As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazin-1(2H)-one, and cas is 119-39-1, its synthesis route is as follows.,119-39-1
General procedure: The precursor lactam (1 mmol) was dissolved in DMF-TEA 1:1(2 mL), then K2CO3 (0.410 g, 3 mmol), CuI (190 mg, 1 mmol),PdCl2(PPh3)2 (17.5 mg, 0.025 mmol) and aryl halide (1.1 mmol)were added to the solution. The reaction mixture was stirred underargon, at 110C for overnight. The reaction mixture was ltered andbrine (30 mL) was added to the solution. The precipitated solid wasltered off then washed with brine and water. The crude productwas puried by column chromatography (on silica, using DCM orDCM-MeOH 100-5:1 mixtures as eluent) and subsequent crystal-lization from MeOH, EtOH,iPrOH,tBuOH, MeOH-water or EtOH-water.
With the complex challenges of chemical substances, we look forward to future research findings about 119-39-1,belong phthalazine compound
Reference£º
Article; Jernei, Tamas; B?sze, Szilvia; Szabo, Rita; Hudecz, Ferenc; Majrik, Katalin; Csampai, Antal; Tetrahedron; vol. 73; 43; (2017); p. 6181 – 6192;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem