Tag: M.W=600-700

Related Products of 56-95-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a article, author is Romero, Angel H., introduce new discover of the category.

With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in the world. A structure-activity relationship permitted to identify two phthalazines containing nitroheterocyclic moiety 31 and 3m as promising new lead compounds. These compounds showed a significant antileishmanial activity against promastigote form of L. braziliensis, with EC50 values in sub-micromolar and nanomolar ranges. The phthalazine 31 also displayed a selective and excellent activity against the clinically relevant intracellular amastigotes form, with a EC50 value in sub-micromolar range (0.59 mu M), without affecting the viability of the host cells. Oxidative stress was identified as the possible mode of action of the most active phthalazine. Considering their significant antileishmanial activity and ease synthesis, the phthalazine containing nitroheterocyclic represents a promising agent against Leishmania braziliensis for the rational design of new leads. (C) 2017 Elsevier Masson SAS. All rights reserved.

Related Products of 56-95-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 56-95-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 737-31-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, SMILES is O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.[Na+], belongs to phthalazine compound. In a article, author is Han, Young Taek, introduce new discover of the category.

In the recent decades, N-heterocycles are widely used as versatile scaffolds for the development of biologically active compounds and considered as one of the privileged structures. Among the various N-heterocycles, benzodiazines, a series of bicyclic heterocycles in which benzene rings are fused with 6-membered heterocycles containing two nitrogens are especially interesting, due to their structural conciseness and usefulness as synthetic intermediates, and suitable physicochemical properties as potential drug candidates and chemical probes. For this reason, a series of synthetic methodologies for benzodiazines has been developed and generally used in organic and medicinal chemistry fields. Interestingly, synthesis of quinazoline, a kind of benzodiazine in which benzene is fused with pyrimidine, has been extensively reviewed, while cinnoline, phthalazine and quinoxaline, benzene fused with pyridazine or pyrazine, have been relatively less investigated. In this review, recent advances in the synthesis of biologically active benzodiazines, benzene ring-fused 6-membered heterocycles with two nitrogen atoms, cinnoline, phthalazine and quinoxaline, will be addressed. In each section, biological activities of various benzodiazines, recently served as novel scaffolds for drug discovery, are briefly summarized for comprehensive understanding of biological and medicinal significance in advance. Moreover, intensive investigation of the synthetic approaches to various benzodiazines such as cinnoline, phthalazine and quinoxaline is followed. It would hopefully be helpful for the readers who have interests in developing novel drug candidates and related useful chemical probes.

Reference of 737-31-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 737-31-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a document, author is Ferreira, Pedro, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/56-95-1.html.

The mechanism of oxidation of N-heterocycle phthalazine to phthalazin-1(2H)-one and its associated free energy profile, catalyzed by human aldehyde oxidase (hAOX1), was studied in atomistic detail using QM/MM methodologies. The studied reaction was found to involve three sequential steps: (i) protonation of the substrate’s N2 atom by Lys893, (ii) nucleophilic attack of the hydroxyl group of the molybdenum cofactor (Moco) to the substrate, and (iii) hydride transfer from the substrate to the sulfur atom of the Moco. The free energy profile that was calculated revealed that the rate-limiting step corresponds to hydride transfer. It was also found that Lys893 plays a relevant role in the reaction, being important not only for the anchorage of the substrate close to the Moco, but also in the catalytic reaction. The variations of the oxidation state of the molybdenum ion throughout the catalytic cycle were examined too. We found out that during the displacement of the products away from the Moco, the transfer of electrons from the catalytic site to the FAD site was proton-coupled. As a consequence, the most favorable and fastest pathway for the enzyme to complete its catalytic cycle was that with Mo-v and a deprotonated SH ligand of the Moco with the FAD molecule converted to its semiquinone form, FADH(center dot).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 56-95-1 is helpful to your research. HPLC of Formula: https://www.ambeed.com/products/56-95-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 737-31-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, SMILES is O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.[Na+], belongs to phthalazine compound. In a article, author is Jiang, Lilin, introduce new discover of the category.

Cu@Fe3O4 MNPs as novel nanomagnetic reagents were prepared to investigate their catalytic behavior in the preparation of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones, as important biologically active compounds. Then, characterization of the synthesized nanoparticles was performed using different methods including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), energy dispersive X-ray (EDX), and scanning electron microscopy (SEM). All reactions were performed with small amounts of the Cu@Fe3O4 MNPs under solvent-free conditions. After completion of the reaction, because of the magnetic nature of the nanocatalyst, they could be simply separated with an external magnet and easily reused with no considerable decrease in the catalytic behavior even after seven runs.

Application of 737-31-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 737-31-5 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 737-31-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, SMILES is O=C([O-])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.[Na+], belongs to phthalazine compound. In a article, author is Hosseininasab, N., introduce new discover of the category.

A novel heterogeneous acidic ionic liquid based on functionalized imidazolium salt of phosphotungstic acid (H3PW12O40, denoted as PW), immobilized on CuFe2O4@SiO2 magnetic nanoparticles, denoted as CuFe2O4@SiO2@C-3-Imid-C4SO3-PW, was prepared and characterized using FT-IR, SEM, EDX, and VSM techniques. High activity of the prepared material as a novel catalyst was evaluated in one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by reaction of phthalhydrazide with an aromatic aldehyde and malononitrile under solvent-free conditions. The process gave high yields of the products over short reaction time. The catalyst was efficiently recovered by magnetic decantation and used repeatedly without significant loss of its activity.

Reference of 737-31-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 737-31-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 56-95-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a article, author is Maleki, Behrooz, introduce new discover of the category.

Lewis acid free synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-triones promoted by 1,1,1,3,3,3-hexafluoro-2-propanol

A convenient, environmentally friendly and efficient procedure for the synthesis 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-trione derivatives has been developed via multi-component and one-pot reactions of various aldehydes with cyclic 1,3-diketones and phthalhydrazide 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). In simple and mild reaction conditions, the use of HFIP is explored as an easy workup and a green catalyst for the one-pot three-component synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H, 13H)-triones. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.

Reference of 56-95-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 56-95-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 737-31-5, Name is Sodium 3,5-diacetamido-2,4,6-triiodobenzoate, molecular formula is C11H8I3N2NaO4, belongs to phthalazine compound, is a common compound. In a patnet, author is Raghavendra, G. Jeevan, once mentioned the new application about 737-31-5, Application In Synthesis of Sodium 3,5-diacetamido-2,4,6-triiodobenzoate.

One-Pot Four Component Synthesis of 3-Amino-1-(1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine Derivatives Mediated by [DBUH][OAc]

One-pot, four component, green, and efficient synthesis of 3-amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine derivatives by reaction of phthalic anhydride with hydrazine hydrate, 5-nitro-1H-indole-3-carboxaldehyde-indole-3-carboxaldehydes and malononitrile-ethyl cyanoacetate in the presence of [DBUH][OAc] at 60-65 degrees C is developed. The method is characterized by short reaction time, high yields, and purity of products formed.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 737-31-5. The above is the message from the blog manager. Application In Synthesis of Sodium 3,5-diacetamido-2,4,6-triiodobenzoate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 56-95-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a article, author is Wang Wang, introduce new discover of the category.

An improved procedure for the three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using basic ionic liquid

An efficient and green method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been achieved through the one-pot, three-component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and phthalhydrazide in the presence of 1-butyl-3-methyl imidazolium hydroxide ([bmim]OH) as catalyst in EtOH. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid can be recovered and recycled for subsequent reactions. Moreover, this protocol has the advantages of easy work-up, short reaction time, mild reaction conditions and environmentally benign procedures compared with the reported methods.

Application of 56-95-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 56-95-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 56-95-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a article, author is Taslimi, Parham, introduce new discover of the category.

Cholinesterases, alpha-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer’s disease and diabetes mellitus

In this study, using the Cu(OTf)(2) catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzymes with K-i values in the range of 4.88-15.94 nM for hCA I, 7.04-20.83 nM for hCA II, 68.25-158.27 for AChE, 60.17-91.27 for BChE and 0.36-2.36 nM for alpha-Gly, respectively. In silico studies were performed on the molecules inhibiting hCA I, hCA II, AChE, BChE and alpha-Gly receptors. When we evaluated the data obtained in this work, we determined the inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors. Reference inhibitors were used for all enzymes.

Related Products of 56-95-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 56-95-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem