Tag: M.W=150-200

Li, L; Song, FF; Zhong, XM; Wu, YD; Zhang, XH; Chen, J; Huang, Y in [Li, Li; Song, Feifei; Wu, Yun-Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Genom, Shenzhen 518055, Guangdong, Peoples R China; [Zhong, Xiumei; Zhang, Xinhao; Chen, Jiean] Shenzhen Bay Lab, Shenzhen 518055, Guangdong, Peoples R China; [Huang, Yong] Hong Kong Univ Sci Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China published Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights in 2020.0, Cited 90.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Palladium-catalyzed cross-coupling reactions between carboxylic acids and aryl halides have several possible competitive pathways. Decarboxylative C-C bond coupling and C-H arylation are well established in the literature. However, direct C-O bond coupling between carboxylic acids and aryl halides has received little success. In this report, we describe a protocol for exclusive C-O bond formation, enabled by a bidentate N,N-ligand such as 1,10-phenanthroline. The reaction is general for a broad range of carboxylic acids and iodoarenes. Experimental evidence and computational results suggest a high energy barrier for the alternative pathway of decarboxylative carbon-carbon bond coupling.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 J MATER CHEM A published article about METAL-ORGANIC FRAMEWORK; NITRO-COMPOUNDS; P-NITROPHENOL; COPPER NANOPARTICLES; MODEL REACTION; REDUCTION; CARBON; SIZE; NANOCOMPOSITE; GREEN in [Sorenson, Anh H. T. Nguyen; Orcutt, Emma K.; Anderson, Hans C.; Stowers, Kara J.] Brigham Young Univ, Dept Chem, Provo, UT 84604 USA; [Sorenson, Anh H. T. Nguyen; Orcutt, Emma K.; Anderson, Hans C.; Stowers, Kara J.] Brigham Young Univ, Biochem Dept, Provo, UT 84604 USA; [Kent, Rosalyn, V; Matzger, Adam J.] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA; [Kent, Rosalyn, V; Matzger, Adam J.] Univ Michigan, Macromol Sci & Engn Program, 930 North Univ Ave, Ann Arbor, MI 48109 USA; [Wu, Yu] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Zigong 643000, Peoples R China in 2020.0, Cited 73.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

Metal-organic frameworks (MOFs) have recently emerged as efficient self-sacrificial templates to fabricate porous carbon-supported metal nanoparticles (NPs). Due to observed increased activity, catalysts containing bimetallic NPs represent an active frontier for heterogeneous catalyst development. A strategy to synthesize active catalysts with highly dispersed bimetallic metal/metal oxides within a porous carbon matrixviarapid MOF decomposition using dopants is presented in this paper. A 2,4,6-trinitrotoluene (TNT) additive enhances the rapid thermolysis of the metal-doped Cu-based MOFs to minimize particle aggregation. Catalyst characterization reveals that a secondary metal increases dispersion of both metals over the carbon composite support. The catalyst preparation method influences both the metal particle size and oxidation state. Catalytic performance shows increased rates for 4-nitrophenol reduction even with <1 wt% of added secondary metal. Among the synthesized catalysts, the Ni-CuO@C bimetallic catalyst exhibits outstanding activity. This synthetic strategy is useful for creating highly efficient, robust, non-noble metal catalysts for development of sustainable chemical processes. Recommanded Product: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about SELECTIVE DEPROTECTION; ESTERS; 2,5-DIMETHYLPHENACYL; TRANSPEPTIDASE; CHEMISTRY; ALCOHOLS; RELEASE; DIM, Saw an article supported by the Thousand Plan Youth Program; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; East China University of Science Technology. Product Details of 62-23-7. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Fang, ZJ; Li, YY; Xie, HX. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Reported herein is a novel 4-OTBS benzyl-based protective group for carboxylic acids. This protective group can be removed in the presence of TBAF or TFA with high efficiency, which makes it compatible with base-sensitive or acid-sensitive substrates. With this protective group, a near-infrared fluorogenic probe for the detection of gamma-glutamyltranspeptidase activities was readily prepared. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Engineering; Environmental Sciences & Ecology very interesting. Saw the article Novel Pathway for Chloramphenicol Catabolism in the Activated Sludge Bacterial Isolate Sphingobium sp. CAP-1 published in 2020.0. SDS of cas: 62-23-7, Reprint Addresses Liang, B; Wang, AJ (corresponding author), Harbin Inst Technol Shenzhen, Sch Civil & Environm Engn, Shenzhen 518055, Peoples R China.; Liang, B; Wang, AJ (corresponding author), Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China.; Liang, B; Wang, AJ (corresponding author), Harbin Inst Technol, Sch Environm, State Key Lab Urban Water Resource & Environm, Harbin 150090, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The chlorinated nitroaromatic antibiotic chloramphenicol (CAP) is a refractory contaminant that is widely present in various environments. However, few CAP-mineralizing bacteria have been documented, and a complete CAP catabolism pathway has yet to be identified. In this study, the bacterial strain Sphingobium sp. CAP-1 was isolated from an activated sludge sample and was shown to be capable of aerobically subsisting on CAP as the sole carbon, nitrogen, and energy source while simultaneously and efficiently degrading CAP. p-Nitrobenzoic acid (PNBA), p-nitrobenzaldehyde (PNBD), protocatechuate (PCA), and the novel side chain C-3 -hydroxy-oxygenated product of CAP (O-CAP) were identified during CAP degradation. Strain CAP-1 was able to convert O-CAP to intermediate product PNBA. The putative functional genes associated with PNBA catabolism into the tricarboxylic acid cycle via PCA and floc formation were also identified by genome sequencing and comparative proteome analysis. A complete pathway for CAP catabolism was proposed. The discovery of a novel CAP oxidation/detoxification process and a complete pathway for CAP catabolism enriches the fundamental understanding of the bacterial catabolism of antibiotics, providing new insights into the microbial-mediated fate, transformation, and resistance risk of CAP in the environment. The molecular basis of CAP catabolism and floc formation in strain CAP-1 also offers theoretical guidance for the enhanced bioremediation of CAP-containing environments.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about CHOLINESTERASE-INHIBITORS; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; CARBONIC-ANHYDRASE; DEMENTIA, Saw an article supported by the WissenschaftsCampus Halle WCH [W13004216]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Loesche, A; Wiemann, J; Rohmer, M; Brandt, W; Csuk, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The skeleton of the diterpene dehydroabietylamine was modified, and a set of 12-hydroxy-dehydroabietylamine derivatives was obtained. The compounds were screened in colorimetric Ellman’s assays to determine their ability to act as inhibitors for the enzymes acetylcholinesterase (AChE, from electric eel) and butyrylcholinesterase (BChE, from equine serum). Additional investigations concerning the enzyme kinetics were performed and showed 12-hydroxy-N-(4-nitro-benzoyl)dehydroabietylamine (13) and 12-hydroxy-N-(isonicotinoyl)dehydroabietylamine (17) as selective BChE inhibitors holding good inhibition constants K-i = 0.72 +/- 0.06 mu M and K-i = 0.86 +/- 0.19 mu M, respectively.

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Loesche, A; Wiemann, J; Rohmer, M; Brandt, W; Csuk, R or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about C-H BONDS; BENZOIC-ACID; MOLECULAR-OXYGEN; N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; METAL-FREE; PHOTOOXIDATION; DERIVATIVES; COBALT; OXIDE, Saw an article supported by the National Key Research and Development Program of China [2017YFC0210900]. Category: phthalazines. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A mild and metal-free procedure is reported for the aerobic oxidation of substituted toluenes to carboxylic acids by using CBr (4) as initiator under irradiation from a 400 nm blue light-emitting diode.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Thermodynamics; Chemistry; Engineering very interesting. Saw the article Estimation of vapor pressures of liquid and solid organic and organometallic compounds at 298.15 K published in 2020. Application In Synthesis of 4-Nitrobenzoic acid, Reprint Addresses Abraham, MH (corresponding author), UCL, Dept Chem, 20 Gordon St, London WC1H OAJ, England.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Equations for vapor pressure VP, as log VP, at 298.15 K for a set of 1016 liquid organic and organometallic compounds have been constructed using Abraham descriptors. The regression standard deviations of 0.28 and 0.31 log units are excellent by comparison with literature values for large data sets. Similar equations for a set of 359 solid organic and organometallic compounds were very poor, but if carboxylic acids were excluded we obtained equations for 261 compounds with standard deviations of 0.62 and 0.66 log units. For the 98 carboxylic acids taken separately we obtained equations with standard deviations of 0.84 and 0.91 log units. Equations for the carboxylic acids were substantially different to those that excluded carboxylic acids, due, we suggest, to the particular dimeric structure of the crystalline carboxylic acids. (C) 2020 Published by Elsevier B.V.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG LETT published article about PHOTOREDOX-CATALYSIS; FUNCTIONALIZATION; ALPHA; AMIDOALKYLATION; ETHERS in [Xu, Jin-hui; Wu, Wen-bin; Wu, Jie] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Ortho-alkylated and ortho-acylated pyridines have been conveniently synthesized from pyridine N-oxides and alkynes under visible-light-mediation in a metal-free manner. The alkynes served as both alkylating and acylating agents via switching between anaerobic and aerobic conditions. The overall strategy accommodates a broad scope of substituted pyridine N-oxides and alkynes, with excellent regioselectivity in a number of cases.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK in AMER CHEMICAL SOC published article about BETA-AMYLOID AGGREGATION; ACETYLCHOLINESTERASE INHIBITOR; ACID-DERIVATIVES; DIRECTED LIGANDS; DESIGN; PEPTIDE; ASSAY; SITE; BUTYRYLCHOLINESTERASE; NEUROTOXICITY in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India in 2019, Cited 80. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

Category: phthalazines. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. In 2019 J ORG CHEM published article about AMIDE BOND FORMATION; DIPHENYLPHOSPHORYL AZIDE; CONVENIENT REAGENT; SUBSTITUTED UREAS; AMIDATION in [Kurnar, Arun; Kumar, Naveen; Mahajan, Dinesh] Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 121001, Haryana, India; [Sharma, Ritika; Bhargava, Gaurav] IK Gujral Punjab Tech Univ, Dept Chem Sci, Kapurthala 144603, Punjab, India in 2019, Cited 50. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem