI), and stable electroluminescent (EL) emission is obtained. A stable white emission with a CRI over 70, Commission Internationale de L’Eclairage (CIE) of (0.37, 0.42), and high EL efficiency of 19.6 lm W-1 at high luminance of 2000 cd m(-2) for blue/orange complementary color WOLEDs is demonstrated. The optimized red/green/blue three primary color WOLEDs show improved CRI up to 81, moderate high efficiency of 25.8 cd A(-1), 14.4 lm W-1, and EQE of 13.9%. Furthermore, the red/green/blue/orange four primary color WOLEDs show the optional balance between color quality and EL efficiency with high CRI of around 81-83 and medium CCT of 3755-3929 K which is warm and soft to human eyes. At an illumination relevant luminance of 1000 cd m(-2), the total power efficiency reaches 33.6 lmW(-1), and still remains 30.2 lm W-1 at 3000 cd m(-2), approaching the efficiency of state-of-the-art fluorescent-tube (40 – 70 lm W-1), potentially suitable as an environment-friendly solid-state lighting source. This work indicates that developing high performance host materials and highly efficient phosphors and carefully combining them with common phosphors is an effective way toward high performance WOLEDs. (C) 2016 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3648-20-2, in my other articles. SDS of cas: 3648-20-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3648-20-2, Name is Diundecyl phthalate, formurla is C30H50O4. In a document, author is Linko, R. V., introducing its new discovery. Product Details of 3648-20-2.

Synthesis, crystal structure, and spectroscopic studies of 10-(1-phthalazinylazo)-9-phenanthrol (HL). Complexation of cadmium and zinc chlorides with HL

10-(1-Phthalazinylazo)-9-phenanthrol (HL, I) was synthesized by the reaction between 1-hydrazinophthalazine and 9,10-phenanthrenequinone. The crystal and molecular structures of compound I were determined by X-ray diffraction (XRD). According to XRD, EAS, and H-1 and C-13 NMR data, a HL molecule in solutions and in crystals exists in the form of quinohydrazone tautomer (b) (s-trans, cis) stabilized by intramolecular N(3)H…O(1) hydrogen bond. The mobile H atom is localized at the N(3) atom of the azo group. The phthalazine (A) and phenanthrenequinone (B) moieties of the HL molecule are nearly coplanar. The HL basicity and acidity constants (pK(a) = 1.90 and pK(a) = 11.65, respectively) and the formation constants of HL complexes with Zn2+ and Cd2+ and their compositions in solutions were determined. ML2 center dot DMFA complexes, where M = Zn2+, Cd2+, were synthesized. The coordination mode of the L- ligand with metal atoms was suggested.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3648-20-2 help many people in the next few years. Product Details of 3648-20-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 62965-37-1, Name is Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, molecular formula is C26H42N2O4, belongs to phthalazines compound. In a document, author is El-Hashash, Maher A., introduce the new discover, Formula: C26H42N2O4.

Synthesis and Antimicrobial Activity of Some Condensed [4-(2,4,6-Trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic Acid Hydrazide

Some new 1,2,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-2,4,6-trimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, 1H NMR, 13C NMR, MS and elemental analysis. The new compounds were synthesized with the objective of studying their antimicrobial activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 62965-37-1. Formula: C26H42N2O4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

3648-20-2, Name is Diundecyl phthalate, molecular formula is C30H50O4, Safety of Diundecyl phthalate, belongs to phthalazines compound, is a common compound. In a patnet, author is Maheshwari, D. P. Loka, once mentioned the new application about 3648-20-2.

ONE-POT SYNTHESES OF 1H-PYRAZOLO[1,2-B]PHTHALAZINE-5,10-DIONES IN MOLTEN TBAB

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) have been achieved from phthaloyl dichloride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) or ethyl cynoacetate (4b) in molten Tetrabutylammonium Bromide as medium at 100-105 degrees C for 20-30 min by in-situ generation of HCl as a catalyst. These reactions have an easy workup, provide excellent yields, and use TBAB as the reaction medium.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3648-20-2 help many people in the next few years. Safety of Diundecyl phthalate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 3648-20-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 3648-20-2, Name is Diundecyl phthalate, SMILES is O=C(OCCCCCCCCCCC)C1=CC=CC=C1C(OCCCCCCCCCCC)=O, belongs to phthalazines compound. In a article, author is Tuerkmen, Yunus E., introduce new discover of the category.

Silver-Catalyzed Formal Inverse Electron-Demand Diels-Alder Reaction of 1,2-Diazines and Siloxy Alkynes

A highly effective silver-catalyzed formal inverse electron-demand Diets Alder reaction of 1,2-diazines and siloxy alkynes has been developed. The reactions provide ready access to a wide range of siloxy naphthalenes and anthracenes, which are formed in good to high yields, under mild reaction conditions, using low catalyst loadings.

Application of 3648-20-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 3648-20-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Davarpanah, Jamal, once mentioned the application of 3648-20-2, Name is Diundecyl phthalate, molecular formula is C30H50O4, molecular weight is 474.7156, MDL number is MFCD00043729, category is phthalazines. Now introduce a scientific discovery about this category, Safety of Diundecyl phthalate.

Nano Bronsted solid acid containing double-charged diazoniabi-cyclo[2.2.2]octane chloride supported on nano rice husk silica: an efficient catalyst for the one-pot synthesis of phthalazine compounds

In the present work, amorphous silica nanoparticles were synthesized from low-cost rice husk ash (RH-SiO2). The nanoparticles were later modified by an acidic ionic liquid containing double-charged diazoniabi-cyclo[2.2.2]octane chloride using sol-gel method (RH@[SiPrDABCO@BuSO3H]HSO4). The structural properties of this Bronsted solid acid were systematically investigated by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermal gravimetric analysis-derivative thermogravimetric analysis (TGA-DTG), and Brunauer-Emmett-Teller (BET) measurements. The catalytic activity of this nanocomposite was successfully tested through the one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones via three-component couplings of phthalhydrazide, aromatic aldehydes, and malononitrile. The heterogeneous catalyst could be recovered easily and reused without significant loss of its catalytic activity.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 3648-20-2, Safety of Diundecyl phthalate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 62965-37-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 62965-37-1, Name is Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, SMILES is C1CCC(CC1)NC1CCCCC1.[H][C@@](NC(=O)OCC1=CC=CC=C1)(C(O)=O)C(C)(C)C, belongs to phthalazines compound. In a article, author is Ebrahimiasl, Hakimeh, introduce new discover of the category.

Synthesis of Fe3O4-supported Schiff base Cu (II) complex: a novel efficient and recyclable magnetic nanocatalyst for one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives

In this research, synthesis and characterization of a novel Schiff base Cu (II) complex immobilized on Fe3O4@SiO(2)nanoparticles are reported. Then, the catalytic activity of these nanoparticles as magnetic recyclable nanocatalyst was explored for the one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives. The reactions proceeded smoothly to provide the respective products in excellent yields under green conditions. Facile preparation of the catalyst, high yields of the products, low reaction times, and use of water as green solvent are the main advantages of the present protocol. Moreover, the catalyst can be easily separated from the reaction mixture in a magnetic field, recycled and reused for six consecutive fresh runs without considerable loss of catalytic activity. Graphic abstract

Synthetic Route of 62965-37-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 62965-37-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem